Identification of Compound 15 (MMV1581361) as a PfATP4 Inhibitor with Transmission-Blocking Activity and In Vivo Efficacy in a SCID Mouse Model of Malaria.

Onyame HA, Brand S, Baud D, Basarab GS, Hawryluk N, Canan S, Togoh MD, Abdulai R, Eduku R, Awal M, Owoare RB, Chatterjee B, Singha Roy D, Mahapatra AKR, Bhowmik S, Putatunda P, Crespo B, Sanz L, Calvo D, Wittlin S, Tumwebaze PK, Borrows J, Amewu RK.

Open source

DOI: 10.1021/acs.jmedchem.5c01954
Published: 2026-02-11
Container: J Med Chem
Publisher: Not recorded
Open access: no

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c01954,
  title = {Identification of Compound \&lt;b\&gt;15\&lt;/b\&gt; (MMV1581361) as a \&lt;i\&gt;Pf\&lt;/i\&gt;ATP4 Inhibitor with Transmission-Blocking Activity and \&lt;i\&gt;In Vivo\&lt;/i\&gt; Efficacy in a SCID Mouse Model of Malaria.},
  author = {Onyame HA and  Brand S and  Baud D and  Basarab GS and  Hawryluk N and  Canan S and  Togoh MD and  Abdulai R and  Eduku R and  Awal M and  Owoare RB and  Chatterjee B and  Singha Roy D and  Mahapatra AKR and  Bhowmik S and  Putatunda P and  Crespo B and  Sanz L and  Calvo D and  Wittlin S and  Tumwebaze PK and  Borrows J and  Amewu RK.},
  year = {2026},
  journal = {J Med Chem},
  doi = {10.1021/acs.jmedchem.5c01954},
  url = {https://doi.org/10.1021/acs.jmedchem.5c01954}
}

RIS

TY  - JOUR
TI  - Identification of Compound &lt;b&gt;15&lt;/b&gt; (MMV1581361) as a &lt;i&gt;Pf&lt;/i&gt;ATP4 Inhibitor with Transmission-Blocking Activity and &lt;i&gt;In Vivo&lt;/i&gt; Efficacy in a SCID Mouse Model of Malaria.
AU  - Onyame HA
AU  -  Brand S
AU  -  Baud D
AU  -  Basarab GS
AU  -  Hawryluk N
AU  -  Canan S
AU  -  Togoh MD
AU  -  Abdulai R
AU  -  Eduku R
AU  -  Awal M
AU  -  Owoare RB
AU  -  Chatterjee B
AU  -  Singha Roy D
AU  -  Mahapatra AKR
AU  -  Bhowmik S
AU  -  Putatunda P
AU  -  Crespo B
AU  -  Sanz L
AU  -  Calvo D
AU  -  Wittlin S
AU  -  Tumwebaze PK
AU  -  Borrows J
AU  -  Amewu RK.
PY  - 2026
JO  - J Med Chem
DO  - 10.1021/acs.jmedchem.5c01954
UR  - https://doi.org/10.1021/acs.jmedchem.5c01954
ER  -

APA

HA, O., S, B., D, B., GS, B., N, H., S, C., MD, T., R, A., R, E., M, A., RB, O., B, C., D, S. R., AKR, M., S, B., P, P., B, C., L, S., D, C., S, W., PK, T., J, B., & RK., A. (2026). Identification of Compound 15 (MMV1581361) as a PfATP4 Inhibitor with Transmission-Blocking Activity and In Vivo Efficacy in a SCID Mouse Model of Malaria.. J Med Chem. https://doi.org/10.1021/acs.jmedchem.5c01954

Source records

europe-pmc · retrieved 2026-09-27T07:34:40.559Z

Identification of Compound &lt;b&gt;15&lt;/b&gt; (MMV1581361) as a &lt;i&gt;Pf&lt;/i&gt;ATP4 Inhibitor with Transmission-Blocking Activity and &lt;i&gt;In Vivo&lt;/i&gt; Efficacy in a SCID Mouse Model of Malaria.

Credibility signals

Cite this work

BibTeX

RIS

APA

Source records

Identification of Compound <b>15</b> (MMV1581361) as a <i>Pf</i>ATP4 Inhibitor with Transmission-Blocking Activity and <i>In Vivo</i> Efficacy in a SCID Mouse Model of Malaria.