Multi-omics analyses identify EZH2 as a central driver in rhabdomyosarcoma radioresistance and highlight Tazemetostat as an effective radiosensitizer in vitro and in vivo

Matteo Cassandri, Antonella Porrazzo, Simona Camero, Silvia Pomella, Valeria Manzi, Francesca Vulcano, Luisa Milazzo, Francesca Pedini, Deborah Pajalunga, Andrea Casagrande, Giada Mele, Valentina Lulli, Enrico Romano, Michele Signore, Massimo Spada, Maria Teresa D’Urso, Silvia Codenotti, Alessandro Fanzani, Annunziata Mauro, Giovanna Marchese, Simone Sidoli, Giovanni Luca Gravina, Giovanni Barillari, Franco Locatelli, Francesca Megiorni, Rossella Rota, Francesco Marampon

Open source

DOI: 10.1038/s41419-026-08938-0
Published: 2026-06-01
Container: Cell Death & Disease
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41419-026-08938-0,
  title = {Multi-omics analyses identify EZH2 as a central driver in rhabdomyosarcoma radioresistance and highlight Tazemetostat as an effective radiosensitizer in vitro and in vivo},
  author = {Matteo Cassandri and Antonella Porrazzo and Simona Camero and Silvia Pomella and Valeria Manzi and Francesca Vulcano and Luisa Milazzo and Francesca Pedini and Deborah Pajalunga and Andrea Casagrande and Giada Mele and Valentina Lulli and Enrico Romano and Michele Signore and Massimo Spada and Maria Teresa D’Urso and Silvia Codenotti and Alessandro Fanzani and Annunziata Mauro and Giovanna Marchese and Simone Sidoli and Giovanni Luca Gravina and Giovanni Barillari and Franco Locatelli and Francesca Megiorni and Rossella Rota and Francesco Marampon},
  year = {2026},
  journal = {Cell Death \&amp; Disease},
  doi = {10.1038/s41419-026-08938-0},
  url = {https://doi.org/10.1038/s41419-026-08938-0}
}

RIS

TY  - JOUR
TI  - Multi-omics analyses identify EZH2 as a central driver in rhabdomyosarcoma radioresistance and highlight Tazemetostat as an effective radiosensitizer in vitro and in vivo
AU  - Matteo Cassandri
AU  - Antonella Porrazzo
AU  - Simona Camero
AU  - Silvia Pomella
AU  - Valeria Manzi
AU  - Francesca Vulcano
AU  - Luisa Milazzo
AU  - Francesca Pedini
AU  - Deborah Pajalunga
AU  - Andrea Casagrande
AU  - Giada Mele
AU  - Valentina Lulli
AU  - Enrico Romano
AU  - Michele Signore
AU  - Massimo Spada
AU  - Maria Teresa D’Urso
AU  - Silvia Codenotti
AU  - Alessandro Fanzani
AU  - Annunziata Mauro
AU  - Giovanna Marchese
AU  - Simone Sidoli
AU  - Giovanni Luca Gravina
AU  - Giovanni Barillari
AU  - Franco Locatelli
AU  - Francesca Megiorni
AU  - Rossella Rota
AU  - Francesco Marampon
PY  - 2026
JO  - Cell Death &amp; Disease
DO  - 10.1038/s41419-026-08938-0
UR  - https://doi.org/10.1038/s41419-026-08938-0
ER  -

APA

Cassandri, M., Porrazzo, A., Camero, S., Pomella, S., Manzi, V., Vulcano, F., Milazzo, L., Pedini, F., Pajalunga, D., Casagrande, A., Mele, G., Lulli, V., Romano, E., Signore, M., Spada, M., D’Urso, M. T., Codenotti, S., Fanzani, A., Mauro, A., Marchese, G., Sidoli, S., Gravina, G. L., Barillari, G., Locatelli, F., Megiorni, F., Rota, R., & Marampon, F. (2026). Multi-omics analyses identify EZH2 as a central driver in rhabdomyosarcoma radioresistance and highlight Tazemetostat as an effective radiosensitizer in vitro and in vivo. Cell Death & Disease. https://doi.org/10.1038/s41419-026-08938-0

Source records

crossref · retrieved 2026-09-26T01:48:21.747Z