The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.

Guo L, Huang B, Yu H, Xu Y, Wei L, Zheng J, Li Y, Wu D, Zhao P, Wu C, Tan W, Jia Y

Open source

DOI: 10.1038/s41421-026-00918-0
Published: 2026 Sep 15
Container: Cell discovery
Publisher: Not recorded
Open access: yes

Credibility signals

uncertain Score 53/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
supportingDirectory of Open Access Journals: A matching record was returned by DOAJ. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41421-026-00918-0,
  title = {The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.},
  author = {Guo L and Huang B and Yu H and Xu Y and Wei L and Zheng J and Li Y and Wu D and Zhao P and Wu C and Tan W and Jia Y},
  year = {2026},
  journal = {Cell discovery},
  doi = {10.1038/s41421-026-00918-0},
  url = {https://doi.org/10.1038/s41421-026-00918-0}
}

RIS

TY  - JOUR
TI  - The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.
AU  - Guo L
AU  - Huang B
AU  - Yu H
AU  - Xu Y
AU  - Wei L
AU  - Zheng J
AU  - Li Y
AU  - Wu D
AU  - Zhao P
AU  - Wu C
AU  - Tan W
AU  - Jia Y
PY  - 2026
JO  - Cell discovery
DO  - 10.1038/s41421-026-00918-0
UR  - https://doi.org/10.1038/s41421-026-00918-0
ER  -

APA

L, G., B, H., H, Y., Y, X., L, W., J, Z., Y, L., D, W., P, Z., C, W., W, T., & Y, J. (2026). The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis.. Cell discovery. https://doi.org/10.1038/s41421-026-00918-0

Source records

pubmed · retrieved 2026-09-26T01:02:03.312Z
europe-pmc · retrieved 2026-09-26T01:02:03.322Z
doaj · retrieved 2026-09-26T01:02:03.346Z