Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.

Torrente E, Quotadamo A, Corio A, Ferrigno F, Ievoli G, Montalbetti C, Vasile S, Graziani R, Paonessa G, Alli C, Bisbocci M, Veneziano M, Proto G, Orsale MV, di Marco A, Toniatti C, Ontoria JM

Open source

DOI: 10.1021/acs.jmedchem.6c00476
Published: 2026 Jun 11
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00476,
  title = {Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.},
  author = {Torrente E and Quotadamo A and Corio A and Ferrigno F and Ievoli G and Montalbetti C and Vasile S and Graziani R and Paonessa G and Alli C and Bisbocci M and Veneziano M and Proto G and Orsale MV and di Marco A and Toniatti C and Ontoria JM},
  year = {2026},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.6c00476},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00476}
}

RIS

TY  - JOUR
TI  - Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.
AU  - Torrente E
AU  - Quotadamo A
AU  - Corio A
AU  - Ferrigno F
AU  - Ievoli G
AU  - Montalbetti C
AU  - Vasile S
AU  - Graziani R
AU  - Paonessa G
AU  - Alli C
AU  - Bisbocci M
AU  - Veneziano M
AU  - Proto G
AU  - Orsale MV
AU  - di Marco A
AU  - Toniatti C
AU  - Ontoria JM
PY  - 2026
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.6c00476
UR  - https://doi.org/10.1021/acs.jmedchem.6c00476
ER  -

APA

E, T., A, Q., A, C., F, F., G, I., C, M., S, V., R, G., G, P., C, A., M, B., M, V., G, P., MV, O., A, D. M., C, T., & JM, O. (2026). Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.6c00476

Source records

pubmed · retrieved 2026-09-26T10:19:50.336Z