Discovery and Preclinical Characterization of I-0436650, a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers

Alina Ciammaichella, Francesca Puca, Danilo Fabbrini, Pietro Randazzo, Ilaria Rossetti, Alessio Sferrazza, Federica Ferrigno, Alessandro Grillo, Esther Torrente, Costanza Iaccarino, Jérôme Amaudrut, Antonella Cellucci, Annalise Di Marco, Simone Palombo, Simone Esposito, Monica Bisbocci, Maria Vittoria Orsale, Martina Nibbio, Antonino Missineo, Francesco Scalabrì, Valentina Fodale, Vincenzo Pucci, Cristina Alli, Romano Di Fabio, Christian Montalbetti, Alessandro Carugo, Carlo Toniatti, Alessia Petrocchi

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DOI: 10.1021/acs.jmedchem.6c01182
Published: 2026-07-30
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c01182,
  title = {Discovery and
Preclinical Characterization of I-0436650,
a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers},
  author = {Alina Ciammaichella and Francesca Puca and Danilo Fabbrini and Pietro Randazzo and Ilaria Rossetti and Alessio Sferrazza and Federica Ferrigno and Alessandro Grillo and Esther Torrente and Costanza Iaccarino and Jérôme Amaudrut and Antonella Cellucci and Annalise Di Marco and Simone Palombo and Simone Esposito and Monica Bisbocci and Maria Vittoria Orsale and Martina Nibbio and Antonino Missineo and Francesco Scalabrì and Valentina Fodale and Vincenzo Pucci and Cristina Alli and Romano Di Fabio and Christian Montalbetti and Alessandro Carugo and Carlo Toniatti and Alessia Petrocchi},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c01182},
  url = {https://doi.org/10.1021/acs.jmedchem.6c01182}
}

RIS

TY  - JOUR
TI  - Discovery and
Preclinical Characterization of I-0436650,
a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers
AU  - Alina Ciammaichella
AU  - Francesca Puca
AU  - Danilo Fabbrini
AU  - Pietro Randazzo
AU  - Ilaria Rossetti
AU  - Alessio Sferrazza
AU  - Federica Ferrigno
AU  - Alessandro Grillo
AU  - Esther Torrente
AU  - Costanza Iaccarino
AU  - Jérôme Amaudrut
AU  - Antonella Cellucci
AU  - Annalise Di Marco
AU  - Simone Palombo
AU  - Simone Esposito
AU  - Monica Bisbocci
AU  - Maria Vittoria Orsale
AU  - Martina Nibbio
AU  - Antonino Missineo
AU  - Francesco Scalabrì
AU  - Valentina Fodale
AU  - Vincenzo Pucci
AU  - Cristina Alli
AU  - Romano Di Fabio
AU  - Christian Montalbetti
AU  - Alessandro Carugo
AU  - Carlo Toniatti
AU  - Alessia Petrocchi
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c01182
UR  - https://doi.org/10.1021/acs.jmedchem.6c01182
ER  -

APA

Ciammaichella, A., Puca, F., Fabbrini, D., Randazzo, P., Rossetti, I., Sferrazza, A., Ferrigno, F., Grillo, A., Torrente, E., Iaccarino, C., Amaudrut, J., Cellucci, A., Marco, A. D., Palombo, S., Esposito, S., Bisbocci, M., Orsale, M. V., Nibbio, M., Missineo, A., Scalabrì, F., Fodale, V., Pucci, V., Alli, C., Fabio, R. D., Montalbetti, C., Carugo, A., Toniatti, C., & Petrocchi, A. (2026). Discovery and Preclinical Characterization of I-0436650, a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c01182

Source records

crossref · retrieved 2026-09-26T17:38:40.337Z