Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures

Jinsen Lu, Srinivasa Rao Rao, Helen Knowles, Haoqun Zhan, Beatriz Gamez, Mingyu Qin, Eleanor Platt, Lucy R. Frost, Tiffany-Jayne Allen, Gayle Marshall, Kilian V. M. Huber, Ludwig G. Bauer, Iolanda Vendrell, Darragh P. O’Brien, Benedikt Kessler, Anne Horne, Ian R. Reid, Chas Bountra, James L. Kirkland, Sundeep Khosla, Frank H. Ebetino, Emilio Roldan, R. Graham G. Russell, James R. Edwards

Open source

DOI: 10.1038/s41392-026-02799-x
Published: 2026-07-15
Container: Signal Transduction and Targeted Therapy
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41392-026-02799-x,
  title = {Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures},
  author = {Jinsen Lu and Srinivasa Rao Rao and Helen Knowles and Haoqun Zhan and Beatriz Gamez and Mingyu Qin and Eleanor Platt and Lucy R. Frost and Tiffany-Jayne Allen and Gayle Marshall and Kilian V. M. Huber and Ludwig G. Bauer and Iolanda Vendrell and Darragh P. O’Brien and Benedikt Kessler and Anne Horne and Ian R. Reid and Chas Bountra and James L. Kirkland and Sundeep Khosla and Frank H. Ebetino and Emilio Roldan and R. Graham G. Russell and James R. Edwards},
  year = {2026},
  journal = {Signal Transduction and Targeted Therapy},
  doi = {10.1038/s41392-026-02799-x},
  url = {https://doi.org/10.1038/s41392-026-02799-x}
}

RIS

TY  - JOUR
TI  - Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures
AU  - Jinsen Lu
AU  - Srinivasa Rao Rao
AU  - Helen Knowles
AU  - Haoqun Zhan
AU  - Beatriz Gamez
AU  - Mingyu Qin
AU  - Eleanor Platt
AU  - Lucy R. Frost
AU  - Tiffany-Jayne Allen
AU  - Gayle Marshall
AU  - Kilian V. M. Huber
AU  - Ludwig G. Bauer
AU  - Iolanda Vendrell
AU  - Darragh P. O’Brien
AU  - Benedikt Kessler
AU  - Anne Horne
AU  - Ian R. Reid
AU  - Chas Bountra
AU  - James L. Kirkland
AU  - Sundeep Khosla
AU  - Frank H. Ebetino
AU  - Emilio Roldan
AU  - R. Graham G. Russell
AU  - James R. Edwards
PY  - 2026
JO  - Signal Transduction and Targeted Therapy
DO  - 10.1038/s41392-026-02799-x
UR  - https://doi.org/10.1038/s41392-026-02799-x
ER  -

APA

Lu, J., Rao, S. R., Knowles, H., Zhan, H., Gamez, B., Qin, M., Platt, E., Frost, L. R., Allen, T., Marshall, G., Huber, K. V. M., Bauer, L. G., Vendrell, I., O’Brien, D. P., Kessler, B., Horne, A., Reid, I. R., Bountra, C., Kirkland, J. L., Khosla, S., Ebetino, F. H., Roldan, E., Russell, R. G. G., & Edwards, J. R. (2026). Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-026-02799-x

Source records

crossref · retrieved 2026-09-26T14:30:44.359Z