Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal KV7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity

Shaoyi Sun, Qi Jia, Girish Bankar, Kristen N. Burford, Jessica Christabel, Helen A. Clement, Gina de Boer, Zirui Feng, Chido M. Hambira, Stephen K. Jackson, Kuldip Khakh, Rainbow Kwan, Stephanie Lee, Jenny Li, Andrea Lindgren, Janette Mezeyova, Juliette Sabbatini, Art Urrutia, Paul Charifson, Michael P. Clark, Steven S. Wesolowski, James P. Johnson, James R. Empfield, Christoph M. Dehnhardt, Richard Dean

Open source

DOI: 10.1021/acsmedchemlett.6c00360
Published: 2026-08-22
Container: ACS Medicinal Chemistry Letters
Publisher: American Chemical Society (ACS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1021/acsmedchemlett.6c00360,
  title = {Discovery
of Novel Bicyclic Pyrazole Amides as Potent
Neuronal KV7 Potassium Channel Openers with Strong Preclinical
Antiseizure Activity},
  author = {Shaoyi Sun and Qi Jia and Girish Bankar and Kristen N. Burford and Jessica Christabel and Helen A. Clement and Gina de Boer and Zirui Feng and Chido M. Hambira and Stephen K. Jackson and Kuldip Khakh and Rainbow Kwan and Stephanie Lee and Jenny Li and Andrea Lindgren and Janette Mezeyova and Juliette Sabbatini and Art Urrutia and Paul Charifson and Michael P. Clark and Steven S. Wesolowski and James P. Johnson and James R. Empfield and Christoph M. Dehnhardt and Richard Dean},
  year = {2026},
  journal = {ACS Medicinal Chemistry
Letters},
  doi = {10.1021/acsmedchemlett.6c00360},
  url = {https://doi.org/10.1021/acsmedchemlett.6c00360}
}

RIS

TY  - JOUR
TI  - Discovery
of Novel Bicyclic Pyrazole Amides as Potent
Neuronal KV7 Potassium Channel Openers with Strong Preclinical
Antiseizure Activity
AU  - Shaoyi Sun
AU  - Qi Jia
AU  - Girish Bankar
AU  - Kristen N. Burford
AU  - Jessica Christabel
AU  - Helen A. Clement
AU  - Gina de Boer
AU  - Zirui Feng
AU  - Chido M. Hambira
AU  - Stephen K. Jackson
AU  - Kuldip Khakh
AU  - Rainbow Kwan
AU  - Stephanie Lee
AU  - Jenny Li
AU  - Andrea Lindgren
AU  - Janette Mezeyova
AU  - Juliette Sabbatini
AU  - Art Urrutia
AU  - Paul Charifson
AU  - Michael P. Clark
AU  - Steven S. Wesolowski
AU  - James P. Johnson
AU  - James R. Empfield
AU  - Christoph M. Dehnhardt
AU  - Richard Dean
PY  - 2026
JO  - ACS Medicinal Chemistry
Letters
DO  - 10.1021/acsmedchemlett.6c00360
UR  - https://doi.org/10.1021/acsmedchemlett.6c00360
ER  -

APA

Sun, S., Jia, Q., Bankar, G., Burford, K. N., Christabel, J., Clement, H. A., Boer, G. D., Feng, Z., Hambira, C. M., Jackson, S. K., Khakh, K., Kwan, R., Lee, S., Li, J., Lindgren, A., Mezeyova, J., Sabbatini, J., Urrutia, A., Charifson, P., Clark, M. P., Wesolowski, S. S., Johnson, J. P., Empfield, J. R., Dehnhardt, C. M., & Dean, R. (2026). Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal KV7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/acsmedchemlett.6c00360

Source records

crossref · retrieved 2026-09-27T00:06:21.400Z