Dysregulation of Human ClpP Using Small Molecules with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma Therapy Validated by Patient-Derived Tumor Organoids

Morena Miciaccia, Domenico Armenise, Olga Maria Baldelli, Anselma Liturri, Mariachiara Mammone, Giovanni Graziano, Marialessandra Contino, Francesca Rizzo, Paola Loguercio Polosa, Francesco Bruni, Clémence Deligne, Laura Broutier, Gianfranco Cavallaro, Cosimo Gianluca Fortuna, Anna Tolomeo, Cadell Green, Alessandro Bonifazi, Emily M. Majaesic, Marim M. Barghash, Nok Pang Josh Lee, Carmen Gratteri, Carmine Talarico, Silvana Filieri, Giuseppe Micalizzi, Danilo Donnarumma, Paola Dugo, Luigi Mondello, Anna Maria Sardanelli, Walid A. Houry, Javad Nazarian, Savina Ferorelli, Maria Grazia Perrone, Antonio Scilimati

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DOI: 10.1021/acs.jmedchem.6c00777
Published: 2026-07-08
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00777,
  title = {Dysregulation
of Human ClpP Using Small Molecules
with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma
Therapy Validated by Patient-Derived Tumor Organoids},
  author = {Morena Miciaccia and Domenico Armenise and Olga Maria Baldelli and Anselma Liturri and Mariachiara Mammone and Giovanni Graziano and Marialessandra Contino and Francesca Rizzo and Paola Loguercio Polosa and Francesco Bruni and Clémence Deligne and Laura Broutier and Gianfranco Cavallaro and Cosimo Gianluca Fortuna and Anna Tolomeo and Cadell Green and Alessandro Bonifazi and Emily M. Majaesic and Marim M. Barghash and Nok Pang Josh Lee and Carmen Gratteri and Carmine Talarico and Silvana Filieri and Giuseppe Micalizzi and Danilo Donnarumma and Paola Dugo and Luigi Mondello and Anna Maria Sardanelli and Walid A. Houry and Javad Nazarian and Savina Ferorelli and Maria Grazia Perrone and Antonio Scilimati},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c00777},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00777}
}

RIS

TY  - JOUR
TI  - Dysregulation
of Human ClpP Using Small Molecules
with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma
Therapy Validated by Patient-Derived Tumor Organoids
AU  - Morena Miciaccia
AU  - Domenico Armenise
AU  - Olga Maria Baldelli
AU  - Anselma Liturri
AU  - Mariachiara Mammone
AU  - Giovanni Graziano
AU  - Marialessandra Contino
AU  - Francesca Rizzo
AU  - Paola Loguercio Polosa
AU  - Francesco Bruni
AU  - Clémence Deligne
AU  - Laura Broutier
AU  - Gianfranco Cavallaro
AU  - Cosimo Gianluca Fortuna
AU  - Anna Tolomeo
AU  - Cadell Green
AU  - Alessandro Bonifazi
AU  - Emily M. Majaesic
AU  - Marim M. Barghash
AU  - Nok Pang Josh Lee
AU  - Carmen Gratteri
AU  - Carmine Talarico
AU  - Silvana Filieri
AU  - Giuseppe Micalizzi
AU  - Danilo Donnarumma
AU  - Paola Dugo
AU  - Luigi Mondello
AU  - Anna Maria Sardanelli
AU  - Walid A. Houry
AU  - Javad Nazarian
AU  - Savina Ferorelli
AU  - Maria Grazia Perrone
AU  - Antonio Scilimati
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c00777
UR  - https://doi.org/10.1021/acs.jmedchem.6c00777
ER  -

APA

Miciaccia, M., Armenise, D., Baldelli, O. M., Liturri, A., Mammone, M., Graziano, G., Contino, M., Rizzo, F., Polosa, P. L., Bruni, F., Deligne, C., Broutier, L., Cavallaro, G., Fortuna, C. G., Tolomeo, A., Green, C., Bonifazi, A., Majaesic, E. M., Barghash, M. M., Lee, N. P. J., Gratteri, C., Talarico, C., Filieri, S., Micalizzi, G., Donnarumma, D., Dugo, P., Mondello, L., Sardanelli, A. M., Houry, W. A., Nazarian, J., Ferorelli, S., Perrone, M. G., & Scilimati, A. (2026). Dysregulation of Human ClpP Using Small Molecules with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma Therapy Validated by Patient-Derived Tumor Organoids. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c00777

Source records

crossref · retrieved 2026-09-26T04:56:50.632Z