Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Endres NF, Do S, Mroue R, Terrett JA, Saabye M, Oh A, Hunsaker T, Chan E, Tran JC, Nguyen LK, Lian Q, Ma TP, Garner T, Gerosa L, Beresini M, Boudreau A, Bronner SM, Cyr P, Ishisoko N, Izrayelit Y, Jiang F, Kellar T, La H, Labadie S, Lardy M, Liu L, Liu W, Miller S, Rudolph J, Plise E, Sellers BD, Shao C, Wang W, Wang Y, Wei W, Wong S, Yu C, Yu K, Yuen PW, Zang R, Zhang C, Zhou Y, Zhu X, Quinn JG, Ye X, Kiefer JR, Mao J, Evangelista M, Merchant M, Landry ML, Malhotra S, Purkey HE

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DOI: 10.1021/acs.jmedchem.5c02272
Published: 2026 Mar 12
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c02272,
  title = {Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.},
  author = {Endres NF and Do S and Mroue R and Terrett JA and Saabye M and Oh A and Hunsaker T and Chan E and Tran JC and Nguyen LK and Lian Q and Ma TP and Garner T and Gerosa L and Beresini M and Boudreau A and Bronner SM and Cyr P and Ishisoko N and Izrayelit Y and Jiang F and Kellar T and La H and Labadie S and Lardy M and Liu L and Liu W and Miller S and Rudolph J and Plise E and Sellers BD and Shao C and Wang W and Wang Y and Wei W and Wong S and Yu C and Yu K and Yuen PW and Zang R and Zhang C and Zhou Y and Zhu X and Quinn JG and Ye X and Kiefer JR and Mao J and Evangelista M and Merchant M and Landry ML and Malhotra S and Purkey HE},
  year = {2026},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.5c02272},
  url = {https://doi.org/10.1021/acs.jmedchem.5c02272}
}

RIS

TY  - JOUR
TI  - Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.
AU  - Endres NF
AU  - Do S
AU  - Mroue R
AU  - Terrett JA
AU  - Saabye M
AU  - Oh A
AU  - Hunsaker T
AU  - Chan E
AU  - Tran JC
AU  - Nguyen LK
AU  - Lian Q
AU  - Ma TP
AU  - Garner T
AU  - Gerosa L
AU  - Beresini M
AU  - Boudreau A
AU  - Bronner SM
AU  - Cyr P
AU  - Ishisoko N
AU  - Izrayelit Y
AU  - Jiang F
AU  - Kellar T
AU  - La H
AU  - Labadie S
AU  - Lardy M
AU  - Liu L
AU  - Liu W
AU  - Miller S
AU  - Rudolph J
AU  - Plise E
AU  - Sellers BD
AU  - Shao C
AU  - Wang W
AU  - Wang Y
AU  - Wei W
AU  - Wong S
AU  - Yu C
AU  - Yu K
AU  - Yuen PW
AU  - Zang R
AU  - Zhang C
AU  - Zhou Y
AU  - Zhu X
AU  - Quinn JG
AU  - Ye X
AU  - Kiefer JR
AU  - Mao J
AU  - Evangelista M
AU  - Merchant M
AU  - Landry ML
AU  - Malhotra S
AU  - Purkey HE
PY  - 2026
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.5c02272
UR  - https://doi.org/10.1021/acs.jmedchem.5c02272
ER  -

APA

NF, E., S, D., R, M., JA, T., M, S., A, O., T, H., E, C., JC, T., LK, N., Q, L., TP, M., T, G., L, G., M, B., A, B., SM, B., P, C., N, I., Y, I., F, J., T, K., H, L., S, L., M, L., L, L., W, L., S, M., J, R., E, P., BD, S., C, S., W, W., Y, W., W, W., S, W., C, Y., K, Y., PW, Y., R, Z., C, Z., Y, Z., X, Z., JG, Q., X, Y., JR, K., J, M., M, E., M, M., ML, L., S, M., & HE, P. (2026). Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.5c02272

Source records

pubmed · retrieved 2026-09-27T07:09:26.058Z