Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study

Lukas Otero Sanchez, Joan Clària, Clélia Galvanin, Ferran Aguilar, Richard Layese, Matteo Serra, Laura Jiménez-Gracia, Paula Nieto, Darko Castven, Sona Frankova, Milan Jirsa, David Tornai, Anna Curto-Vilalta, Alberto Queiroz Farias, Maria Papp, Patricia Momoyo Zitelli, Paolo Caraceni, Giacomo Zaccherini, Luciana L Goncalves, Carlo Alessandria, Gustavo Pereira, Wim Laleman, Adrian C Gadano, Salvatore Piano, Angelo Z Mattos, Desislava Germanova, Valério Lucidi, Daphnée Soret, Line Carolle Ntandja Wandji, Frank Erhard Uschner, Aldo Torre, Victor Vargas, Liliana S C Mendes, Rajeshwar P Mookerjee, Carlos Benitez, Mario R Alvares-da-Silva, Myriam Remmelink, Paulo L Bittencourt, Agustin Albillos, Claudia Alves Couto, Rafael Bañares, Manuel Mendizabal, Delphine Degré, Claudio L Toledo, Martin Janicko, Daniel F Mazo, Mauricio Castillo Barradas, William Bernal, Adelina Zarela Lozano Miranda, P Martín Padilla-Machaca, Alexander Zipprich, René Malé-Velázquez, Christophe Moreno, André Castro Lyra, Flair Carrilho, Javier Fernandez, Jonel Trebicka, Rajiv Jalan, Paolo Angeli, Horia Stefanescu, Pierre-Emmanuel Rautou, Stephan Buch, Alexandre Louvet, Jens U Marquardt, Thierry Gustot, Holger Heyn, Juan C Nieto, Vicente Arroyo, Nathalie Ganne-Carrié, Jan Sperl, Richard Moreau, Philippe Mathurin, Pierre Nahon, Eric Trépo, Caroline Marcondes, José M. Aquino Ramos, María de Fátima Higuera de la Tijera, Francisca Allendes, Izabelle Venturini Signorelli, Caroline A. Pinto, Angelo A. Mattos, Fernando C. Schacher, Guilherme John Neto, Lilian Montserrat Torres-Made, Raúl Castro Valdivia, Diana C. Salinas-Gómez, M. Ligia Aparecida, José Presa Ramos, Everton Macêdo, Josefina Pagés, Roberto M. Fernandes da Costa, Jorge Garavito Reiteria, Eduardo Garcia Vilela, Laura C. Tenorio Castillo, Augusto Mantovani, Larisse Longo, Juan P. Roblero, Rodrigo S. Aires, Hugo Fainboim, Michelle V.S. Santos-Rondon, Fernanda Fernandes Souza, María N. Gutierrez-Acevedo, Agustina M. Martinez-Garmendia, Luis Colombato, Renata de Mello Peres, Larissa O. Miranda, Jade C. Oliveira, Leyla Nazal Ortiz, Daniela Simian, Gabriel Mezzano Puentes, Maria G. Valderrama, Rita de Cássia Martins Alves da Silva, Alma Estanes-Hernández, Jesús Ruiz Manriquez, Iaarah Montalvo Gordon, Luis A. Chi Cervera, Marcos A. Girala Salomón, María T. Cuevas, Pedro Montes, Maximo J. Cattaneo Buteler, Bertha Cardenas, Debora R. Benedita Terrabuio, Juan M. Diaz, Eva Uson Raposo, Milagros B. Dávalos-Moscol, Jose L. Pérez Hernandez, Rafael O. Ximenes, Giovanni Faria Silva, Oscar A. Beltrán-Galvis, María S. González Huezo, Fernando Bessone, Tarciso D.S. Rocha, Eduardo Fassio, Carlos Terra, Juan I. Marín, Patricia Sierra Casas, Carlos De La Peña-Ramírez, Flavia Fernandes, Maria da Penha Zago-Gomes, Osvely Méndez-Guerrero, Sebastián Marciano, Joao C. Oliveira, Gabriel T.S. Guerreiro, Liana Codes, Marco Arrese, Mateus Jorge Nardelli, Marcelo O. Silva, Renato Palma-Fernandez, Camila Alcantara, Cristina Sánchez-Garrido

