Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.

Rai C, Ruan H, Li X, Li W, Jeong HH, Song C, Liu P, Chang Y, Fang H, Kumar S U, Sun Y, You MJ, Guan D, Liu Z, Han L, Hou X, Sun Z

Open source

DOI: 10.1038/s41392-026-02698-1
Published: 2026 Jun 5
Container: Signal transduction and targeted therapy
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41392-026-02698-1,
  title = {Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.},
  author = {Rai C and Ruan H and Li X and Li W and Jeong HH and Song C and Liu P and Chang Y and Fang H and Kumar S U and Sun Y and You MJ and Guan D and Liu Z and Han L and Hou X and Sun Z},
  year = {2026},
  journal = {Signal transduction and targeted therapy},
  doi = {10.1038/s41392-026-02698-1},
  url = {https://doi.org/10.1038/s41392-026-02698-1}
}

RIS

TY  - JOUR
TI  - Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.
AU  - Rai C
AU  - Ruan H
AU  - Li X
AU  - Li W
AU  - Jeong HH
AU  - Song C
AU  - Liu P
AU  - Chang Y
AU  - Fang H
AU  - Kumar S U
AU  - Sun Y
AU  - You MJ
AU  - Guan D
AU  - Liu Z
AU  - Han L
AU  - Hou X
AU  - Sun Z
PY  - 2026
JO  - Signal transduction and targeted therapy
DO  - 10.1038/s41392-026-02698-1
UR  - https://doi.org/10.1038/s41392-026-02698-1
ER  -

APA

C, R., H, R., X, L., W, L., HH, J., C, S., P, L., Y, C., H, F., U, K. S., Y, S., MJ, Y., D, G., Z, L., L, H., X, H., & Z, S. (2026). Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.. Signal transduction and targeted therapy. https://doi.org/10.1038/s41392-026-02698-1

Source records

pubmed · retrieved 2026-09-26T01:23:43.211Z