Discovery of <b>PIPE-791</b> , A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders

Austin Chen, Christopher Baccei, Jill Baccei, Alexander Broadhead, Kym I. Lorrain, Michael M. Poon, Jeffrey Roppe, Thomas O. Schrader, Karin J. Stebbins, Lino Valdez, Yifeng Xiong, Daniel S. Lorrain

Open source

DOI: 10.1021/acs.jmedchem.6c01049
Published: 2026-06-29
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c01049,
  title = {Discovery of
                    <b>PIPE-791</b>
                    , A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders},
  author = {Austin Chen and Christopher Baccei and Jill Baccei and Alexander Broadhead and Kym I. Lorrain and Michael M. Poon and Jeffrey Roppe and Thomas O. Schrader and Karin J. Stebbins and Lino Valdez and Yifeng Xiong and Daniel S. Lorrain},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c01049},
  url = {https://doi.org/10.1021/acs.jmedchem.6c01049}
}

RIS

TY  - JOUR
TI  - Discovery of
                    <b>PIPE-791</b>
                    , A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders
AU  - Austin Chen
AU  - Christopher Baccei
AU  - Jill Baccei
AU  - Alexander Broadhead
AU  - Kym I. Lorrain
AU  - Michael M. Poon
AU  - Jeffrey Roppe
AU  - Thomas O. Schrader
AU  - Karin J. Stebbins
AU  - Lino Valdez
AU  - Yifeng Xiong
AU  - Daniel S. Lorrain
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c01049
UR  - https://doi.org/10.1021/acs.jmedchem.6c01049
ER  -

APA

Chen, A., Baccei, C., Baccei, J., Broadhead, A., Lorrain, K. I., Poon, M. M., Roppe, J., Schrader, T. O., Stebbins, K. J., Valdez, L., Xiong, Y., & Lorrain, D. S. (2026). Discovery of <b>PIPE-791</b> , A Potent and Brain-Penetrant Lysophosphatidic Acid Receptor 1 Antagonist with Slow Tight Binding Characteristics for the Treatment of Neuroinflammatory Disorders. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c01049

Source records

crossref · retrieved 2026-11-10T17:40:19.701Z