Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Ina Pöhner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-da-Silva, Maria P. Costi, Alberto Venturelli, Rebecca C. Wade

Open source

DOI: 10.1021/acs.jmedchem.2c00232
Published: 2022-06-08
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.2c00232,
  title = {Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1},
  author = {Ina Pöhner and Antonio Quotadamo and Joanna Panecka-Hofman and Rosaria Luciani and Matteo Santucci and Pasquale Linciano and Giacomo Landi and Flavio Di Pisa and Lucia Dello Iacono and Cecilia Pozzi and Stefano Mangani and Sheraz Gul and Gesa Witt and Bernhard Ellinger and Maria Kuzikov and Nuno Santarem and Anabela Cordeiro-da-Silva and Maria P. Costi and Alberto Venturelli and Rebecca C. Wade},
  year = {2022},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.2c00232},
  url = {https://doi.org/10.1021/acs.jmedchem.2c00232}
}

RIS

TY  - JOUR
TI  - Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1
AU  - Ina Pöhner
AU  - Antonio Quotadamo
AU  - Joanna Panecka-Hofman
AU  - Rosaria Luciani
AU  - Matteo Santucci
AU  - Pasquale Linciano
AU  - Giacomo Landi
AU  - Flavio Di Pisa
AU  - Lucia Dello Iacono
AU  - Cecilia Pozzi
AU  - Stefano Mangani
AU  - Sheraz Gul
AU  - Gesa Witt
AU  - Bernhard Ellinger
AU  - Maria Kuzikov
AU  - Nuno Santarem
AU  - Anabela Cordeiro-da-Silva
AU  - Maria P. Costi
AU  - Alberto Venturelli
AU  - Rebecca C. Wade
PY  - 2022
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.2c00232
UR  - https://doi.org/10.1021/acs.jmedchem.2c00232
ER  -

APA

Pöhner, I., Quotadamo, A., Panecka-Hofman, J., Luciani, R., Santucci, M., Linciano, P., Landi, G., Pisa, F. D., Iacono, L. D., Pozzi, C., Mangani, S., Gul, S., Witt, G., Ellinger, B., Kuzikov, M., Santarem, N., Cordeiro-da-Silva, A., Costi, M. P., Venturelli, A., & Wade, R. C. (2022). Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.2c00232

Source records

crossref · retrieved 2026-09-26T19:20:02.264Z