Long-term outcomes of top-down therapy versus a conventional step-up strategy in adults newly diagnosed with Crohn's disease: 5-year follow-up of the PROFILE trial

Nurulamin M Noor, Mohmmed Tauseef Sharip, Haiyan Zheng, Barry Widmer, Biljana Brezina, Kamal V Patel, Francis Dowling, Suhaylah Bhatti, Nadia Alsmade, Tariq Ahmad, Paul J Banim, James W Berrill, Rachel Cooney, Juan De La Revilla Negro, Shanika de Silva, Shahida Din, Dharmaraj Durai, John N Gordon, Ailsa L Hart, Peter M Irving, Matthew Johnson, Alexandra J Kent, Klaartje B Kok, Gordon W Moran, Craig Mowat, Pritash Patel, Tim Raine, Rebecca Saich, Dan Sharpstone, Melissa A Smith, Alan Steel, Sreedhar Subramanian, Alan Wiles, Horace R T Williams, James O Lindsay, Nicholas A Kennedy, Eoin F McKinney, Paul A Lyons, Kenneth G C Smith, James C Lee, David S Robertson, Miles Parkes, Kevin Agravante, Ranya Alias, Maria Baffa-Scinelli, Samantha Baillie, Alice-Mihaela Balaican, Megha Bhandari, Zareen Bheekun, Gülden Bilican, Jonathan Blackwell, Robert Boulton-Jones, Louise Bowlas, Fran Bredin, Claire Burston, Rhys Butcher, Jeffrey Butterworth, Rakesh Chaudhary, Kelechi Chigbu Nwaneri, Lee Meng Choong, Andy Cole, Michael Colwill, Gareth Corbett, Hayley Cousins, Sheetal Crasta, Neethu Das, Katja De Paepe, Geert D'Haens, Anjan Dhar, Helen Diack, Sunita Diasjuliao, Antonio Dilena, Andrea D'Mello, Marieline El Asmar, Francesco Ferraro, Edmund Godfrey, Marie Green, Bejnamin Hamilton, Philip Harvey, Katy Hickman, Stefanie Hobson, Yu-Kai Hsu, Dipshi Jain, Vipul Jairath, Babur Javaid, Kate Jennings, Anoop John, Sonia Kalyanji-Mehta, Chan Keat Kang, Amirhosein Kefayat, Samir Khwaja, Paul Knight, Tessa Lawton, Irish Lee, Charlie Lees, Andy Li, Muhammad Liaqat, Rachel Lorusso, Jacob Lucas, Faye McMeeken, Menaga Muruganantham, Gareth Parkes, Tanvi Patel, Lahja Paulus, Shona Perry, Toni Po, Richard Pollok, Sam Powles, Arvind Ramadas, Valentina Raspa, Chris Roberts, Lindsay Rogers, Eathar Shakweh, Natalie Shields, Rohit Sundramoorthi, Helen Sutherland, Valentina Toska, Simon Travis, Sara Upponi, Aaditya Viswanath, Emma Ward, Sean Weaver, Emma Wesley, Ami Wilkinson, Angharad Williams, Imogen Winfield

