Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR.

Josien H, Nair AG, Ding FX, Guo Y, Chen YH, Rao AU, Liu J, Tong L, Sun Z, Lo MM, Tucker TJ, Embrey MW, Shahripour A, Wu C, Bianchi E, Branca D, Kuethe JT, Lee J, Thaisrivongs DA, Bulger PG, Zhu X, Ha SN, Johnston JM, Klein DJ, Orth P, Hong MR, Buevich AV, Gao Q, Zokian HJ, Koeplinger KA, Tracy RW, Hafey MJ, Buist N, Bueters T, Alleyne C, Bass A, Campeau LC, Johns DG, Garbaccio RM, Vachal P, Walji A, Wood HB.

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DOI: 10.1021/acs.jmedchem.6c00463
Published: 2026-05-27
Container: J Med Chem
Publisher: Not recorded
Open access: no

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00463,
  title = {Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR.},
  author = {Josien H and  Nair AG and  Ding FX and  Guo Y and  Chen YH and  Rao AU and  Liu J and  Tong L and  Sun Z and  Lo MM and  Tucker TJ and  Embrey MW and  Shahripour A and  Wu C and  Bianchi E and  Branca D and  Kuethe JT and  Lee J and  Thaisrivongs DA and  Bulger PG and  Zhu X and  Ha SN and  Johnston JM and  Klein DJ and  Orth P and  Hong MR and  Buevich AV and  Gao Q and  Zokian HJ and  Koeplinger KA and  Tracy RW and  Hafey MJ and  Buist N and  Bueters T and  Alleyne C and  Bass A and  Campeau LC and  Johns DG and  Garbaccio RM and  Vachal P and  Walji A and  Wood HB.},
  year = {2026},
  journal = {J Med Chem},
  doi = {10.1021/acs.jmedchem.6c00463},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00463}
}

RIS

TY  - JOUR
TI  - Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR.
AU  - Josien H
AU  -  Nair AG
AU  -  Ding FX
AU  -  Guo Y
AU  -  Chen YH
AU  -  Rao AU
AU  -  Liu J
AU  -  Tong L
AU  -  Sun Z
AU  -  Lo MM
AU  -  Tucker TJ
AU  -  Embrey MW
AU  -  Shahripour A
AU  -  Wu C
AU  -  Bianchi E
AU  -  Branca D
AU  -  Kuethe JT
AU  -  Lee J
AU  -  Thaisrivongs DA
AU  -  Bulger PG
AU  -  Zhu X
AU  -  Ha SN
AU  -  Johnston JM
AU  -  Klein DJ
AU  -  Orth P
AU  -  Hong MR
AU  -  Buevich AV
AU  -  Gao Q
AU  -  Zokian HJ
AU  -  Koeplinger KA
AU  -  Tracy RW
AU  -  Hafey MJ
AU  -  Buist N
AU  -  Bueters T
AU  -  Alleyne C
AU  -  Bass A
AU  -  Campeau LC
AU  -  Johns DG
AU  -  Garbaccio RM
AU  -  Vachal P
AU  -  Walji A
AU  -  Wood HB.
PY  - 2026
JO  - J Med Chem
DO  - 10.1021/acs.jmedchem.6c00463
UR  - https://doi.org/10.1021/acs.jmedchem.6c00463
ER  -

APA

H, J., AG, N., FX, D., Y, G., YH, C., AU, R., J, L., L, T., Z, S., MM, L., TJ, T., MW, E., A, S., C, W., E, B., D, B., JT, K., J, L., DA, T., PG, B., X, Z., SN, H., JM, J., DJ, K., P, O., MR, H., AV, B., Q, G., HJ, Z., KA, K., RW, T., MJ, H., N, B., T, B., C, A., A, B., LC, C., DG, J., RM, G., P, V., A, W., & HB., W. (2026). Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR.. J Med Chem. https://doi.org/10.1021/acs.jmedchem.6c00463

Source records

europe-pmc · retrieved 2026-09-26T01:09:16.206Z