Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer

James Neef, Kimberly S. Straley, Chinmoy Mukherjee, Amol Tipnis, Suleman Riyajsaheb Maujan, Maulasri Bhatta, Sambad Sharma, Sara Sinicropi-Yao, Joe DeBartolo, Andrew J. McRiner, Betty Chan, Henry Wilson, Christina S. Lee, Zied Boudhraa, Mohamed El Ezzy, Mark Bittinger, Laura Jennings Antipov, Thomas G. Graeber, Katharine E. Yen, David S. Millan

Open source

DOI: 10.1021/acs.jmedchem.5c03208
Published: 2026-02-09
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c03208,
  title = {Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer},
  author = {James Neef and Kimberly S. Straley and Chinmoy Mukherjee and Amol Tipnis and Suleman Riyajsaheb Maujan and Maulasri Bhatta and Sambad Sharma and Sara Sinicropi-Yao and Joe DeBartolo and Andrew J. McRiner and Betty Chan and Henry Wilson and Christina S. Lee and Zied Boudhraa and Mohamed El Ezzy and Mark Bittinger and Laura Jennings Antipov and Thomas G. Graeber and Katharine E. Yen and David S. Millan},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.5c03208},
  url = {https://doi.org/10.1021/acs.jmedchem.5c03208}
}

RIS

TY  - JOUR
TI  - Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer
AU  - James Neef
AU  - Kimberly S. Straley
AU  - Chinmoy Mukherjee
AU  - Amol Tipnis
AU  - Suleman Riyajsaheb Maujan
AU  - Maulasri Bhatta
AU  - Sambad Sharma
AU  - Sara Sinicropi-Yao
AU  - Joe DeBartolo
AU  - Andrew J. McRiner
AU  - Betty Chan
AU  - Henry Wilson
AU  - Christina S. Lee
AU  - Zied Boudhraa
AU  - Mohamed El Ezzy
AU  - Mark Bittinger
AU  - Laura Jennings Antipov
AU  - Thomas G. Graeber
AU  - Katharine E. Yen
AU  - David S. Millan
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.5c03208
UR  - https://doi.org/10.1021/acs.jmedchem.5c03208
ER  -

APA

Neef, J., Straley, K. S., Mukherjee, C., Tipnis, A., Maujan, S. R., Bhatta, M., Sharma, S., Sinicropi-Yao, S., DeBartolo, J., McRiner, A. J., Chan, B., Wilson, H., Lee, C. S., Boudhraa, Z., Ezzy, M. E., Bittinger, M., Antipov, L. J., Graeber, T. G., Yen, K. E., & Millan, D. S. (2026). Discovery and Optimization of Orally Bioavailable Heterobifunctional Degraders of KAT2A/B for the Treatment of Cancer. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.5c03208

Source records

crossref · retrieved 2026-09-27T16:48:46.655Z