Structure-Based Design of Potent TLR7/8/9 Triple Antagonists: Overcoming High Tissue Distribution and Reactive Metabolite Liabilities

Zhiwei Zhang, Fabian Dey, Haixia Liu, Markus G. Rudolph, Yafei Liu, Xiaoqing Wang, Weixing Zhang, Zhisen Zhang, Buyu Kou, Ge Zou, Taishan Hu, Daniel Schlatter, Andreas Ehler, Jörg Benz, Kristin Sokoll, Tina Kaiser, Bernard Gsell, Haiyuan Ding, Zhaohu Lin, Lina Zhu, Lue Dai, Fang Shen, Jianquan Wu, Xin Yu, Jieyu Dai, Hongxia Qiu, Tianyi Jiang, Kara G. Lassen, Hong C. Shen, Wei Zhu

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DOI: 10.1021/acs.jmedchem.6c00993
Published: 2026-07-22
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c00993,
  title = {Structure-Based
Design of Potent TLR7/8/9 Triple Antagonists:
Overcoming High Tissue Distribution and Reactive Metabolite Liabilities},
  author = {Zhiwei Zhang and Fabian Dey and Haixia Liu and Markus G. Rudolph and Yafei Liu and Xiaoqing Wang and Weixing Zhang and Zhisen Zhang and Buyu Kou and Ge Zou and Taishan Hu and Daniel Schlatter and Andreas Ehler and Jörg Benz and Kristin Sokoll and Tina Kaiser and Bernard Gsell and Haiyuan Ding and Zhaohu Lin and Lina Zhu and Lue Dai and Fang Shen and Jianquan Wu and Xin Yu and Jieyu Dai and Hongxia Qiu and Tianyi Jiang and Kara G. Lassen and Hong C. Shen and Wei Zhu},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c00993},
  url = {https://doi.org/10.1021/acs.jmedchem.6c00993}
}

RIS

TY  - JOUR
TI  - Structure-Based
Design of Potent TLR7/8/9 Triple Antagonists:
Overcoming High Tissue Distribution and Reactive Metabolite Liabilities
AU  - Zhiwei Zhang
AU  - Fabian Dey
AU  - Haixia Liu
AU  - Markus G. Rudolph
AU  - Yafei Liu
AU  - Xiaoqing Wang
AU  - Weixing Zhang
AU  - Zhisen Zhang
AU  - Buyu Kou
AU  - Ge Zou
AU  - Taishan Hu
AU  - Daniel Schlatter
AU  - Andreas Ehler
AU  - Jörg Benz
AU  - Kristin Sokoll
AU  - Tina Kaiser
AU  - Bernard Gsell
AU  - Haiyuan Ding
AU  - Zhaohu Lin
AU  - Lina Zhu
AU  - Lue Dai
AU  - Fang Shen
AU  - Jianquan Wu
AU  - Xin Yu
AU  - Jieyu Dai
AU  - Hongxia Qiu
AU  - Tianyi Jiang
AU  - Kara G. Lassen
AU  - Hong C. Shen
AU  - Wei Zhu
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c00993
UR  - https://doi.org/10.1021/acs.jmedchem.6c00993
ER  -

APA

Zhang, Z., Dey, F., Liu, H., Rudolph, M. G., Liu, Y., Wang, X., Zhang, W., Zhang, Z., Kou, B., Zou, G., Hu, T., Schlatter, D., Ehler, A., Benz, J., Sokoll, K., Kaiser, T., Gsell, B., Ding, H., Lin, Z., Zhu, L., Dai, L., Shen, F., Wu, J., Yu, X., Dai, J., Qiu, H., Jiang, T., Lassen, K. G., Shen, H. C., & Zhu, W. (2026). Structure-Based Design of Potent TLR7/8/9 Triple Antagonists: Overcoming High Tissue Distribution and Reactive Metabolite Liabilities. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c00993

Source records

crossref · retrieved 2026-09-26T15:59:21.608Z