Sulfoximines as Secondary Sulfonamide Isosteres: Paradoxical Impact on Solubility and Plasma Protein Binding

Sandra M. King, Ming Qian, Will Sii Hong Lau, Cristian Draghici, Tanzina Fazal, Pankaj Jain, Jeff Jin, Richard A. Lewis, Donglei Liu, Larry Miller, Wosenu Mergo, Jacob O’Leary, Keith Pfister, Maria Phan, Suzanne M. Skolnik, Xilin Zhou, Michael D. Shultz

Open source

DOI
10.1021/acs.jmedchem.6c01919
Published
2026-08-25
Container
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Open access
unknown

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BibTeX

@article{allodium:10.1021/acs.jmedchem.6c01919,
  title = {Sulfoximines
as Secondary Sulfonamide Isosteres: Paradoxical
Impact on Solubility and Plasma Protein Binding},
  author = {Sandra M. King and Ming Qian and Will Sii Hong Lau and Cristian Draghici and Tanzina Fazal and Pankaj Jain and Jeff Jin and Richard A. Lewis and Donglei Liu and Larry Miller and Wosenu Mergo and Jacob O’Leary and Keith Pfister and Maria Phan and Suzanne M. Skolnik and Xilin Zhou and Michael D. Shultz},
  year = {2026},
  journal = {Journal of Medicinal Chemistry},
  doi = {10.1021/acs.jmedchem.6c01919},
  url = {https://doi.org/10.1021/acs.jmedchem.6c01919}
}

RIS

TY  - JOUR
TI  - Sulfoximines
as Secondary Sulfonamide Isosteres: Paradoxical
Impact on Solubility and Plasma Protein Binding
AU  - Sandra M. King
AU  - Ming Qian
AU  - Will Sii Hong Lau
AU  - Cristian Draghici
AU  - Tanzina Fazal
AU  - Pankaj Jain
AU  - Jeff Jin
AU  - Richard A. Lewis
AU  - Donglei Liu
AU  - Larry Miller
AU  - Wosenu Mergo
AU  - Jacob O’Leary
AU  - Keith Pfister
AU  - Maria Phan
AU  - Suzanne M. Skolnik
AU  - Xilin Zhou
AU  - Michael D. Shultz
PY  - 2026
JO  - Journal of Medicinal Chemistry
DO  - 10.1021/acs.jmedchem.6c01919
UR  - https://doi.org/10.1021/acs.jmedchem.6c01919
ER  - 

APA

King, S. M., Qian, M., Lau, W. S. H., Draghici, C., Fazal, T., Jain, P., Jin, J., Lewis, R. A., Liu, D., Miller, L., Mergo, W., O’Leary, J., Pfister, K., Phan, M., Skolnik, S. M., Zhou, X., & Shultz, M. D. (2026). Sulfoximines as Secondary Sulfonamide Isosteres: Paradoxical Impact on Solubility and Plasma Protein Binding. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.6c01919

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