Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT Jr, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido MJ, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O'Donnell CJ, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Bonuccelli U, Winslow AR, Daniele A, Wu CK, GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Combarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues JF, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze JF, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang LS, Lambert JC, Seshadri S, Williams J, Schellenberg GD

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DOI
10.1038/ng.3916
Published
2017 Sep
Container
Nature genetics
Publisher
Not recorded
Open access
yes

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@article{allodium:10.1038/ng.3916,
  title = {Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.},
  author = {Sims R and van der Lee SJ and Naj AC and Bellenguez C and Badarinarayan N and Jakobsdottir J and Kunkle BW and Boland A and Raybould R and Bis JC and Martin ER and Grenier-Boley B and Heilmann-Heimbach S and Chouraki V and Kuzma AB and Sleegers K and Vronskaya M and Ruiz A and Graham RR and Olaso R and Hoffmann P and Grove ML and Vardarajan BN and Hiltunen M and Nöthen MM and White CC and Hamilton-Nelson KL and Epelbaum J and Maier W and Choi SH and Beecham GW and Dulary C and Herms S and Smith AV and Funk CC and Derbois C and Forstner AJ and Ahmad S and Li H and Bacq D and Harold D and Satizabal CL and Valladares O and Squassina A and Thomas R and Brody JA and Qu L and Sánchez-Juan P and Morgan T and Wolters FJ and Zhao Y and Garcia FS and Denning N and Fornage M and Malamon J and Naranjo MCD and Majounie E and Mosley TH and Dombroski B and Wallon D and Lupton MK and Dupuis J and Whitehead P and Fratiglioni L and Medway C and Jian X and Mukherjee S and Keller L and Brown K and Lin H and Cantwell LB and Panza F and McGuinness B and Moreno-Grau S and Burgess JD and Solfrizzi V and Proitsi P and Adams HH and Allen M and Seripa D and Pastor P and Cupples LA and Price ND and Hannequin D and Frank-García A and Levy D and Chakrabarty P and Caffarra P and Giegling I and Beiser AS and Giedraitis V and Hampel H and Garcia ME and Wang X and Lannfelt L and Mecocci P and Eiriksdottir G and Crane PK and Pasquier F and Boccardi V and Henández I and Barber RC and Scherer M and Tarraga L and Adams PM and Leber M and Chen Y and Albert MS and Riedel-Heller S and Emilsson V and Beekly D and Braae A and Schmidt R and Blacker D and Masullo C and Schmidt H and Doody RS and Spalletta G and Longstreth WT Jr and Fairchild TJ and Bossù P and Lopez OL and Frosch MP and Sacchinelli E and Ghetti B and Yang Q and Huebinger RM and Jessen F and Li S and Kamboh MI and Morris J and Sotolongo-Grau O and Katz MJ and Corcoran C and Dunstan M and Braddel A and Thomas C and Meggy A and Marshall R and Gerrish A and Chapman J and Aguilar M and Taylor S and Hill M and Fairén MD and Hodges A and Vellas B and Soininen H and Kloszewska I and Daniilidou M and Uphill J and Patel Y and Hughes JT and Lord J and Turton J and Hartmann AM and Cecchetti R and Fenoglio C and Serpente M and Arcaro M and Caltagirone C and Orfei MD and Ciaramella A and Pichler S and Mayhaus M and Gu W and Lleó A and Fortea J and Blesa R and Barber IS and Brookes K and Cupidi C and Maletta RG and Carrell D and Sorbi S and Moebus S and Urbano M and Pilotto A and Kornhuber J and Bosco P and Todd S and Craig D and Johnston J and Gill M and Lawlor B and Lynch A and Fox NC and Hardy J and ARUK Consortium and Albin RL and Apostolova LG and Arnold SE and Asthana S and Atwood CS and Baldwin CT and Barnes LL and Barral S and Beach TG and Becker JT and Bigio EH and Bird TD and Boeve BF and Bowen JD and Boxer A and Burke JR and Burns JM and Buxbaum JD and Cairns NJ and Cao C and Carlson CS and Carlsson CM and Carney RM and Carrasquillo MM and Carroll SL and Diaz CC and Chui HC and Clark DG and Cribbs DH and Crocco EA and DeCarli C and Dick M and