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DOI
10.1016/s2468-1253(26)00217-7
Published
2026-12
Container
The Lancet Gastroenterology & Hepatology
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/s2468-1253-26-00217-7,
  title = {Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study},
  author = {Lukas Otero Sanchez and Joan Clària and Clélia Galvanin and Ferran Aguilar and Richard Layese and Matteo Serra and Laura Jiménez-Gracia and Paula Nieto and Darko Castven and Sona Frankova and Milan Jirsa and David Tornai and Anna Curto-Vilalta and Alberto Queiroz Farias and Maria Papp and Patricia Momoyo Zitelli and Paolo Caraceni and Giacomo Zaccherini and Luciana L Goncalves and Carlo Alessandria and Gustavo Pereira and Wim Laleman and Adrian C Gadano and Salvatore Piano and Angelo Z Mattos and Desislava Germanova and Valério Lucidi and Daphnée Soret and Line Carolle Ntandja Wandji and Frank Erhard Uschner and Aldo Torre and Victor Vargas and Liliana S C Mendes and Rajeshwar P Mookerjee and Carlos Benitez and Mario R Alvares-da-Silva and Myriam Remmelink and Paulo L Bittencourt and Agustin Albillos and Claudia Alves Couto and Rafael Bañares and Manuel Mendizabal and Delphine Degré and Claudio L Toledo and Martin Janicko and Daniel F Mazo and Mauricio Castillo Barradas and William Bernal and Adelina Zarela Lozano Miranda and P Martín Padilla-Machaca and Alexander Zipprich and René Malé-Velázquez and Christophe Moreno and André Castro Lyra and Flair Carrilho and Javier Fernandez and Jonel Trebicka and Rajiv Jalan and Paolo Angeli and Horia Stefanescu and Pierre-Emmanuel Rautou and Stephan Buch and Alexandre Louvet and Jens U Marquardt and Thierry Gustot and Holger Heyn and Juan C Nieto and Vicente Arroyo and Nathalie Ganne-Carrié and Jan Sperl and Richard Moreau and Philippe Mathurin and Pierre Nahon and Eric Trépo and Caroline Marcondes and José M. Aquino Ramos and María de Fátima Higuera de la Tijera and Francisca Allendes and Izabelle Venturini Signorelli and Caroline A. Pinto and Angelo A. Mattos and Fernando C. Schacher and Guilherme John Neto and Lilian Montserrat Torres-Made and Raúl Castro Valdivia and Diana C. Salinas-Gómez and M. Ligia Aparecida and José Presa Ramos and Everton Macêdo and Josefina Pagés and Roberto M. Fernandes da Costa and Jorge Garavito Reiteria and Eduardo Garcia Vilela and Laura C. Tenorio Castillo and Augusto Mantovani and Larisse Longo and Juan P. Roblero and Rodrigo S. Aires and Hugo Fainboim and Michelle V.S. Santos-Rondon and Fernanda Fernandes Souza and María N. Gutierrez-Acevedo and Agustina M. Martinez-Garmendia and Luis Colombato and Renata de Mello Peres and Larissa O. Miranda and Jade C. Oliveira and Leyla Nazal Ortiz and Daniela Simian and Gabriel Mezzano Puentes and Maria G. Valderrama and Rita de Cássia Martins Alves da Silva and Alma Estanes-Hernández and Jesús Ruiz Manriquez and Iaarah Montalvo Gordon and Luis A. Chi Cervera and Marcos A. Girala Salomón and María T. Cuevas and Pedro Montes and Maximo J. Cattaneo Buteler and Bertha Cardenas and Debora R. Benedita Terrabuio and Juan M. Diaz and Eva Uson Raposo and Milagros B. Dávalos-Moscol and Jose L. Pérez Hernandez and Rafael O. Ximenes and Giovanni Faria Silva and Oscar A. Beltrán-Galvis and María S. González Huezo and Fernando Bessone and Tarciso D.S. Rocha and Eduardo Fassio and Carlos Terra and Juan I. Marín and Patricia Sierra Casas and Carlos De La Peña-Ramírez and Flavia Fernandes and Maria da Penha Zago-Gomes and Osvely Méndez-Guerrero and Sebastián Marciano and Joao C. Oliveira and Gabriel T.S. Guerreiro and Liana Codes and Marco Arrese and Mateus Jorge Nardelli and Marcelo O. Silva and Renato Palma-Fernandez and Camila Alcantara and Cristina Sánchez-Garrido},
  year = {2026},
  journal = {The Lancet Gastroenterology \& Hepatology},
  doi = {10.1016/s2468-1253(26)00217-7},
  url = {https://doi.org/10.1016/s2468-1253(26)00217-7}
}

