Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial

Sharana Mahomed, Carmen A Paez, Yunda Huang, Kelly E Seaton, Chenchen Yu, Kevin Gillespie, Maurine D Miner, Shelly T Karuna, Theresa Gamble, Jack Heptinstall, Elize Domin, Haili Tang, Lu Zhang, Fei Gao, Margaret Yacovone, Hans M L Spiegel, Julie Dumond, Maija A Anderson, Estelle Piwowar-Manning, Bonnie J Dye, India Tindale, Lori Proulx-Burns, Meg Trahey, Simbarashe Takuva, Azwidihwi Takalani, Veronique C Bailey, Spyros A Kalams, Hyman Scott, Josphat Kosgei, Sinéad Delany-Moretlwe, Sheetal Kassim, Fatima Laher, Z Mike Chirenje, Yeukai Musodza, Felix Mhlanga, Nonhlanhla Mkhize, Joshua A Weiner, Margaret E Ackerman, M Juliana McElrath, Michael N Pensiero, Lucio Gama, Dan H Barouch, Lawrence Corey, Myron S Cohen, David C Montefiori, Georgia D Tomaras, Marc Siegel, Colleen F Kelley, Margaret E. Ackerman, Maija A Anderson, Michael Archibald, Kathryn Axelrod, Veronique C. Bailey, Saman Baral, Dan H. Barouch, Gail Broder, Wairimu Chege, Shawn Chiambah, Kelvin Chiong, Z. Mike Chirenje, Myron S. Cohen, Lawrence Corey, Sinéad Delany-Moretlwe, Elize Domin, Jaiden Dumas, Julie Dumond, Bonnie J. Dye, Lucio Gama, Theresa Gamble, Fei Gao, Kevin Gillespie, Chelsea Greer, Jen Hanke, Nicholas Hastings, Jack Heptinstall, Nate Holm, Yunda Huang, Zoe Jones, Spyros A. Kalams, Geoffrey Kamau, Shelly T. Karuna, Sheetal Kassim, Colleen Kelley, Robert Klitzman, Josphat Kosgei, Gabriela Kovacikova, Fatima Laher, Judith Lucas, Jonathan Lucas, Sharana Mahomed, Anders McConachie, M. Juliana McElrath, Tara McNair, Felix Mhlanga, Maurine D. Miner, Nonhlanhla Mkhize, David C. Montefiori, Amber Moser, Yeukai Musodza, Carmen A. Paez, Michael N. Pensiero, Estelle Piwowar-Manning, Lori Proulx-Burns, Lynette Purdue, April Randhawa, Laurie Rinn, Sheetal Sawant, Hyman Scott, Kelly E. Seaton, Angelina Sharak, Marc Siegel, Hans M.L. Spiegel, Kenneth R. Stroop, Shonda E. Sumner, Azwidihwi Takalani, Simbarashe Takuva, Haili Tang, India Tindale, Georgia D. Tomaras, Meg Trahey, Lenka Tswenyana, Melissa Turner, Joshua A. Weiner, Haven Wilvich, Margaret Yacovone, Nicole Yates, Hannah Yellin, Ntando Yola, Chenchen Yu, Lu Zhang

