The 5'-Isobutyryl Ester Prodrug of 4'-Thiouridine Inhibits SARS-CoV‑2 Replication in Culture and in a Syrian Hamster Infection Model.

Chen Z, Amblard F, Kasthuri M, Tber Z, LeCher JC, Tao S, De R, Marko I, Bassit L, Zandi K, McBrayer T, Hurwitz SH, Weynand B, Abdelnabi R, Neyts J, Bhatt S, Boras B, Cardin RD, Zhu Y, Kapoor M, Eng H, Kalgutkar AS, Greenfield SR, Thakare R, King-Ahmad A, Patel NC, Johnson KA, Hepworth D, Fensome A, Schinazi RF

Open source

DOI: 10.1021/acsomega.6c00102
Published: 2026 Jul 28
Container: ACS omega
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1021/acsomega.6c00102,
  title = {The 5'-Isobutyryl Ester Prodrug of 4'-Thiouridine Inhibits SARS-CoV‑2 Replication in Culture and in a Syrian Hamster Infection Model.},
  author = {Chen Z and Amblard F and Kasthuri M and Tber Z and LeCher JC and Tao S and De R and Marko I and Bassit L and Zandi K and McBrayer T and Hurwitz SH and Weynand B and Abdelnabi R and Neyts J and Bhatt S and Boras B and Cardin RD and Zhu Y and Kapoor M and Eng H and Kalgutkar AS and Greenfield SR and Thakare R and King-Ahmad A and Patel NC and Johnson KA and Hepworth D and Fensome A and Schinazi RF},
  year = {2026},
  journal = {ACS omega},
  doi = {10.1021/acsomega.6c00102},
  url = {https://doi.org/10.1021/acsomega.6c00102}
}

RIS

TY  - JOUR
TI  - The 5'-Isobutyryl Ester Prodrug of 4'-Thiouridine Inhibits SARS-CoV‑2 Replication in Culture and in a Syrian Hamster Infection Model.
AU  - Chen Z
AU  - Amblard F
AU  - Kasthuri M
AU  - Tber Z
AU  - LeCher JC
AU  - Tao S
AU  - De R
AU  - Marko I
AU  - Bassit L
AU  - Zandi K
AU  - McBrayer T
AU  - Hurwitz SH
AU  - Weynand B
AU  - Abdelnabi R
AU  - Neyts J
AU  - Bhatt S
AU  - Boras B
AU  - Cardin RD
AU  - Zhu Y
AU  - Kapoor M
AU  - Eng H
AU  - Kalgutkar AS
AU  - Greenfield SR
AU  - Thakare R
AU  - King-Ahmad A
AU  - Patel NC
AU  - Johnson KA
AU  - Hepworth D
AU  - Fensome A
AU  - Schinazi RF
PY  - 2026
JO  - ACS omega
DO  - 10.1021/acsomega.6c00102
UR  - https://doi.org/10.1021/acsomega.6c00102
ER  -

APA

Z, C., F, A., M, K., Z, T., JC, L., S, T., R, D., I, M., L, B., K, Z., T, M., SH, H., B, W., R, A., J, N., S, B., B, B., RD, C., Y, Z., M, K., H, E., AS, K., SR, G., R, T., A, K., NC, P., KA, J., D, H., A, F., & RF, S. (2026). The 5'-Isobutyryl Ester Prodrug of 4'-Thiouridine Inhibits SARS-CoV‑2 Replication in Culture and in a Syrian Hamster Infection Model.. ACS omega. https://doi.org/10.1021/acsomega.6c00102

Source records

pubmed · retrieved 2026-09-26T17:13:11.584Z