RIS

TY  - JOUR
TI  - Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study
AU  - Lukas Otero Sanchez
AU  - Joan Clària
AU  - Clélia Galvanin
AU  - Ferran Aguilar
AU  - Richard Layese
AU  - Matteo Serra
AU  - Laura Jiménez-Gracia
AU  - Paula Nieto
AU  - Darko Castven
AU  - Sona Frankova
AU  - Milan Jirsa
AU  - David Tornai
AU  - Anna Curto-Vilalta
AU  - Alberto Queiroz Farias
AU  - Maria Papp
AU  - Patricia Momoyo Zitelli
AU  - Paolo Caraceni
AU  - Giacomo Zaccherini
AU  - Luciana L Goncalves
AU  - Carlo Alessandria
AU  - Gustavo Pereira
AU  - Wim Laleman
AU  - Adrian C Gadano
AU  - Salvatore Piano
AU  - Angelo Z Mattos
AU  - Desislava Germanova
AU  - Valério Lucidi
AU  - Daphnée Soret
AU  - Line Carolle Ntandja Wandji
AU  - Frank Erhard Uschner
AU  - Aldo Torre
AU  - Victor Vargas
AU  - Liliana S C Mendes
AU  - Rajeshwar P Mookerjee
AU  - Carlos Benitez
AU  - Mario R Alvares-da-Silva
AU  - Myriam Remmelink
AU  - Paulo L Bittencourt
AU  - Agustin Albillos
AU  - Claudia Alves Couto
AU  - Rafael Bañares
AU  - Manuel Mendizabal
AU  - Delphine Degré
AU  - Claudio L Toledo
AU  - Martin Janicko
AU  - Daniel F Mazo
AU  - Mauricio Castillo Barradas
AU  - William Bernal
AU  - Adelina Zarela Lozano Miranda
AU  - P Martín Padilla-Machaca
AU  - Alexander Zipprich
AU  - René Malé-Velázquez
AU  - Christophe Moreno
AU  - André Castro Lyra
AU  - Flair Carrilho
AU  - Javier Fernandez
AU  - Jonel Trebicka
AU  - Rajiv Jalan
AU  - Paolo Angeli
AU  - Horia Stefanescu
AU  - Pierre-Emmanuel Rautou
AU  - Stephan Buch
AU  - Alexandre Louvet
AU  - Jens U Marquardt
AU  - Thierry Gustot
AU  - Holger Heyn
AU  - Juan C Nieto
AU  - Vicente Arroyo
AU  - Nathalie Ganne-Carrié
AU  - Jan Sperl
AU  - Richard Moreau
AU  - Philippe Mathurin
AU  - Pierre Nahon
AU  - Eric Trépo
AU  - Caroline Marcondes
AU  - José M. Aquino Ramos
AU  - María de Fátima Higuera de la Tijera
AU  - Francisca Allendes
AU  - Izabelle Venturini Signorelli
AU  - Caroline A. Pinto
AU  - Angelo A. Mattos
AU  - Fernando C. Schacher
AU  - Guilherme John Neto
AU  - Lilian Montserrat Torres-Made
AU  - Raúl Castro Valdivia
AU  - Diana C. Salinas-Gómez
AU  - M. Ligia Aparecida
AU  - José Presa Ramos
AU  - Everton Macêdo
AU  - Josefina Pagés
AU  - Roberto M. Fernandes da Costa
AU  - Jorge Garavito Reiteria
AU  - Eduardo Garcia Vilela
AU  - Laura C. Tenorio Castillo
AU  - Augusto Mantovani
AU  - Larisse Longo
AU  - Juan P. Roblero
AU  - Rodrigo S. Aires
AU  - Hugo Fainboim
AU  - Michelle V.S. Santos-Rondon
AU  - Fernanda Fernandes Souza
AU  - María N. Gutierrez-Acevedo
AU  - Agustina M. Martinez-Garmendia
AU  - Luis Colombato
AU  - Renata de Mello Peres
AU  - Larissa O. Miranda
AU  - Jade C. Oliveira
AU  - Leyla Nazal Ortiz
AU  - Daniela Simian
AU  - Gabriel Mezzano Puentes
AU  - Maria G. Valderrama
AU  - Rita de Cássia Martins Alves da Silva
AU  - Alma Estanes-Hernández
AU  - Jesús Ruiz Manriquez
AU  - Iaarah Montalvo Gordon
AU  - Luis A. Chi Cervera
AU  - Marcos A. Girala Salomón
AU  - María T. Cuevas
AU  - Pedro Montes
AU  - Maximo J. Cattaneo Buteler
AU  - Bertha Cardenas
AU  - Debora R. Benedita Terrabuio
AU  - Juan M. Diaz
AU  - Eva Uson Raposo
AU  - Milagros B. Dávalos-Moscol
AU  - Jose L. Pérez Hernandez
AU  - Rafael O. Ximenes
AU  - Giovanni Faria Silva
AU  - Oscar A. Beltrán-Galvis
AU  - María S. González Huezo
AU  - Fernando Bessone
AU  - Tarciso D.S. Rocha
AU  - Eduardo Fassio
AU  - Carlos Terra
AU  - Juan I. Marín
AU  - Patricia Sierra Casas
AU  - Carlos De La Peña-Ramírez
AU  - Flavia Fernandes
AU  - Maria da Penha Zago-Gomes
AU  - Osvely Méndez-Guerrero
AU  - Sebastián Marciano
AU  - Joao C. Oliveira
AU  - Gabriel T.S. Guerreiro
AU  - Liana Codes
AU  - Marco Arrese
AU  - Mateus Jorge Nardelli
AU  - Marcelo O. Silva
AU  - Renato Palma-Fernandez
AU  - Camila Alcantara
AU  - Cristina Sánchez-Garrido
PY  - 2026
JO  - The Lancet Gastroenterology & Hepatology
DO  - 10.1016/s2468-1253(26)00217-7
UR  - https://doi.org/10.1016/s2468-1253(26)00217-7
ER  -

