Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma.

Mortensen DS, Shunatona HP, Holmberg-Douglas N, Rhodes J, Da Silva D, Gamez J, Groza M, Zhu J, Christoforou A, Johnson SA, Khambatta G, Narla RK, Nimje RY, Huang D, Dodd DS, Griffin J, Miseo G, Whitefield B, Weiss DR, Rader J, Kuzu E, Leisten J, Lai C, Shi L, Del Rosario J, Dalvie D, Rolfe M, Zapf CW, Belmont P, Alexander M, Bence N, Groocock L

Open source

DOI: 10.1021/acs.jmedchem.5c03123
Published: 2026 Feb 26
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c03123,
  title = {Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma.},
  author = {Mortensen DS and Shunatona HP and Holmberg-Douglas N and Rhodes J and Da Silva D and Gamez J and Groza M and Zhu J and Christoforou A and Johnson SA and Khambatta G and Narla RK and Nimje RY and Huang D and Dodd DS and Griffin J and Miseo G and Whitefield B and Weiss DR and Rader J and Kuzu E and Leisten J and Lai C and Shi L and Del Rosario J and Dalvie D and Rolfe M and Zapf CW and Belmont P and Alexander M and Bence N and Groocock L},
  year = {2026},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.5c03123},
  url = {https://doi.org/10.1021/acs.jmedchem.5c03123}
}

RIS

TY  - JOUR
TI  - Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma.
AU  - Mortensen DS
AU  - Shunatona HP
AU  - Holmberg-Douglas N
AU  - Rhodes J
AU  - Da Silva D
AU  - Gamez J
AU  - Groza M
AU  - Zhu J
AU  - Christoforou A
AU  - Johnson SA
AU  - Khambatta G
AU  - Narla RK
AU  - Nimje RY
AU  - Huang D
AU  - Dodd DS
AU  - Griffin J
AU  - Miseo G
AU  - Whitefield B
AU  - Weiss DR
AU  - Rader J
AU  - Kuzu E
AU  - Leisten J
AU  - Lai C
AU  - Shi L
AU  - Del Rosario J
AU  - Dalvie D
AU  - Rolfe M
AU  - Zapf CW
AU  - Belmont P
AU  - Alexander M
AU  - Bence N
AU  - Groocock L
PY  - 2026
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.5c03123
UR  - https://doi.org/10.1021/acs.jmedchem.5c03123
ER  -

APA

DS, M., HP, S., N, H., J, R., D, D. S., J, G., M, G., J, Z., A, C., SA, J., G, K., RK, N., RY, N., D, H., DS, D., J, G., G, M., B, W., DR, W., J, R., E, K., J, L., C, L., L, S., J, D. R., D, D., M, R., CW, Z., P, B., M, A., N, B., & L, G. (2026). Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.5c03123

Source records

pubmed · retrieved 2026-11-10T19:14:45.846Z