Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).

Bradbury RH, Callis R, Carr GR, Chen H, Clark E, Feron L, Glossop S, Graham MA, Hattersley M, Jones C, Lamont SG, Ouvry G, Patel A, Patel J, Rabow AA, Roberts CA, Stokes S, Stratton N, Walker GE, Ward L, Whalley D, Whittaker D, Wrigley G, Waring MJ

Open source

DOI: 10.1021/acs.jmedchem.6b00070
Published: 2016 Sep 8
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6b00070,
  title = {Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).},
  author = {Bradbury RH and Callis R and Carr GR and Chen H and Clark E and Feron L and Glossop S and Graham MA and Hattersley M and Jones C and Lamont SG and Ouvry G and Patel A and Patel J and Rabow AA and Roberts CA and Stokes S and Stratton N and Walker GE and Ward L and Whalley D and Whittaker D and Wrigley G and Waring MJ},
  year = {2016},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.6b00070},
  url = {https://doi.org/10.1021/acs.jmedchem.6b00070}
}

RIS

TY  - JOUR
TI  - Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
AU  - Bradbury RH
AU  - Callis R
AU  - Carr GR
AU  - Chen H
AU  - Clark E
AU  - Feron L
AU  - Glossop S
AU  - Graham MA
AU  - Hattersley M
AU  - Jones C
AU  - Lamont SG
AU  - Ouvry G
AU  - Patel A
AU  - Patel J
AU  - Rabow AA
AU  - Roberts CA
AU  - Stokes S
AU  - Stratton N
AU  - Walker GE
AU  - Ward L
AU  - Whalley D
AU  - Whittaker D
AU  - Wrigley G
AU  - Waring MJ
PY  - 2016
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.6b00070
UR  - https://doi.org/10.1021/acs.jmedchem.6b00070
ER  -

APA

RH, B., R, C., GR, C., H, C., E, C., L, F., S, G., MA, G., M, H., C, J., SG, L., G, O., A, P., J, P., AA, R., CA, R., S, S., N, S., GE, W., L, W., D, W., D, W., G, W., & MJ, W. (2016). Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.6b00070

Source records

pubmed · retrieved 2026-09-26T20:06:00.758Z