Discovery of LG-NE-29: An Orally Bioavailable GSPT1 Molecular Glue Degrader Effective in Glioblastoma Xenograft Models.

Shi T, Pei Y, Peng B, Wu Z, Feng Y, Zhao Y, Luo Y, Chen Q, Chen S, Xu J, Shao Z, Liu Y, Gong X, Yang S, Zou X, Zhou L, Zhao Y, Jiang H, Xu C, Meng Z, Lu W, Su Z

Open source

DOI: 10.1021/acs.jmedchem.6c00544
Published: 2026 Oct 22
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: no

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00544,
  title = {Discovery of LG-NE-29: An Orally Bioavailable GSPT1 Molecular Glue Degrader Effective in Glioblastoma Xenograft Models.},
  author = {Shi T and Pei Y and Peng B and Wu Z and Feng Y and Zhao Y and Luo Y and Chen Q and Chen S and Xu J and Shao Z and Liu Y and Gong X and Yang S and Zou X and Zhou L and Zhao Y and Jiang H and Xu C and Meng Z and Lu W and Su Z},
  year = {2026},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.6c00544},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00544}
}

RIS

TY  - JOUR
TI  - Discovery of LG-NE-29: An Orally Bioavailable GSPT1 Molecular Glue Degrader Effective in Glioblastoma Xenograft Models.
AU  - Shi T
AU  - Pei Y
AU  - Peng B
AU  - Wu Z
AU  - Feng Y
AU  - Zhao Y
AU  - Luo Y
AU  - Chen Q
AU  - Chen S
AU  - Xu J
AU  - Shao Z
AU  - Liu Y
AU  - Gong X
AU  - Yang S
AU  - Zou X
AU  - Zhou L
AU  - Zhao Y
AU  - Jiang H
AU  - Xu C
AU  - Meng Z
AU  - Lu W
AU  - Su Z
PY  - 2026
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.6c00544
UR  - https://doi.org/10.1021/acs.jmedchem.6c00544
ER  -

APA

T, S., Y, P., B, P., Z, W., Y, F., Y, Z., Y, L., Q, C., S, C., J, X., Z, S., Y, L., X, G., S, Y., X, Z., L, Z., Y, Z., H, J., C, X., Z, M., W, L., & Z, S. (2026). Discovery of LG-NE-29: An Orally Bioavailable GSPT1 Molecular Glue Degrader Effective in Glioblastoma Xenograft Models.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.6c00544

Source records

pubmed · retrieved 2026-11-10T14:14:35.617Z
europe-pmc · retrieved 2026-11-10T14:14:35.621Z