APA

Sanchez, L. O., Clària, J., Galvanin, C., Aguilar, F., Layese, R., Serra, M., Jiménez-Gracia, L., Nieto, P., Castven, D., Frankova, S., Jirsa, M., Tornai, D., Curto-Vilalta, A., Farias, A. Q., Papp, M., Zitelli, P. M., Caraceni, P., Zaccherini, G., Goncalves, L. L., Alessandria, C., Pereira, G., Laleman, W., Gadano, A. C., Piano, S., Mattos, A. Z., Germanova, D., Lucidi, V., Soret, D., Wandji, L. C. N., Uschner, F. E., Torre, A., Vargas, V., Mendes, L. S. C., Mookerjee, R. P., Benitez, C., Alvares-da-Silva, M. R., Remmelink, M., Bittencourt, P. L., Albillos, A., Couto, C. A., Bañares, R., Mendizabal, M., Degré, D., Toledo, C. L., Janicko, M., Mazo, D. F., Barradas, M. C., Bernal, W., Miranda, A. Z. L., Padilla-Machaca, P. M., Zipprich, A., Malé-Velázquez, R., Moreno, C., Lyra, A. C., Carrilho, F., Fernandez, J., Trebicka, J., Jalan, R., Angeli, P., Stefanescu, H., Rautou, P., Buch, S., Louvet, A., Marquardt, J. U., Gustot, T., Heyn, H., Nieto, J. C., Arroyo, V., Ganne-Carrié, N., Sperl, J., Moreau, R., Mathurin, P., Nahon, P., Trépo, E., Marcondes, C., Ramos, J. M. A., Tijera, M. D. F. H. D. L., Allendes, F., Signorelli, I. V., Pinto, C. A., Mattos, A. A., Schacher, F. C., Neto, G. J., Torres-Made, L. M., Valdivia, R. C., Salinas-Gómez, D. C., Aparecida, M. L., Ramos, J. P., Macêdo, E., Pagés, J., Costa, R. M. F. D., Reiteria, J. G., Vilela, E. G., Castillo, L. C. T., Mantovani, A., Longo, L., Roblero, J. P., Aires, R. S., Fainboim, H., Santos-Rondon, M. V., Souza, F. F., Gutierrez-Acevedo, M. N., Martinez-Garmendia, A. M., Colombato, L., Peres, R. D. M., Miranda, L. O., Oliveira, J. C., Ortiz, L. N., Simian, D., Puentes, G. M., Valderrama, M. G., Silva, R. D. C. M. A. D., Estanes-Hernández, A., Manriquez, J. R., Gordon, I. M., Cervera, L. A. C., Salomón, M. A. G., Cuevas, M. T., Montes, P., Buteler, M. J. C., Cardenas, B., Terrabuio, D. R. B., Diaz, J. M., Raposo, E. U., Dávalos-Moscol, M. B., Hernandez, J. L. P., Ximenes, R. O., Silva, G. F., Beltrán-Galvis, O. A., Huezo, M. S. G., Bessone, F., Rocha, T. D., Fassio, E., Terra, C., Marín, J. I., Casas, P. S., Peña-Ramírez, C. D. L., Fernandes, F., Zago-Gomes, M. D. P., Méndez-Guerrero, O., Marciano, S., Oliveira, J. C., Guerreiro, G. T., Codes, L., Arrese, M., Nardelli, M. J., Silva, M. O., Palma-Fernandez, R., Alcantara, C., & Sánchez-Garrido, C. (2026). Genetic variants and the risk of renal impairment in decompensated cirrhosis: a multi-ancestry genome-wide association study. The Lancet Gastroenterology & Hepatology. https://doi.org/10.1016/s2468-1253(26)00217-7

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