Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation

Samantha A. Green, Russell T. Smith, Jessica M. Grandner, Mingshuo Zeng, Matthew Del Bel, Bing-Yan Zhu, Jun Liang, Marie-Gabrielle Braun, Jawahar Sudhamsu, Heidi Ackerly Wallweber, Gladys Boenig, Jeremy Murray, Xiaoli Shen, Renwei Zhang, Kwong Wah Lai, Anton Delwig, Maria Andrea Breboneria, Justin Ly, Anjani Ganti, Marika Nespi, Martin Weber, Rebecca Leahey, Flora I. Hinz, Bryan K. Chan

Open source

DOI: 10.1021/acsmedchemlett.5c00189
Published: 2025-05-20
Container: ACS Medicinal Chemistry Letters
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acsmedchemlett.5c00189,
  title = {Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation},
  author = {Samantha A. Green and Russell T. Smith and Jessica M. Grandner and Mingshuo Zeng and Matthew Del Bel and Bing-Yan Zhu and Jun Liang and Marie-Gabrielle Braun and Jawahar Sudhamsu and Heidi Ackerly Wallweber and Gladys Boenig and Jeremy Murray and Xiaoli Shen and Renwei Zhang and Kwong Wah Lai and Anton Delwig and Maria Andrea Breboneria and Justin Ly and Anjani Ganti and Marika Nespi and Martin Weber and Rebecca Leahey and Flora I. Hinz and Bryan K. Chan},
  year = {2025},
  journal = {ACS Medicinal Chemistry Letters},
  doi = {10.1021/acsmedchemlett.5c00189},
  url = {https://doi.org/10.1021/acsmedchemlett.5c00189}
}

RIS

TY  - JOUR
TI  - Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation
AU  - Samantha A. Green
AU  - Russell T. Smith
AU  - Jessica M. Grandner
AU  - Mingshuo Zeng
AU  - Matthew Del Bel
AU  - Bing-Yan Zhu
AU  - Jun Liang
AU  - Marie-Gabrielle Braun
AU  - Jawahar Sudhamsu
AU  - Heidi Ackerly Wallweber
AU  - Gladys Boenig
AU  - Jeremy Murray
AU  - Xiaoli Shen
AU  - Renwei Zhang
AU  - Kwong Wah Lai
AU  - Anton Delwig
AU  - Maria Andrea Breboneria
AU  - Justin Ly
AU  - Anjani Ganti
AU  - Marika Nespi
AU  - Martin Weber
AU  - Rebecca Leahey
AU  - Flora I. Hinz
AU  - Bryan K. Chan
PY  - 2025
JO  - ACS Medicinal Chemistry Letters
DO  - 10.1021/acsmedchemlett.5c00189
UR  - https://doi.org/10.1021/acsmedchemlett.5c00189
ER  -

APA

Green, S. A., Smith, R. T., Grandner, J. M., Zeng, M., Bel, M. D., Zhu, B., Liang, J., Braun, M., Sudhamsu, J., Wallweber, H. A., Boenig, G., Murray, J., Shen, X., Zhang, R., Lai, K. W., Delwig, A., Breboneria, M. A., Ly, J., Ganti, A., Nespi, M., Weber, M., Leahey, R., Hinz, F. I., & Chan, B. K. (2025). Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.5c00189

Source records

crossref · retrieved 2026-09-26T07:30:22.983Z