Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia

Jiaxu Zhou, Zhongtang Li, Xiaojiao Sun, Xiangyu Zhang, Yan He, Cheng Shi, Xiaowei Chi, Dehua Lu, Weiping Lyu, Siyu Xiu, Tingting Yang, Yanming Chen, Zhongwei Wang, Qi Li, Ruqiu Zheng, Jiarui Du, Yu Lin, Jinghao Yan, Tengfei Li, Chenzhong Liao, Liangren Zhang, Zhenming Liu

Open source

DOI: 10.1021/acs.jmedchem.6c01512
Published: 2026-06-30
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c01512,
  title = {Design and
Synthesis of a Novel Covalent Dihydropteridinone
Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor
for the Treatment of Chronic Myeloid Leukemia},
  author = {Jiaxu Zhou and Zhongtang Li and Xiaojiao Sun and Xiangyu Zhang and Yan He and Cheng Shi and Xiaowei Chi and Dehua Lu and Weiping Lyu and Siyu Xiu and Tingting Yang and Yanming Chen and Zhongwei Wang and Qi Li and Ruqiu Zheng and Jiarui Du and Yu Lin and Jinghao Yan and Tengfei Li and Chenzhong Liao and Liangren Zhang and Zhenming Liu},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c01512},
  url = {https://doi.org/10.1021/acs.jmedchem.6c01512}
}

RIS

TY  - JOUR
TI  - Design and
Synthesis of a Novel Covalent Dihydropteridinone
Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor
for the Treatment of Chronic Myeloid Leukemia
AU  - Jiaxu Zhou
AU  - Zhongtang Li
AU  - Xiaojiao Sun
AU  - Xiangyu Zhang
AU  - Yan He
AU  - Cheng Shi
AU  - Xiaowei Chi
AU  - Dehua Lu
AU  - Weiping Lyu
AU  - Siyu Xiu
AU  - Tingting Yang
AU  - Yanming Chen
AU  - Zhongwei Wang
AU  - Qi Li
AU  - Ruqiu Zheng
AU  - Jiarui Du
AU  - Yu Lin
AU  - Jinghao Yan
AU  - Tengfei Li
AU  - Chenzhong Liao
AU  - Liangren Zhang
AU  - Zhenming Liu
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c01512
UR  - https://doi.org/10.1021/acs.jmedchem.6c01512
ER  -

APA

Zhou, J., Li, Z., Sun, X., Zhang, X., He, Y., Shi, C., Chi, X., Lu, D., Lyu, W., Xiu, S., Yang, T., Chen, Y., Wang, Z., Li, Q., Zheng, R., Du, J., Lin, Y., Yan, J., Li, T., Liao, C., Zhang, L., & Liu, Z. (2026). Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c01512

Source records

crossref · retrieved 2026-09-26T13:02:23.459Z