Duara R and Evans DA and Faber KM and Fallon KB and Fardo DW and Farlow MR and Ferris S and Foroud TM and Galasko DR and Gearing M and Geschwind DH and Gilbert JR and Graff-Radford NR and Green RC and Growdon JH and Hamilton RL and Harrell LE and Honig LS and Huentelman MJ and Hulette CM and Hyman BT and Jarvik GP and Abner E and Jin LW and Jun G and Karydas A and Kaye JA and Kim R and Kowall NW and Kramer JH and LaFerla FM and Lah JJ and Leverenz JB and Levey AI and Li G and Lieberman AP and Lunetta KL and Lyketsos CG and Marson DC and Martiniuk F and Mash DC and Masliah E and McCormick WC and McCurry SM and McDavid AN and McKee AC and Mesulam M and Miller BL and Miller CA and Miller JW and Morris JC and Murrell JR and Myers AJ and O'Bryant S and Olichney JM and Pankratz VS and Parisi JE and Paulson HL and Perry W and Peskind E and Pierce A and Poon WW and Potter H and Quinn JF and Raj A and Raskind M and Reisberg B and Reitz C and Ringman JM and Roberson ED and Rogaeva E and Rosen HJ and Rosenberg RN and Sager MA and Saykin AJ and Schneider JA and Schneider LS and Seeley WW and Smith AG and Sonnen JA and Spina S and Stern RA and Swerdlow RH and Tanzi RE and Thornton-Wells TA and Trojanowski JQ and Troncoso JC and Van Deerlin VM and Van Eldik LJ and Vinters HV and Vonsattel JP and Weintraub S and Welsh-Bohmer KA and Wilhelmsen KC and Williamson J and Wingo TS and Woltjer RL and Wright CB and Yu CE and Yu L and Garzia F and Golamaully F and Septier G and Engelborghs S and Vandenberghe R and De Deyn PP and Fernadez CM and Benito YA and Thonberg H and Forsell C and Lilius L and Kinhult-Stählbom A and Kilander L and Brundin R and Concari L and Helisalmi S and Koivisto AM and Haapasalo A and Dermecourt V and Fievet N and Hanon O and Dufouil C and Brice A and Ritchie K and Dubois B and Himali JJ and Keene CD and Tschanz J and Fitzpatrick AL and Kukull WA and Norton M and Aspelund T and Larson EB and Munger R and Rotter JI and Lipton RB and Bullido MJ and Hofman A and Montine TJ and Coto E and Boerwinkle E and Petersen RC and Alvarez V and Rivadeneira F and Reiman EM and Gallo M and O'Donnell CJ and Reisch JS and Bruni AC and Royall DR and Dichgans M and Sano M and Galimberti D and St George-Hyslop P and Scarpini E and Tsuang DW and Mancuso M and Bonuccelli U and Winslow AR and Daniele A and Wu CK and GERAD/PERADES, CHARGE, ADGC, EADI and Peters O and Nacmias B and Riemenschneider M and Heun R and Brayne C and Rubinsztein DC and Bras J and Guerreiro R and Al-Chalabi A and Shaw CE and Collinge J and Mann D and Tsolaki M and Clarimón J and Sussams R and Lovestone S and O'Donovan MC and Owen MJ and Behrens TW and Mead S and Goate AM and Uitterlinden AG and Holmes C and Cruchaga C and Ingelsson M and Bennett DA and Powell J and Golde TE and Graff C and De Jager PL and Morgan K and Ertekin-Taner N and Combarros O and Psaty BM and Passmore P and Younkin SG and Berr C and Gudnason V and Rujescu D and Dickson DW and Dartigues JF and DeStefano AL and Ortega-Cubero S and Hakonarson H and Campion D and Boada M and Kauwe JK and Farrer LA and Van Broeckhoven C and Ikram MA and Jones L and Haines JL and Tzourio C and Launer LJ and Escott-Price V and Mayeux R and Deleuze JF and Amin N and Holmans PA and Pericak-Vance MA and Amouyel P and van Duijn CM and Ramirez A and Wang LS and Lambert JC and Seshadri S and Williams J and Schellenberg GD},
  year = {2017},
  journal = {Nature genetics},
  doi = {10.1038/ng.3916},
  url = {https://doi.org/10.1038/ng.3916}
}

RIS

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TI  - Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
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AU  - Amin N
AU  - Holmans PA
AU  - Pericak-Vance MA
AU  - Amouyel P
AU  - van Duijn CM
AU  - Ramirez A
AU  - Wang LS
AU  - Lambert JC
AU  - Seshadri S
AU  - Williams J
AU  - Schellenberg GD
PY  - 2017
JO  - Nature genetics
DO  - 10.1038/ng.3916
UR  - https://doi.org/10.1038/ng.3916
ER  -

APA

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