Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites

Barbara Forte, Fiona Bellany, Peter S. Campbell, Giulia Chemi, Alice Dawson, Mark Anderson, Yaw Aniweh, Anna Y. Burkhard, Anna Caroline Campos Aguiar, Alisje Churchyard, Caitlin A. Cooper, Amália dos Santos Ferreira, Mufuliat Toyin Famodimu, Francis G. Fang, Xiao Hu, Tonnie Huijs, Delphine Baud, Chimed Jansen, María Belén Jiménez Díaz, Roger Bonnert, Susan Boyd, Benigno Crespo-Fernández, Branko Mitasev, Simone Montagna, Sachel Mok, Dinakaran Murugesan, Sunil K. Narwal, Neil R. Norcross, John Okombo, Heekuk Park, Caroline Peet, Dhelio B. Pereira, John M. Post, Janette Reader, Jennifer Riley, David A. Robinson, Raku Shinkyo, Frederick R.C. Simeons, Laura Simpson, Alasdair Smith, Dennis Smith, Josefine Striepen, Carolina B.G. Teles, Rianne van der Laak, Anne-Catrin Uhlemann, Amélie Vantaux, Caroline Wilson, Benoît Witkowski, Gavin Wood, Tomas Yeo, Fabio Zuccotto, Iñigo Angulo-Barturen, Jake Baum, Judith M. Bolscher, Rafael Victorio Carvalho Guido, Lyn-Marié Birkholtz, Michael J. Delves, Laurent Dembele, David A. Fidock, Francisco Javier Gamo, Dennis E. Kyle, Steven P. Maher, Jean Popovici, Chris Walpole, Fabian Gusovsky, Paul A. Willis, Kevin D. Read, Ian H. Gilbert, Beatriz Baragaña

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DOI: 10.1021/acs.jmedchem.6c00823
Published: 2026-06-02
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00823,
title = {Structure-Guided
Optimization of Novel Inhibitors
of
Plasmodium
Lysyl-tRNA Synthetase
with Multistage Activity against Malaria Parasites},
author = {Barbara Forte and Fiona Bellany and Peter S. Campbell and Giulia Chemi and Alice Dawson and Mark Anderson and Yaw Aniweh and Anna Y. Burkhard and Anna Caroline Campos Aguiar and Alisje Churchyard and Caitlin A. Cooper and Amália dos Santos Ferreira and Mufuliat Toyin Famodimu and Francis G. Fang and Xiao Hu and Tonnie Huijs and Delphine Baud and Chimed Jansen and María Belén Jiménez Díaz and Roger Bonnert and Susan Boyd and Benigno Crespo-Fernández and Branko Mitasev and Simone Montagna and Sachel Mok and Dinakaran Murugesan and Sunil K. Narwal and Neil R. Norcross and John Okombo and Heekuk Park and Caroline Peet and Dhelio B. Pereira and John M. Post and Janette Reader and Jennifer Riley and David A. Robinson and Raku Shinkyo and Frederick R.C. Simeons and Laura Simpson and Alasdair Smith and Dennis Smith and Josefine Striepen and Carolina B.G. Teles and Rianne van der Laak and Anne-Catrin Uhlemann and Amélie Vantaux and Caroline Wilson and Benoît Witkowski and Gavin Wood and Tomas Yeo and Fabio Zuccotto and Iñigo Angulo-Barturen and Jake Baum and Judith M. Bolscher and Rafael Victorio Carvalho Guido and Lyn-Marié Birkholtz and Michael J. Delves and Laurent Dembele and David A. Fidock and Francisco Javier Gamo and Dennis E. Kyle and Steven P. Maher and Jean Popovici and Chris Walpole and Fabian Gusovsky and Paul A. Willis and Kevin D. Read and Ian H. Gilbert and Beatriz Baragaña},
year = {2026},
journal = {Journal of Medicinal Chemistry},
doi = {10.1021/acs.jmedchem.6c00823},
url = {https://doi.org/10.1021/acs.jmedchem.6c00823}
}

