From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.
- DOI
- 10.1021/acs.jmedchem.6c01913
- Published
- 2026 Sep 10
- Container
- Journal of medicinal chemistry
- Publisher
- Not recorded
- Open access
- yes
Credibility signals
limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.
Show all credibility signals
- cautionDOI registered: No matching Crossref record was present in this response.
- cautionDOI resolves: No matching Crossref record was present in this response.
- not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility.
- not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made.
- not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made.
- not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made.
- not scoredROR affiliation: Not checked or no result supplied; no credibility inference made.
- not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- supportingOpen access status: Normalized open-access status: open.
- not scoredPublication license: Not checked or no result supplied; no credibility inference made.
- not scoredPublication version: A publication version was supplied but is not scored.
- cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty.
Cite this work
BibTeX
@article{allodium:10.1021/acs.jmedchem.6c01913,
title = {From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.},
author = {Weber P and Smits R and Lim HD and Andaloussi M and Wijkmans J and de Boer B and Tran TD and Zarzycka B and Dekker ME and van der Meer T and Riemens R and Hauwert N and Wagner G and Vischer HF and Chapin MJ and Gomes P and Whitlock A and Wijtmans M and Leurs R and de Esch IJP},
year = {2026},
journal = {Journal of medicinal chemistry},
doi = {10.1021/acs.jmedchem.6c01913},
url = {https://doi.org/10.1021/acs.jmedchem.6c01913}
}RIS
TY - JOUR TI - From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis. AU - Weber P AU - Smits R AU - Lim HD AU - Andaloussi M AU - Wijkmans J AU - de Boer B AU - Tran TD AU - Zarzycka B AU - Dekker ME AU - van der Meer T AU - Riemens R AU - Hauwert N AU - Wagner G AU - Vischer HF AU - Chapin MJ AU - Gomes P AU - Whitlock A AU - Wijtmans M AU - Leurs R AU - de Esch IJP PY - 2026 JO - Journal of medicinal chemistry DO - 10.1021/acs.jmedchem.6c01913 UR - https://doi.org/10.1021/acs.jmedchem.6c01913 ER -
APA
P, W., R, S., HD, L., M, A., J, W., B, D. B., TD, T., B, Z., ME, D., T, V. D. M., R, R., N, H., G, W., HF, V., MJ, C., P, G., A, W., M, W., R, L., & IJP, D. E. (2026). From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis.. Journal of medicinal chemistry. https://doi.org/10.1021/acs.jmedchem.6c01913
Source records
- pubmed · retrieved 2026-09-27T08:38:37.826Z