DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.

Schröder M, Renatus M, Liang X, Meili F, Zoller T, Ferrand S, Gauter F, Li X, Sigoillot F, Gleim S, Stachyra TM, Thomas JR, Begue D, Khoshouei M, Lefeuvre P, Andraos-Rey R, Chung B, Ma R, Pinch B, Hofmann A, Schirle M, Schmiedeberg N, Imbach P, Gorses D, Calkins K, Bauer-Probst B, Maschlej M, Niederst M, Maher R, Henault M, Alford J, Ahrne E, Tordella L, Hollingworth G, Thomä NH, Vulpetti A, Radimerski T, Holzer P, Carbonneau S, Thoma CR

Open source

DOI: 10.1038/s41467-023-44237-4
Published: 2024 Jan 4
Container: Nature communications
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41467-023-44237-4,
  title = {DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.},
  author = {Schröder M and Renatus M and Liang X and Meili F and Zoller T and Ferrand S and Gauter F and Li X and Sigoillot F and Gleim S and Stachyra TM and Thomas JR and Begue D and Khoshouei M and Lefeuvre P and Andraos-Rey R and Chung B and Ma R and Pinch B and Hofmann A and Schirle M and Schmiedeberg N and Imbach P and Gorses D and Calkins K and Bauer-Probst B and Maschlej M and Niederst M and Maher R and Henault M and Alford J and Ahrne E and Tordella L and Hollingworth G and Thomä NH and Vulpetti A and Radimerski T and Holzer P and Carbonneau S and Thoma CR},
  year = {2024},
  journal = {Nature communications},
  doi = {10.1038/s41467-023-44237-4},
  url = {https://doi.org/10.1038/s41467-023-44237-4}
}

RIS

TY  - JOUR
TI  - DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.
AU  - Schröder M
AU  - Renatus M
AU  - Liang X
AU  - Meili F
AU  - Zoller T
AU  - Ferrand S
AU  - Gauter F
AU  - Li X
AU  - Sigoillot F
AU  - Gleim S
AU  - Stachyra TM
AU  - Thomas JR
AU  - Begue D
AU  - Khoshouei M
AU  - Lefeuvre P
AU  - Andraos-Rey R
AU  - Chung B
AU  - Ma R
AU  - Pinch B
AU  - Hofmann A
AU  - Schirle M
AU  - Schmiedeberg N
AU  - Imbach P
AU  - Gorses D
AU  - Calkins K
AU  - Bauer-Probst B
AU  - Maschlej M
AU  - Niederst M
AU  - Maher R
AU  - Henault M
AU  - Alford J
AU  - Ahrne E
AU  - Tordella L
AU  - Hollingworth G
AU  - Thomä NH
AU  - Vulpetti A
AU  - Radimerski T
AU  - Holzer P
AU  - Carbonneau S
AU  - Thoma CR
PY  - 2024
JO  - Nature communications
DO  - 10.1038/s41467-023-44237-4
UR  - https://doi.org/10.1038/s41467-023-44237-4
ER  -

APA

M, S., M, R., X, L., F, M., T, Z., S, F., F, G., X, L., F, S., S, G., TM, S., JR, T., D, B., M, K., P, L., R, A., B, C., R, M., B, P., A, H., M, S., N, S., P, I., D, G., K, C., B, B., M, M., M, N., R, M., M, H., J, A., E, A., L, T., G, H., NH, T., A, V., T, R., P, H., S, C., & CR, T. (2024). DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance.. Nature communications. https://doi.org/10.1038/s41467-023-44237-4

Source records

pubmed · retrieved 2026-09-27T11:03:10.877Z