Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial

Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

Open source

DOI: 10.1038/s41467-025-61691-4
Published: 2025-07-21
Container: Nature Communications
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-025-61691-4,
  title = {Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial},
  author = {Dean A. Fennell and Kayleigh Hill and Min Zhang and Charlotte Poile and Sean Ewings and Essa Y. Baitei and Joanna Dzialo and Nada Nusrat and Jan Rogel and Daniel Faulkner and Christian Ottensmeier and Raffaele Califano and Gerard G. Hanna and Sarah Danson and Nicola Steele and Mavis Nye and Lucy Johnson and Kim Mallard and Joanne Lord and Calley Middleton and Peter Szlosarek and Sam Chan and Liz Darlison and Peter Wells-Jordan and Cathy Richards and James Harber and Aleksandra Bzura and Jake Spicer and Catrin Pritchard and Tamihiro Kamata and Jens C. Hahne and Maymun Jama and Edward J. Hollox and Jason F. Lester and Jin-Li Luo and Zisen Zhou and Hongji Yang and Huiyu Zhou and Astero Klampatsa and Gareth O. Griffiths},
  year = {2025},
  journal = {Nature Communications},
  doi = {10.1038/s41467-025-61691-4},
  url = {https://doi.org/10.1038/s41467-025-61691-4}
}

RIS

TY  - JOUR
TI  - Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial
AU  - Dean A. Fennell
AU  - Kayleigh Hill
AU  - Min Zhang
AU  - Charlotte Poile
AU  - Sean Ewings
AU  - Essa Y. Baitei
AU  - Joanna Dzialo
AU  - Nada Nusrat
AU  - Jan Rogel
AU  - Daniel Faulkner
AU  - Christian Ottensmeier
AU  - Raffaele Califano
AU  - Gerard G. Hanna
AU  - Sarah Danson
AU  - Nicola Steele
AU  - Mavis Nye
AU  - Lucy Johnson
AU  - Kim Mallard
AU  - Joanne Lord
AU  - Calley Middleton
AU  - Peter Szlosarek
AU  - Sam Chan
AU  - Liz Darlison
AU  - Peter Wells-Jordan
AU  - Cathy Richards
AU  - James Harber
AU  - Aleksandra Bzura
AU  - Jake Spicer
AU  - Catrin Pritchard
AU  - Tamihiro Kamata
AU  - Jens C. Hahne
AU  - Maymun Jama
AU  - Edward J. Hollox
AU  - Jason F. Lester
AU  - Jin-Li Luo
AU  - Zisen Zhou
AU  - Hongji Yang
AU  - Huiyu Zhou
AU  - Astero Klampatsa
AU  - Gareth O. Griffiths
PY  - 2025
JO  - Nature Communications
DO  - 10.1038/s41467-025-61691-4
UR  - https://doi.org/10.1038/s41467-025-61691-4
ER  -

APA

Fennell, D. A., Hill, K., Zhang, M., Poile, C., Ewings, S., Baitei, E. Y., Dzialo, J., Nusrat, N., Rogel, J., Faulkner, D., Ottensmeier, C., Califano, R., Hanna, G. G., Danson, S., Steele, N., Nye, M., Johnson, L., Mallard, K., Lord, J., Middleton, C., Szlosarek, P., Chan, S., Darlison, L., Wells-Jordan, P., Richards, C., Harber, J., Bzura, A., Spicer, J., Pritchard, C., Kamata, T., Hahne, J. C., Jama, M., Hollox, E. J., Lester, J. F., Luo, J., Zhou, Z., Yang, H., Zhou, H., Klampatsa, A., & Griffiths, G. O. (2025). Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial. Nature Communications. https://doi.org/10.1038/s41467-025-61691-4

Source records

crossref · retrieved 2026-09-27T00:41:07.257Z