Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Read BJ, Ewens C, Gigante F, Thomas J, Felisberto-Rodrigues C, Alvarez Peres S, Tighe C, de Las Heras Ruiz E, Schiemann K, Malcolm AG, McAndrew PC, Stubbs M, Patani H, Costa HDS, Stoodley K, Pickard L, Busch M, Gunnell E, Silva S, Knopp A, Hallett ST, Augustin M, Lammens A, Carter M, Meniconi M, Ballarotto M, Ainsley J, Meister P, Sethi D, Burke R, Scarpino A, Le Bihan YV, Grädler U, Blagg J, Workman P, Clarke PA, Blum A, Esdar C, Bhalay G, van Montfort RLM

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DOI: 10.1021/acs.jmedchem.6c00732
Published: 2026 Aug 13
Container: Journal of medicinal chemistry
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00732,
  title = {Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.},
  author = {Read BJ and Ewens C and Gigante F and Thomas J and Felisberto-Rodrigues C and Alvarez Peres S and Tighe C and de Las Heras Ruiz E and Schiemann K and Malcolm AG and McAndrew PC and Stubbs M and Patani H and Costa HDS and Stoodley K and Pickard L and Busch M and Gunnell E and Silva S and Knopp A and Hallett ST and Augustin M and Lammens A and Carter M and Meniconi M and Ballarotto M and Ainsley J and Meister P and Sethi D and Burke R and Scarpino A and Le Bihan YV and Grädler U and Blagg J and Workman P and Clarke PA and Blum A and Esdar C and Bhalay G and van Montfort RLM},
  year = {2026},
  journal = {Journal of medicinal chemistry},
  doi = {10.1021/acs.jmedchem.6c00732},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00732}
}

RIS

TY  - JOUR
TI  - Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.
AU  - Read BJ
AU  - Ewens C
AU  - Gigante F
AU  - Thomas J
AU  - Felisberto-Rodrigues C
AU  - Alvarez Peres S
AU  - Tighe C
AU  - de Las Heras Ruiz E
AU  - Schiemann K
AU  - Malcolm AG
AU  - McAndrew PC
AU  - Stubbs M
AU  - Patani H
AU  - Costa HDS
AU  - Stoodley K
AU  - Pickard L
AU  - Busch M
AU  - Gunnell E
AU  - Silva S
AU  - Knopp A
AU  - Hallett ST
AU  - Augustin M
AU  - Lammens A
AU  - Carter M
AU  - Meniconi M
AU  - Ballarotto M
AU  - Ainsley J
AU  - Meister P
AU  - Sethi D
AU  - Burke R
AU  - Scarpino A
AU  - Le Bihan YV
AU  - Grädler U
AU  - Blagg J
AU  - Workman P
AU  - Clarke PA
AU  - Blum A
AU  - Esdar C
AU  - Bhalay G
AU  - van Montfort RLM
PY  - 2026
JO  - Journal of medicinal chemistry
DO  - 10.1021/acs.jmedchem.6c00732
UR  - https://doi.org/10.1021/acs.jmedchem.6c00732
ER  -

APA

BJ, R., C, E., F, G., J, T., C, F., S, A. P., C, T., E, D. L. H. R., K, S., AG, M., PC, M., M, S., H, P., HDS, C., K, S., L, P., M, B., E, G., S, S., A, K., ST, H., M, A., A, L., M, C., M, M., M, B., J, A., P, M., D, S., R, B., A, S., YV, L. B., U, G., J, B., P, W., PA, C., A, B., C, E., G, B., & RLM, V. M. (2026). Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.6c00732

Source records

pubmed · retrieved 2026-09-26T09:23:49.221Z