Optimization of Covalent 6-Cyanoquinazoline KRAS <sup>G12C</sup> Inhibitors for the Treatment of Solid Tumors

Jesse P. Waldo, Paul J. Krawczuk, Christopher B. Kelly, Christopher G. Callas, Justin S. Cisar, Wendy Eccles, Carlos A. Guerrero, Michael D. Hack, William M. Jones, Colleen E. Keohane, Lian-Sheng Li, Sanath Meegalla, Rosaura Padilla-Salinas, Robert J. Rosano, Kirk W. Shimkin, Yvan R. F. Simonnet, Doree Sitkoff, Anasheh Sookezian, Michael P. Winters, Tammy L. Bush, Sheldon T. Cheung, Amanda M. Del Rosario, Rasmus Hansen, Matthew R. Janes, Haleema Janjua, Faraz Kazmi, Robert Kirkpatrick, David La, Ryan Lenhart, Matthew V. Lorenzi, Yi Liu, Natalie Mesens, Cynthia M. Milligan, Heather Murrey, Ulf Peters, Pingda Ren, Mark Richter, Michele Rizzolio, Swetha Rao, Paul Shaffer, Christopher F. Stratton, Lawrence M. Szewczuk, Jenny Wen, Victoria Wong, Carol Yanovich, Sylvie Laquerre, James P. Edwards, Kristi A. Leonard

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DOI: 10.1021/acs.jmedchem.5c03610
Published: 2026-04-01
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.5c03610,
  title = {Optimization of Covalent 6-Cyanoquinazoline KRAS
                    <sup>G12C</sup>
                    Inhibitors for the Treatment of Solid Tumors},
  author = {Jesse P. Waldo and Paul J. Krawczuk and Christopher B. Kelly and Christopher G. Callas and Justin S. Cisar and Wendy Eccles and Carlos A. Guerrero and Michael D. Hack and William M. Jones and Colleen E. Keohane and Lian-Sheng Li and Sanath Meegalla and Rosaura Padilla-Salinas and Robert J. Rosano and Kirk W. Shimkin and Yvan R. F. Simonnet and Doree Sitkoff and Anasheh Sookezian and Michael P. Winters and Tammy L. Bush and Sheldon T. Cheung and Amanda M. Del Rosario and Rasmus Hansen and Matthew R. Janes and Haleema Janjua and Faraz Kazmi and Robert Kirkpatrick and David La and Ryan Lenhart and Matthew V. Lorenzi and Yi Liu and Natalie Mesens and Cynthia M. Milligan and Heather Murrey and Ulf Peters and Pingda Ren and Mark Richter and Michele Rizzolio and Swetha Rao and Paul Shaffer and Christopher F. Stratton and Lawrence M. Szewczuk and Jenny Wen and Victoria Wong and Carol Yanovich and Sylvie Laquerre and James P. Edwards and Kristi A. Leonard},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.5c03610},
  url = {https://doi.org/10.1021/acs.jmedchem.5c03610}
}

RIS

TY  - JOUR
TI  - Optimization of Covalent 6-Cyanoquinazoline KRAS
                    <sup>G12C</sup>
                    Inhibitors for the Treatment of Solid Tumors
AU  - Jesse P. Waldo
AU  - Paul J. Krawczuk
AU  - Christopher B. Kelly
AU  - Christopher G. Callas
AU  - Justin S. Cisar
AU  - Wendy Eccles
AU  - Carlos A. Guerrero
AU  - Michael D. Hack
AU  - William M. Jones
AU  - Colleen E. Keohane
AU  - Lian-Sheng Li
AU  - Sanath Meegalla
AU  - Rosaura Padilla-Salinas
AU  - Robert J. Rosano
AU  - Kirk W. Shimkin
AU  - Yvan R. F. Simonnet
AU  - Doree Sitkoff
AU  - Anasheh Sookezian
AU  - Michael P. Winters
AU  - Tammy L. Bush
AU  - Sheldon T. Cheung
AU  - Amanda M. Del Rosario
AU  - Rasmus Hansen
AU  - Matthew R. Janes
AU  - Haleema Janjua
AU  - Faraz Kazmi
AU  - Robert Kirkpatrick
AU  - David La
AU  - Ryan Lenhart
AU  - Matthew V. Lorenzi
AU  - Yi Liu
AU  - Natalie Mesens
AU  - Cynthia M. Milligan
AU  - Heather Murrey
AU  - Ulf Peters
AU  - Pingda Ren
AU  - Mark Richter
AU  - Michele Rizzolio
AU  - Swetha Rao
AU  - Paul Shaffer
AU  - Christopher F. Stratton
AU  - Lawrence M. Szewczuk
AU  - Jenny Wen
AU  - Victoria Wong
AU  - Carol Yanovich
AU  - Sylvie Laquerre
AU  - James P. Edwards
AU  - Kristi A. Leonard
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.5c03610
UR  - https://doi.org/10.1021/acs.jmedchem.5c03610
ER  -

APA

Waldo, J. P., Krawczuk, P. J., Kelly, C. B., Callas, C. G., Cisar, J. S., Eccles, W., Guerrero, C. A., Hack, M. D., Jones, W. M., Keohane, C. E., Li, L., Meegalla, S., Padilla-Salinas, R., Rosano, R. J., Shimkin, K. W., Simonnet, Y. R. F., Sitkoff, D., Sookezian, A., Winters, M. P., Bush, T. L., Cheung, S. T., Rosario, A. M. D., Hansen, R., Janes, M. R., Janjua, H., Kazmi, F., Kirkpatrick, R., La, D., Lenhart, R., Lorenzi, M. V., Liu, Y., Mesens, N., Milligan, C. M., Murrey, H., Peters, U., Ren, P., Richter, M., Rizzolio, M., Rao, S., Shaffer, P., Stratton, C. F., Szewczuk, L. M., Wen, J., Wong, V., Yanovich, C., Laquerre, S., Edwards, J. P., & Leonard, K. A. (2026). Optimization of Covalent 6-Cyanoquinazoline KRAS <sup>G12C</sup> Inhibitors for the Treatment of Solid Tumors. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.5c03610

Source records

crossref · retrieved 2026-09-27T13:22:42.485Z