Conditional Mutant <i>MAPT</i> Overexpression in Neural Organoids Elicits Robust Tau Accumulation and Pathological Transcriptomic Responses

Andrew Kjar, Hyosung Kim, Madeline R. Spetz, Zev Jarrett, Melanie Fernandez, Jaime Wang, Maria L. Russotti, Caroline Bodnya, Daniel Chavarria, Timothy J. Hohman, Vivian Gama, Brad Grueter, Jonathan M. Brunger, Ethan S. Lippmann

Open source

DOI: 10.1021/acschemneuro.6c00376
Published: 2026-09-28
Container: ACS Chemical Neuroscience
Publisher: American Chemical Society (ACS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acschemneuro.6c00376,
  title = {Conditional
Mutant
                    <i>MAPT</i>
                    Overexpression
in Neural Organoids Elicits Robust Tau Accumulation and Pathological
Transcriptomic Responses},
  author = {Andrew Kjar and Hyosung Kim and Madeline R. Spetz and Zev Jarrett and Melanie Fernandez and Jaime Wang and Maria L. Russotti and Caroline Bodnya and Daniel Chavarria and Timothy J. Hohman and Vivian Gama and Brad Grueter and Jonathan M. Brunger and Ethan S. Lippmann},
  year = {2026},
  journal = {ACS Chemical Neuroscience},
  doi = {10.1021/acschemneuro.6c00376},
  url = {https://doi.org/10.1021/acschemneuro.6c00376}
}

RIS

TY  - JOUR
TI  - Conditional
Mutant
                    <i>MAPT</i>
                    Overexpression
in Neural Organoids Elicits Robust Tau Accumulation and Pathological
Transcriptomic Responses
AU  - Andrew Kjar
AU  - Hyosung Kim
AU  - Madeline R. Spetz
AU  - Zev Jarrett
AU  - Melanie Fernandez
AU  - Jaime Wang
AU  - Maria L. Russotti
AU  - Caroline Bodnya
AU  - Daniel Chavarria
AU  - Timothy J. Hohman
AU  - Vivian Gama
AU  - Brad Grueter
AU  - Jonathan M. Brunger
AU  - Ethan S. Lippmann
PY  - 2026
JO  - ACS Chemical Neuroscience
DO  - 10.1021/acschemneuro.6c00376
UR  - https://doi.org/10.1021/acschemneuro.6c00376
ER  -

APA

Kjar, A., Kim, H., Spetz, M. R., Jarrett, Z., Fernandez, M., Wang, J., Russotti, M. L., Bodnya, C., Chavarria, D., Hohman, T. J., Gama, V., Grueter, B., Brunger, J. M., & Lippmann, E. S. (2026). Conditional Mutant <i>MAPT</i> Overexpression in Neural Organoids Elicits Robust Tau Accumulation and Pathological Transcriptomic Responses. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.6c00376

Source records

crossref · retrieved 2026-11-07T06:42:03.703Z