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DOI: 10.1016/s2352-3018(25)00356-x
Published: 2026-07
Container: The Lancet HIV
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s2352-3018-25-00356-x,
title = {Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial},
author = {Sharana Mahomed and Carmen A Paez and Yunda Huang and Kelly E Seaton and Chenchen Yu and Kevin Gillespie and Maurine D Miner and Shelly T Karuna and Theresa Gamble and Jack Heptinstall and Elize Domin and Haili Tang and Lu Zhang and Fei Gao and Margaret Yacovone and Hans M L Spiegel and Julie Dumond and Maija A Anderson and Estelle Piwowar-Manning and Bonnie J Dye and India Tindale and Lori Proulx-Burns and Meg Trahey and Simbarashe Takuva and Azwidihwi Takalani and Veronique C Bailey and Spyros A Kalams and Hyman Scott and Josphat Kosgei and Sinéad Delany-Moretlwe and Sheetal Kassim and Fatima Laher and Z Mike Chirenje and Yeukai Musodza and Felix Mhlanga and Nonhlanhla Mkhize and Joshua A Weiner and Margaret E Ackerman and M Juliana McElrath and Michael N Pensiero and Lucio Gama and Dan H Barouch and Lawrence Corey and Myron S Cohen and David C Montefiori and Georgia D Tomaras and Marc Siegel and Colleen F Kelley and Margaret E. Ackerman and Maija A Anderson and Michael Archibald and Kathryn Axelrod and Veronique C. Bailey and Saman Baral and Dan H. Barouch and Gail Broder and Wairimu Chege and Shawn Chiambah and Kelvin Chiong and Z. Mike Chirenje and Myron S. Cohen and Lawrence Corey and Sinéad Delany-Moretlwe and Elize Domin and Jaiden Dumas and Julie Dumond and Bonnie J. Dye and Lucio Gama and Theresa Gamble and Fei Gao and Kevin Gillespie and Chelsea Greer and Jen Hanke and Nicholas Hastings and Jack Heptinstall and Nate Holm and Yunda Huang and Zoe Jones and Spyros A. Kalams and Geoffrey Kamau and Shelly T. Karuna and Sheetal Kassim and Colleen Kelley and Robert Klitzman and Josphat Kosgei and Gabriela Kovacikova and Fatima Laher and Judith Lucas and Jonathan Lucas and Sharana Mahomed and Anders McConachie and M. Juliana McElrath and Tara McNair and Felix Mhlanga and Maurine D. Miner and Nonhlanhla Mkhize and David C. Montefiori and Amber Moser and Yeukai Musodza and Carmen A. Paez and Michael N. Pensiero and Estelle Piwowar-Manning and Lori Proulx-Burns and Lynette Purdue and April Randhawa and Laurie Rinn and Sheetal Sawant and Hyman Scott and Kelly E. Seaton and Angelina Sharak and Marc Siegel and Hans M.L. Spiegel and Kenneth R. Stroop and Shonda E. Sumner and Azwidihwi Takalani and Simbarashe Takuva and Haili Tang and India Tindale and Georgia D. Tomaras and Meg Trahey and Lenka Tswenyana and Melissa Turner and Joshua A. Weiner and Haven Wilvich and Margaret Yacovone and Nicole Yates and Hannah Yellin and Ntando Yola and Chenchen Yu and Lu Zhang},
year = {2026},
journal = {The Lancet HIV},
doi = {10.1016/s2352-3018(25)00356-x},
url = {https://doi.org/10.1016/s2352-3018(25)00356-x}
}

RIS

TY  - JOUR
TI  - Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial
AU  - Sharana Mahomed
AU  - Carmen A Paez
AU  - Yunda Huang
AU  - Kelly E Seaton
AU  - Chenchen Yu
AU  - Kevin Gillespie
AU  - Maurine D Miner
AU  - Shelly T Karuna
AU  - Theresa Gamble
AU  - Jack Heptinstall
AU  - Elize Domin
AU  - Haili Tang
AU  - Lu Zhang
AU  - Fei Gao
AU  - Margaret Yacovone
AU  - Hans M L Spiegel
AU  - Julie Dumond
AU  - Maija A Anderson
AU  - Estelle Piwowar-Manning
AU  - Bonnie J Dye
AU  - India Tindale
AU  - Lori Proulx-Burns
AU  - Meg Trahey
AU  - Simbarashe Takuva
AU  - Azwidihwi Takalani
AU  - Veronique C Bailey
AU  - Spyros A Kalams
AU  - Hyman Scott
AU  - Josphat Kosgei
AU  - Sinéad Delany-Moretlwe
AU  - Sheetal Kassim
AU  - Fatima Laher
AU  - Z Mike Chirenje
AU  - Yeukai Musodza
AU  - Felix Mhlanga
AU  - Nonhlanhla Mkhize
AU  - Joshua A Weiner
AU  - Margaret E Ackerman
AU  - M Juliana McElrath
AU  - Michael N Pensiero
AU  - Lucio Gama
AU  - Dan H Barouch
AU  - Lawrence Corey
AU  - Myron S Cohen
AU  - David C Montefiori
AU  - Georgia D Tomaras
AU  - Marc Siegel
AU  - Colleen F Kelley
AU  - Margaret E. Ackerman
AU  - Maija A Anderson
AU  - Michael Archibald
AU  - Kathryn Axelrod
AU  - Veronique C. Bailey
AU  - Saman Baral
AU  - Dan H. Barouch
AU  - Gail Broder
AU  - Wairimu Chege
AU  - Shawn Chiambah
AU  - Kelvin Chiong
AU  - Z. Mike Chirenje
AU  - Myron S. Cohen
AU  - Lawrence Corey
AU  - Sinéad Delany-Moretlwe
AU  - Elize Domin
AU  - Jaiden Dumas
AU  - Julie Dumond
AU  - Bonnie J. Dye
AU  - Lucio Gama
AU  - Theresa Gamble
AU  - Fei Gao
AU  - Kevin Gillespie
AU  - Chelsea Greer
AU  - Jen Hanke
AU  - Nicholas Hastings
AU  - Jack Heptinstall
AU  - Nate Holm
AU  - Yunda Huang
AU  - Zoe Jones
AU  - Spyros A. Kalams
AU  - Geoffrey Kamau
AU  - Shelly T. Karuna
AU  - Sheetal Kassim
AU  - Colleen Kelley
AU  - Robert Klitzman
AU  - Josphat Kosgei
AU  - Gabriela Kovacikova
AU  - Fatima Laher
AU  - Judith Lucas
AU  - Jonathan Lucas
AU  - Sharana Mahomed
AU  - Anders McConachie
AU  - M. Juliana McElrath
AU  - Tara McNair
AU  - Felix Mhlanga
AU  - Maurine D. Miner
AU  - Nonhlanhla Mkhize
AU  - David C. Montefiori
AU  - Amber Moser
AU  - Yeukai Musodza
AU  - Carmen A. Paez
AU  - Michael N. Pensiero
AU  - Estelle Piwowar-Manning
AU  - Lori Proulx-Burns
AU  - Lynette Purdue
AU  - April Randhawa
AU  - Laurie Rinn
AU  - Sheetal Sawant
AU  - Hyman Scott
AU  - Kelly E. Seaton
AU  - Angelina Sharak
AU  - Marc Siegel
AU  - Hans M.L. Spiegel
AU  - Kenneth R. Stroop
AU  - Shonda E. Sumner
AU  - Azwidihwi Takalani
AU  - Simbarashe Takuva
AU  - Haili Tang
AU  - India Tindale
AU  - Georgia D. Tomaras
AU  - Meg Trahey
AU  - Lenka Tswenyana
AU  - Melissa Turner
AU  - Joshua A. Weiner
AU  - Haven Wilvich
AU  - Margaret Yacovone
AU  - Nicole Yates
AU  - Hannah Yellin
AU  - Ntando Yola
AU  - Chenchen Yu
AU  - Lu Zhang
PY  - 2026
JO  - The Lancet HIV
DO  - 10.1016/s2352-3018(25)00356-x
UR  - https://doi.org/10.1016/s2352-3018(25)00356-x
ER  -