RIS

TY  - JOUR
TI  - Structure-Guided
Optimization of Novel Inhibitors
of
                    <i>Plasmodium</i>
                    Lysyl-tRNA Synthetase
with Multistage Activity against Malaria Parasites
AU  - Barbara Forte
AU  - Fiona Bellany
AU  - Peter S. Campbell
AU  - Giulia Chemi
AU  - Alice Dawson
AU  - Mark Anderson
AU  - Yaw Aniweh
AU  - Anna Y. Burkhard
AU  - Anna Caroline Campos Aguiar
AU  - Alisje Churchyard
AU  - Caitlin A. Cooper
AU  - Amália dos Santos Ferreira
AU  - Mufuliat Toyin Famodimu
AU  - Francis G. Fang
AU  - Xiao Hu
AU  - Tonnie Huijs
AU  - Delphine Baud
AU  - Chimed Jansen
AU  - María Belén Jiménez Díaz
AU  - Roger Bonnert
AU  - Susan Boyd
AU  - Benigno Crespo-Fernández
AU  - Branko Mitasev
AU  - Simone Montagna
AU  - Sachel Mok
AU  - Dinakaran Murugesan
AU  - Sunil K. Narwal
AU  - Neil R. Norcross
AU  - John Okombo
AU  - Heekuk Park
AU  - Caroline Peet
AU  - Dhelio B. Pereira
AU  - John M. Post
AU  - Janette Reader
AU  - Jennifer Riley
AU  - David A. Robinson
AU  - Raku Shinkyo
AU  - Frederick R.C. Simeons
AU  - Laura Simpson
AU  - Alasdair Smith
AU  - Dennis Smith
AU  - Josefine Striepen
AU  - Carolina B.G. Teles
AU  - Rianne van der Laak
AU  - Anne-Catrin Uhlemann
AU  - Amélie Vantaux
AU  - Caroline Wilson
AU  - Benoît Witkowski
AU  - Gavin Wood
AU  - Tomas Yeo
AU  - Fabio Zuccotto
AU  - Iñigo Angulo-Barturen
AU  - Jake Baum
AU  - Judith M. Bolscher
AU  - Rafael Victorio Carvalho Guido
AU  - Lyn-Marié Birkholtz
AU  - Michael J. Delves
AU  - Laurent Dembele
AU  - David A. Fidock
AU  - Francisco Javier Gamo
AU  - Dennis E. Kyle
AU  - Steven P. Maher
AU  - Jean Popovici
AU  - Chris Walpole
AU  - Fabian Gusovsky
AU  - Paul A. Willis
AU  - Kevin D. Read
AU  - Ian H. Gilbert
AU  - Beatriz Baragaña
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c00823
UR  - https://doi.org/10.1021/acs.jmedchem.6c00823
ER  -

APA

Forte, B., Bellany, F., Campbell, P. S., Chemi, G., Dawson, A., Anderson, M., Aniweh, Y., Burkhard, A. Y., Aguiar, A. C. C., Churchyard, A., Cooper, C. A., Ferreira, A. D. S., Famodimu, M. T., Fang, F. G., Hu, X., Huijs, T., Baud, D., Jansen, C., Díaz, M. B. J., Bonnert, R., Boyd, S., Crespo-Fernández, B., Mitasev, B., Montagna, S., Mok, S., Murugesan, D., Narwal, S. K., Norcross, N. R., Okombo, J., Park, H., Peet, C., Pereira, D. B., Post, J. M., Reader, J., Riley, J., Robinson, D. A., Shinkyo, R., Simeons, F. R., Simpson, L., Smith, A., Smith, D., Striepen, J., Teles, C. B., Laak, R. V. D., Uhlemann, A., Vantaux, A., Wilson, C., Witkowski, B., Wood, G., Yeo, T., Zuccotto, F., Angulo-Barturen, I., Baum, J., Bolscher, J. M., Guido, R. V. C., Birkholtz, L., Delves, M. J., Dembele, L., Fidock, D. A., Gamo, F. J., Kyle, D. E., Maher, S. P., Popovici, J., Walpole, C., Gusovsky, F., Willis, P. A., Read, K. D., Gilbert, I. H., & Baragaña, B. (2026). Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c00823

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crossref · retrieved 2026-09-26T10:18:27.769Z

Structure-Guided Optimization of Novel Inhibitors of <i>Plasmodium</i> Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites

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