Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy

Cecilia Sanchez-Santos, Alberto Jimenez-Amor, Loreto Martinez-Gonzalez, Vanesa Nozal, Raquel Martin-Morales, Elnaz Aledavood, Daniel Bausela, Kayla Merrigan, Karen Diaz-Palacios, Rezart Zhubi, Stefan Knapp, Francesc R. Garcia-Gonzalo, Carmen Rodriguez-Cueto, Carmen Gil, Eva de Lago, Ana Martinez

Open source

DOI: 10.1021/acs.jmedchem.6c01882
Published: 2026-07-28
Container: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acs.jmedchem.6c01882,
  title = {Selective Brain-Penetrant
TTBK1 Inhibitors Modulate
TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of
TDP-43 Proteinopathy},
  author = {Cecilia Sanchez-Santos and Alberto Jimenez-Amor and Loreto Martinez-Gonzalez and Vanesa Nozal and Raquel Martin-Morales and Elnaz Aledavood and Daniel Bausela and Kayla Merrigan and Karen Diaz-Palacios and Rezart Zhubi and Stefan Knapp and Francesc R. Garcia-Gonzalo and Carmen Rodriguez-Cueto and Carmen Gil and Eva de Lago and Ana Martinez},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c01882},
  url = {https://doi.org/10.1021/acs.jmedchem.6c01882}
}

RIS

TY  - JOUR
TI  - Selective Brain-Penetrant
TTBK1 Inhibitors Modulate
TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of
TDP-43 Proteinopathy
AU  - Cecilia Sanchez-Santos
AU  - Alberto Jimenez-Amor
AU  - Loreto Martinez-Gonzalez
AU  - Vanesa Nozal
AU  - Raquel Martin-Morales
AU  - Elnaz Aledavood
AU  - Daniel Bausela
AU  - Kayla Merrigan
AU  - Karen Diaz-Palacios
AU  - Rezart Zhubi
AU  - Stefan Knapp
AU  - Francesc R. Garcia-Gonzalo
AU  - Carmen Rodriguez-Cueto
AU  - Carmen Gil
AU  - Eva de Lago
AU  - Ana Martinez
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c01882
UR  - https://doi.org/10.1021/acs.jmedchem.6c01882
ER  -

APA

Sanchez-Santos, C., Jimenez-Amor, A., Martinez-Gonzalez, L., Nozal, V., Martin-Morales, R., Aledavood, E., Bausela, D., Merrigan, K., Diaz-Palacios, K., Zhubi, R., Knapp, S., Garcia-Gonzalo, F. R., Rodriguez-Cueto, C., Gil, C., Lago, E. D., & Martinez, A. (2026). Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c01882

Source records

crossref · retrieved 2026-09-27T11:28:00.177Z