APA

Mahomed, S., Paez, C. A., Huang, Y., Seaton, K. E., Yu, C., Gillespie, K., Miner, M. D., Karuna, S. T., Gamble, T., Heptinstall, J., Domin, E., Tang, H., Zhang, L., Gao, F., Yacovone, M., Spiegel, H. M. L., Dumond, J., Anderson, M. A., Piwowar-Manning, E., Dye, B. J., Tindale, I., Proulx-Burns, L., Trahey, M., Takuva, S., Takalani, A., Bailey, V. C., Kalams, S. A., Scott, H., Kosgei, J., Delany-Moretlwe, S., Kassim, S., Laher, F., Chirenje, Z. M., Musodza, Y., Mhlanga, F., Mkhize, N., Weiner, J. A., Ackerman, M. E., McElrath, M. J., Pensiero, M. N., Gama, L., Barouch, D. H., Corey, L., Cohen, M. S., Montefiori, D. C., Tomaras, G. D., Siegel, M., Kelley, C. F., Ackerman, M. E., Anderson, M. A., Archibald, M., Axelrod, K., Bailey, V. C., Baral, S., Barouch, D. H., Broder, G., Chege, W., Chiambah, S., Chiong, K., Chirenje, Z. M., Cohen, M. S., Corey, L., Delany-Moretlwe, S., Domin, E., Dumas, J., Dumond, J., Dye, B. J., Gama, L., Gamble, T., Gao, F., Gillespie, K., Greer, C., Hanke, J., Hastings, N., Heptinstall, J., Holm, N., Huang, Y., Jones, Z., Kalams, S. A., Kamau, G., Karuna, S. T., Kassim, S., Kelley, C., Klitzman, R., Kosgei, J., Kovacikova, G., Laher, F., Lucas, J., Lucas, J., Mahomed, S., McConachie, A., McElrath, M. J., McNair, T., Mhlanga, F., Miner, M. D., Mkhize, N., Montefiori, D. C., Moser, A., Musodza, Y., Paez, C. A., Pensiero, M. N., Piwowar-Manning, E., Proulx-Burns, L., Purdue, L., Randhawa, A., Rinn, L., Sawant, S., Scott, H., Seaton, K. E., Sharak, A., Siegel, M., Spiegel, H. M., Stroop, K. R., Sumner, S. E., Takalani, A., Takuva, S., Tang, H., Tindale, I., Tomaras, G. D., Trahey, M., Tswenyana, L., Turner, M., Weiner, J. A., Wilvich, H., Yacovone, M., Yates, N., Yellin, H., Yola, N., Yu, C., & Zhang, L. (2026). Safety, pharmacokinetics, and neutralisation activity of PGDM1400LS, VRC07-523LS, and PGT121.414.LS infused intravenously or subcutaneously (HVTN 140/HPTN 101 part B): a phase 1, randomised trial. The Lancet HIV. https://doi.org/10.1016/s2352-3018(25)00356-x

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crossref · retrieved 2026-09-26T10:39:58.540Z