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DOI: 10.1016/s2468-1253(26)00192-5
Published: 2026-11
Container: The Lancet Gastroenterology & Hepatology
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s2468-1253-26-00192-5,
  title = {Long-term outcomes of top-down therapy versus a conventional step-up strategy in adults newly diagnosed with Crohn's disease: 5-year follow-up of the PROFILE trial},
  author = {Nurulamin M Noor and Mohmmed Tauseef Sharip and Haiyan Zheng and Barry Widmer and Biljana Brezina and Kamal V Patel and Francis Dowling and Suhaylah Bhatti and Nadia Alsmade and Tariq Ahmad and Paul J Banim and James W Berrill and Rachel Cooney and Juan De La Revilla Negro and Shanika de Silva and Shahida Din and Dharmaraj Durai and John N Gordon and Ailsa L Hart and Peter M Irving and Matthew Johnson and Alexandra J Kent and Klaartje B Kok and Gordon W Moran and Craig Mowat and Pritash Patel and Tim Raine and Rebecca Saich and Dan Sharpstone and Melissa A Smith and Alan Steel and Sreedhar Subramanian and Alan Wiles and Horace R T Williams and James O Lindsay and Nicholas A Kennedy and Eoin F McKinney and Paul A Lyons and Kenneth G C Smith and James C Lee and David S Robertson and Miles Parkes and Kevin Agravante and Ranya Alias and Maria Baffa-Scinelli and Samantha Baillie and Alice-Mihaela Balaican and Megha Bhandari and Zareen Bheekun and Gülden Bilican and Jonathan Blackwell and Robert Boulton-Jones and Louise Bowlas and Fran Bredin and Claire Burston and Rhys Butcher and Jeffrey Butterworth and Rakesh Chaudhary and Kelechi Chigbu Nwaneri and Lee Meng Choong and Andy Cole and Michael Colwill and Gareth Corbett and Hayley Cousins and Sheetal Crasta and Neethu Das and Katja De Paepe and Geert D'Haens and Anjan Dhar and Helen Diack and Sunita Diasjuliao and Antonio Dilena and Andrea D'Mello and Marieline El Asmar and Francesco Ferraro and Edmund Godfrey and Marie Green and Bejnamin Hamilton and Philip Harvey and Katy Hickman and Stefanie Hobson and Yu-Kai Hsu and Dipshi Jain and Vipul Jairath and Babur Javaid and Kate Jennings and Anoop John and Sonia Kalyanji-Mehta and Chan Keat Kang and Amirhosein Kefayat and Samir Khwaja and Paul Knight and Tessa Lawton and Irish Lee and Charlie Lees and Andy Li and Muhammad Liaqat and Rachel Lorusso and Jacob Lucas and Faye McMeeken and Menaga Muruganantham and Gareth Parkes and Tanvi Patel and Lahja Paulus and Shona Perry and Toni Po and Richard Pollok and Sam Powles and Arvind Ramadas and Valentina Raspa and Chris Roberts and Lindsay Rogers and Eathar Shakweh and Natalie Shields and Rohit Sundramoorthi and Helen Sutherland and Valentina Toska and Simon Travis and Sara Upponi and Aaditya Viswanath and Emma Ward and Sean Weaver and Emma Wesley and Ami Wilkinson and Angharad Williams and Imogen Winfield},
  year = {2026},
  journal = {The Lancet Gastroenterology \&amp; Hepatology},
  doi = {10.1016/s2468-1253(26)00192-5},
  url = {https://doi.org/10.1016/s2468-1253(26)00192-5}
}

RIS

TY  - JOUR
TI  - Long-term outcomes of top-down therapy versus a conventional step-up strategy in adults newly diagnosed with Crohn's disease: 5-year follow-up of the PROFILE trial
AU  - Nurulamin M Noor
AU  - Mohmmed Tauseef Sharip
AU  - Haiyan Zheng
AU  - Barry Widmer
AU  - Biljana Brezina
AU  - Kamal V Patel
AU  - Francis Dowling
AU  - Suhaylah Bhatti
AU  - Nadia Alsmade
AU  - Tariq Ahmad
AU  - Paul J Banim
AU  - James W Berrill
AU  - Rachel Cooney
AU  - Juan De La Revilla Negro
AU  - Shanika de Silva
AU  - Shahida Din
AU  - Dharmaraj Durai
AU  - John N Gordon
AU  - Ailsa L Hart
AU  - Peter M Irving
AU  - Matthew Johnson
AU  - Alexandra J Kent
AU  - Klaartje B Kok
AU  - Gordon W Moran
AU  - Craig Mowat
AU  - Pritash Patel
AU  - Tim Raine
AU  - Rebecca Saich
AU  - Dan Sharpstone
AU  - Melissa A Smith
AU  - Alan Steel
AU  - Sreedhar Subramanian
AU  - Alan Wiles
AU  - Horace R T Williams
AU  - James O Lindsay
AU  - Nicholas A Kennedy
AU  - Eoin F McKinney
AU  - Paul A Lyons
AU  - Kenneth G C Smith
AU  - James C Lee
AU  - David S Robertson
AU  - Miles Parkes
AU  - Kevin Agravante
AU  - Ranya Alias
AU  - Maria Baffa-Scinelli
AU  - Samantha Baillie
AU  - Alice-Mihaela Balaican
AU  - Megha Bhandari
AU  - Zareen Bheekun
AU  - Gülden Bilican
AU  - Jonathan Blackwell
AU  - Robert Boulton-Jones
AU  - Louise Bowlas
AU  - Fran Bredin
AU  - Claire Burston
AU  - Rhys Butcher
AU  - Jeffrey Butterworth
AU  - Rakesh Chaudhary
AU  - Kelechi Chigbu Nwaneri
AU  - Lee Meng Choong
AU  - Andy Cole
AU  - Michael Colwill
AU  - Gareth Corbett
AU  - Hayley Cousins
AU  - Sheetal Crasta
AU  - Neethu Das
AU  - Katja De Paepe
AU  - Geert D'Haens
AU  - Anjan Dhar
AU  - Helen Diack
AU  - Sunita Diasjuliao
AU  - Antonio Dilena
AU  - Andrea D'Mello
AU  - Marieline El Asmar
AU  - Francesco Ferraro
AU  - Edmund Godfrey
AU  - Marie Green
AU  - Bejnamin Hamilton
AU  - Philip Harvey
AU  - Katy Hickman
AU  - Stefanie Hobson
AU  - Yu-Kai Hsu
AU  - Dipshi Jain
AU  - Vipul Jairath
AU  - Babur Javaid
AU  - Kate Jennings
AU  - Anoop John
AU  - Sonia Kalyanji-Mehta
AU  - Chan Keat Kang
AU  - Amirhosein Kefayat
AU  - Samir Khwaja
AU  - Paul Knight
AU  - Tessa Lawton
AU  - Irish Lee
AU  - Charlie Lees
AU  - Andy Li
AU  - Muhammad Liaqat
AU  - Rachel Lorusso
AU  - Jacob Lucas
AU  - Faye McMeeken
AU  - Menaga Muruganantham
AU  - Gareth Parkes
AU  - Tanvi Patel
AU  - Lahja Paulus
AU  - Shona Perry
AU  - Toni Po
AU  - Richard Pollok
AU  - Sam Powles
AU  - Arvind Ramadas
AU  - Valentina Raspa
AU  - Chris Roberts
AU  - Lindsay Rogers
AU  - Eathar Shakweh
AU  - Natalie Shields
AU  - Rohit Sundramoorthi
AU  - Helen Sutherland
AU  - Valentina Toska
AU  - Simon Travis
AU  - Sara Upponi
AU  - Aaditya Viswanath
AU  - Emma Ward
AU  - Sean Weaver
AU  - Emma Wesley
AU  - Ami Wilkinson
AU  - Angharad Williams
AU  - Imogen Winfield
PY  - 2026
JO  - The Lancet Gastroenterology &amp; Hepatology
DO  - 10.1016/s2468-1253(26)00192-5
UR  - https://doi.org/10.1016/s2468-1253(26)00192-5
ER  -

