1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
- DOI
- 10.1021/jm3000449
- Published
- 2012 Mar 22
- Container
- Journal of medicinal chemistry
- Publisher
- Not recorded
- Open access
- unknown
Credibility signals
limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.
Show all credibility signals
- cautionDOI registered: No matching Crossref record was present in this response.
- cautionDOI resolves: No matching Crossref record was present in this response.
- not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility.
- not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made.
- not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made.
- not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made.
- not scoredROR affiliation: Not checked or no result supplied; no credibility inference made.
- not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredOpen access status: Not checked or no result supplied; no credibility inference made.
- not scoredPublication license: Not checked or no result supplied; no credibility inference made.
- not scoredPublication version: A publication version was supplied but is not scored.
- cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty.
Cite this work
BibTeX
@article{allodium:10.1021/jm3000449,
title = {1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.},
author = {Ramnauth J and Renton P and Dove P and Annedi SC and Speed J and Silverman S and Mladenova G and Maddaford SP and Zinghini S and Rakhit S and Andrews J and Lee DK and Zhang D and Porreca F},
year = {2012},
journal = {Journal of medicinal chemistry},
doi = {10.1021/jm3000449},
url = {https://doi.org/10.1021/jm3000449}
}RIS
TY - JOUR TI - 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate. AU - Ramnauth J AU - Renton P AU - Dove P AU - Annedi SC AU - Speed J AU - Silverman S AU - Mladenova G AU - Maddaford SP AU - Zinghini S AU - Rakhit S AU - Andrews J AU - Lee DK AU - Zhang D AU - Porreca F PY - 2012 JO - Journal of medicinal chemistry DO - 10.1021/jm3000449 UR - https://doi.org/10.1021/jm3000449 ER -
APA
J, R., P, R., P, D., SC, A., J, S., S, S., G, M., SP, M., S, Z., S, R., J, A., DK, L., D, Z., & F, P. (2012). 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.. Journal of medicinal chemistry. https://doi.org/10.1021/jm3000449
Source records
- pubmed · retrieved 2026-09-26T05:37:40.935Z