Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli

Fabian Hulpia, Wim Schepens, Susan Lepri, Johan Nicolaï, Zhengyu Jiang, Sylvia F. Boj, Tammy L. Bush, Mary-ambre Carvalho, Falian Chen, Gerald Chu, Kathleen W. Clancy, Zienab Etwebi, Melissa Everaerts, Yi Fan, Froylan Omar Fernandez Candelaria, Albi Francis, Mark S. Hixon, Ferran Jardi, Shuai Jin, Egor M. Larin, Stefaan Last, Joseph E. Leenaerts, Siyu Li, Alexandra G. Liddane, Ferdinand H. Lutter, Dan Lv, Bethany Mattson, Cynthia M. Milligan, Aaron N. Patrick, Gauri Anand Patwardhan, Laura Perez-Benito, Serge Pieters, Evelien Renders, Ed Retzbach, Constance Smith-Monroy, José Silva, Mariana Silva, Hans Sterckx, Gerben ten Hag, Claudia Thäte, Sven Van Brandt, Carla S. Verissimo, Guido Verniest, Eileen Vesely, Irene Vetrano, Petra Vinken, Yufei Wang, Victoria Wong, Xuemei Yao, Jie Yang, Remco Zijlmans, Kurtis E. Bachman, David Pocalyko, Juan-Miguel Jimenez, Dana Gaffney, Jan Willem Thuring

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DOI: 10.1021/acs.jmedchem.5c00830
Published: 2025-08-26
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c00830,
  title = {Discovery of
Gut-Restricted
PRMT5 Inhibitors to Intercept
Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor
Adenomatous Polyposis Coli},
  author = {Fabian Hulpia and Wim Schepens and Susan Lepri and Johan Nicolaï and Zhengyu Jiang and Sylvia F. Boj and Tammy L. Bush and Mary-ambre Carvalho and Falian Chen and Gerald Chu and Kathleen W. Clancy and Zienab Etwebi and Melissa Everaerts and Yi Fan and Froylan Omar Fernandez Candelaria and Albi Francis and Mark S. Hixon and Ferran Jardi and Shuai Jin and Egor M. Larin and Stefaan Last and Joseph E. Leenaerts and Siyu Li and Alexandra G. Liddane and Ferdinand H. Lutter and Dan Lv and Bethany Mattson and Cynthia M. Milligan and Aaron N. Patrick and Gauri Anand Patwardhan and Laura Perez-Benito and Serge Pieters and Evelien Renders and Ed Retzbach and Constance Smith-Monroy and José Silva and Mariana Silva and Hans Sterckx and Gerben ten Hag and Claudia Thäte and Sven Van Brandt and Carla S. Verissimo and Guido Verniest and Eileen Vesely and Irene Vetrano and Petra Vinken and Yufei Wang and Victoria Wong and Xuemei Yao and Jie Yang and Remco Zijlmans and Kurtis E. Bachman and David Pocalyko and Juan-Miguel Jimenez and Dana Gaffney and Jan Willem Thuring},
  year = {2025},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.5c00830},
  url = {https://doi.org/10.1021/acs.jmedchem.5c00830}
}

RIS

TY  - JOUR
TI  - Discovery of
Gut-Restricted
PRMT5 Inhibitors to Intercept
Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor
Adenomatous Polyposis Coli
AU  - Fabian Hulpia
AU  - Wim Schepens
AU  - Susan Lepri
AU  - Johan Nicolaï
AU  - Zhengyu Jiang
AU  - Sylvia F. Boj
AU  - Tammy L. Bush
AU  - Mary-ambre Carvalho
AU  - Falian Chen
AU  - Gerald Chu
AU  - Kathleen W. Clancy
AU  - Zienab Etwebi
AU  - Melissa Everaerts
AU  - Yi Fan
AU  - Froylan Omar Fernandez Candelaria
AU  - Albi Francis
AU  - Mark S. Hixon
AU  - Ferran Jardi
AU  - Shuai Jin
AU  - Egor M. Larin
AU  - Stefaan Last
AU  - Joseph E. Leenaerts
AU  - Siyu Li
AU  - Alexandra G. Liddane
AU  - Ferdinand H. Lutter
AU  - Dan Lv
AU  - Bethany Mattson
AU  - Cynthia M. Milligan
AU  - Aaron N. Patrick
AU  - Gauri Anand Patwardhan
AU  - Laura Perez-Benito
AU  - Serge Pieters
AU  - Evelien Renders
AU  - Ed Retzbach
AU  - Constance Smith-Monroy
AU  - José Silva
AU  - Mariana Silva
AU  - Hans Sterckx
AU  - Gerben ten Hag
AU  - Claudia Thäte
AU  - Sven Van Brandt
AU  - Carla S. Verissimo
AU  - Guido Verniest
AU  - Eileen Vesely
AU  - Irene Vetrano
AU  - Petra Vinken
AU  - Yufei Wang
AU  - Victoria Wong
AU  - Xuemei Yao
AU  - Jie Yang
AU  - Remco Zijlmans
AU  - Kurtis E. Bachman
AU  - David Pocalyko
AU  - Juan-Miguel Jimenez
AU  - Dana Gaffney
AU  - Jan Willem Thuring
PY  - 2025
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.5c00830
UR  - https://doi.org/10.1021/acs.jmedchem.5c00830
ER  -

APA

Hulpia, F., Schepens, W., Lepri, S., Nicolaï, J., Jiang, Z., Boj, S. F., Bush, T. L., Carvalho, M., Chen, F., Chu, G., Clancy, K. W., Etwebi, Z., Everaerts, M., Fan, Y., Candelaria, F. O. F., Francis, A., Hixon, M. S., Jardi, F., Jin, S., Larin, E. M., Last, S., Leenaerts, J. E., Li, S., Liddane, A. G., Lutter, F. H., Lv, D., Mattson, B., Milligan, C. M., Patrick, A. N., Patwardhan, G. A., Perez-Benito, L., Pieters, S., Renders, E., Retzbach, E., Smith-Monroy, C., Silva, J., Silva, M., Sterckx, H., Hag, G. T., Thäte, C., Brandt, S. V., Verissimo, C. S., Verniest, G., Vesely, E., Vetrano, I., Vinken, P., Wang, Y., Wong, V., Yao, X., Yang, J., Zijlmans, R., Bachman, K. E., Pocalyko, D., Jimenez, J., Gaffney, D., & Thuring, J. W. (2025). Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.5c00830

Source records

crossref · retrieved 2026-09-26T23:16:32.891Z