APA

Noor, N. M., Sharip, M. T., Zheng, H., Widmer, B., Brezina, B., Patel, K. V., Dowling, F., Bhatti, S., Alsmade, N., Ahmad, T., Banim, P. J., Berrill, J. W., Cooney, R., Negro, J. D. L. R., Silva, S. D., Din, S., Durai, D., Gordon, J. N., Hart, A. L., Irving, P. M., Johnson, M., Kent, A. J., Kok, K. B., Moran, G. W., Mowat, C., Patel, P., Raine, T., Saich, R., Sharpstone, D., Smith, M. A., Steel, A., Subramanian, S., Wiles, A., Williams, H. R. T., Lindsay, J. O., Kennedy, N. A., McKinney, E. F., Lyons, P. A., Smith, K. G. C., Lee, J. C., Robertson, D. S., Parkes, M., Agravante, K., Alias, R., Baffa-Scinelli, M., Baillie, S., Balaican, A., Bhandari, M., Bheekun, Z., Bilican, G., Blackwell, J., Boulton-Jones, R., Bowlas, L., Bredin, F., Burston, C., Butcher, R., Butterworth, J., Chaudhary, R., Nwaneri, K. C., Choong, L. M., Cole, A., Colwill, M., Corbett, G., Cousins, H., Crasta, S., Das, N., Paepe, K. D., D'Haens, G., Dhar, A., Diack, H., Diasjuliao, S., Dilena, A., D'Mello, A., Asmar, M. E., Ferraro, F., Godfrey, E., Green, M., Hamilton, B., Harvey, P., Hickman, K., Hobson, S., Hsu, Y., Jain, D., Jairath, V., Javaid, B., Jennings, K., John, A., Kalyanji-Mehta, S., Kang, C. K., Kefayat, A., Khwaja, S., Knight, P., Lawton, T., Lee, I., Lees, C., Li, A., Liaqat, M., Lorusso, R., Lucas, J., McMeeken, F., Muruganantham, M., Parkes, G., Patel, T., Paulus, L., Perry, S., Po, T., Pollok, R., Powles, S., Ramadas, A., Raspa, V., Roberts, C., Rogers, L., Shakweh, E., Shields, N., Sundramoorthi, R., Sutherland, H., Toska, V., Travis, S., Upponi, S., Viswanath, A., Ward, E., Weaver, S., Wesley, E., Wilkinson, A., Williams, A., & Winfield, I. (2026). Long-term outcomes of top-down therapy versus a conventional step-up strategy in adults newly diagnosed with Crohn's disease: 5-year follow-up of the PROFILE trial. The Lancet Gastroenterology & Hepatology. https://doi.org/10.1016/s2468-1253(26)00192-5

Source records

crossref · retrieved 2026-11-10T20:58:56.450Z