Optimization and <i>In Vivo</i> Characterization of a Series of Cbl-b Inactive-State Inhibitors

Michael J. Lambrecht, Jun Liang, Peter Man-Un Ung, Malcolm P. Huestis, Bing-Yan Zhu, Lisa M. Barton, Georgette M. Castanedo, Jason R. Zbieg, Robin Larouche-Gauthier, Araz Jakalian, Jean-Philippe Leclerc, Arun Yadav, Pouyan Haghshenas, Samuel Aubert-Nicol, Hossein Ismaili, Liang Zhao, Mélissa Leblanc, Jian Wang, Shouliang Wang, Qiuyue Wang, Thomas Garner, Sophia Tan, Madeleine Prangley, Fabio Broccatelli, Jodie Pang, Jeremy Murray, Christine Yu, Peter Hsu, Sascha Rutz, Satoko Kakiuchi-Kiyota, Isabel Ishizuka, Dennis H. Leung, Ponien Kou, Linda Bao, Xiaojing Wang

Open source

DOI: 10.1021/acsmedchemlett.6c00103
Published: 2026-05-14
Container: ACS Medicinal Chemistry Letters
Publisher: American Chemical Society (ACS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acsmedchemlett.6c00103,
  title = {Optimization and
                    <i>In Vivo</i>
                    Characterization of a Series of Cbl-b Inactive-State Inhibitors},
  author = {Michael J. Lambrecht and Jun Liang and Peter Man-Un Ung and Malcolm P. Huestis and Bing-Yan Zhu and Lisa M. Barton and Georgette M. Castanedo and Jason R. Zbieg and Robin Larouche-Gauthier and Araz Jakalian and Jean-Philippe Leclerc and Arun Yadav and Pouyan Haghshenas and Samuel Aubert-Nicol and Hossein Ismaili and Liang Zhao and Mélissa Leblanc and Jian Wang and Shouliang Wang and Qiuyue Wang and Thomas Garner and Sophia Tan and Madeleine Prangley and Fabio Broccatelli and Jodie Pang and Jeremy Murray and Christine Yu and Peter Hsu and Sascha Rutz and Satoko Kakiuchi-Kiyota and Isabel Ishizuka and Dennis H. Leung and Ponien Kou and Linda Bao and Xiaojing Wang},
  year = {2026},
  journal = {ACS Medicinal Chemistry Letters},
  doi = {10.1021/acsmedchemlett.6c00103},
  url = {https://doi.org/10.1021/acsmedchemlett.6c00103}
}

RIS

TY  - JOUR
TI  - Optimization and
                    <i>In Vivo</i>
                    Characterization of a Series of Cbl-b Inactive-State Inhibitors
AU  - Michael J. Lambrecht
AU  - Jun Liang
AU  - Peter Man-Un Ung
AU  - Malcolm P. Huestis
AU  - Bing-Yan Zhu
AU  - Lisa M. Barton
AU  - Georgette M. Castanedo
AU  - Jason R. Zbieg
AU  - Robin Larouche-Gauthier
AU  - Araz Jakalian
AU  - Jean-Philippe Leclerc
AU  - Arun Yadav
AU  - Pouyan Haghshenas
AU  - Samuel Aubert-Nicol
AU  - Hossein Ismaili
AU  - Liang Zhao
AU  - Mélissa Leblanc
AU  - Jian Wang
AU  - Shouliang Wang
AU  - Qiuyue Wang
AU  - Thomas Garner
AU  - Sophia Tan
AU  - Madeleine Prangley
AU  - Fabio Broccatelli
AU  - Jodie Pang
AU  - Jeremy Murray
AU  - Christine Yu
AU  - Peter Hsu
AU  - Sascha Rutz
AU  - Satoko Kakiuchi-Kiyota
AU  - Isabel Ishizuka
AU  - Dennis H. Leung
AU  - Ponien Kou
AU  - Linda Bao
AU  - Xiaojing Wang
PY  - 2026
JO  - ACS Medicinal Chemistry Letters
DO  - 10.1021/acsmedchemlett.6c00103
UR  - https://doi.org/10.1021/acsmedchemlett.6c00103
ER  -

APA

Lambrecht, M. J., Liang, J., Ung, P. M., Huestis, M. P., Zhu, B., Barton, L. M., Castanedo, G. M., Zbieg, J. R., Larouche-Gauthier, R., Jakalian, A., Leclerc, J., Yadav, A., Haghshenas, P., Aubert-Nicol, S., Ismaili, H., Zhao, L., Leblanc, M., Wang, J., Wang, S., Wang, Q., Garner, T., Tan, S., Prangley, M., Broccatelli, F., Pang, J., Murray, J., Yu, C., Hsu, P., Rutz, S., Kakiuchi-Kiyota, S., Ishizuka, I., Leung, D. H., Kou, P., Bao, L., & Wang, X. (2026). Optimization and <i>In Vivo</i> Characterization of a Series of Cbl-b Inactive-State Inhibitors. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.6c00103

Source records

crossref · retrieved 2026-09-27T16:01:04.730Z