Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika R. Iyer, Austin T. Hilliard, Jeffrey Haessler, Ran Tao, K. Alaine Broadaway, Yujie Wang, Nikita Pozdeyev, Frederik F. Stæger, Chaojie Yang, Brett Vanderwerff, Amit D. Patki, Lauren Stalbow, Meng Lin, Nicholas Rafaels, Jonathan Shortt, Laura Wiley, Maggie Stanislawski, Jack Pattee, Lea Davis, Peter S. Straub, Megan M. Shuey, Nancy J. Cox, Nanette R. Lee, Marit E. Jørgensen, Peter Bjerregaard, Christina Larsen, Torben Hansen, Ida Moltke, James B. Meigs, Daniel O. Stram, Xianyong Yin, Xiang Zhou, Kyong-Mi Chang, Shoa L. Clarke, Rodrigo Guarischi-Sousa, Joanna Lankester, Philip S. Tsao, Steven Buyske, Mariaelisa Graff, Laura M. Raffield, Quan Sun, Lynne R. Wilkens, Christopher S. Carlson, Charles B. Easton, Simin Liu, JoAnn E. Manson, Loïc L. Marchand, Christopher A. Haiman, Karen L. Mohlke, Penny Gordon-Larsen, Anders Albrechtsen, Michael Boehnke, Stephen S. Rich, Ani Manichaikul, Jerome I. Rotter, Noha A. Yousri, Ryan M. Irvin, Unknown, Heather D. Anderson, Christina L. Aquilante, Kelsey Arbogast, Christopher H. Arehart, Ian M. Brooks, Tonya M. Brunetti, Judith Brutus-Lestin, Elizabeth E. Burke, Emily M. Casteel, Joanne B. Cole, Curtis R. Coughlin, Kristy Crooks, Jacob Crawford, Erin Culver, Michelle N. Edelmann, Matthew J. Fisher, Alan W. Franklin, Teresa C. Frye, Hunter George, Chris Gignoux, Elizabeth K. Gilliland, Casey S. Greene, Brooke Hawkes, Emily Hearst, Audrey E. Hendricks, Randi K. Johnson, Colleen G. Julian, Dave Kao, Iain Konigsberg, Lisa Ku, Elizabeth L. Kudron, Rashawnda Lacy, Ethan M. Lange, Yee Ming Lee, Joe A. Lesny, Jan T. Lowery, Luciana B. Vargas, Betzaida L. Maldonado, Darcy Marceau, James L. Martin, Brianna L. Gates, David Mayer, Nicole L. McDaniel, Andrew Monte, Ethan Moore, Ann Nadrash, Alaa Radwan, Nick Rafaels, Neda Rasouli, Elise L. Shalowitz, Hoda Sherif, Johnathan Shortt, Adrian M. Stewart, Kristen J. Sutton, Carolyn T. Swartz, Anna Tanaka, Matthew R. G. Taylor, Candace Teague, Emily B. Todd, Katy E. Trinkley, Laura K. Wiley, Unknown, Sumitra Muralidhar, Jennifer Moser, Jennifer E. Deen, J. Michael Gaziano, Elizabeth Hauser, Amy Kilbourne, Michael Matheny, Dave Oslin, Deepak Voora, Jessica V. Brewer, Mary T. Brophy, Kelly Cho, Lori Churby, Scott L. DuVall, Saiju Pyarajan, Robert Ringer, Luis E. Selva, Shahpoor Alex Shayan, Brady Stephens, Stacey B. Whitbourne, Adriana Hung, Henry Kranzler, Chris Gignoux, Kari E. North, Ruth J. F. Loos, Themistocles L. Assimes, Ulrike Peters, Charles Kooperberg, Sridharan Raghavan, Heather M. Highland, Burcu F. Darst

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DOI: 10.1038/s41467-025-63546-4
Published: 2025-10-01
Container: Nature Communications
Publisher: Springer Science and Business Media LLC
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Cite this work

BibTeX

@article{allodium:10.1038/s41467-025-63546-4,
title = {Polygenic risk score for type 2 diabetes shows context-dependent effects across populations},
author = {Boya Guo and Yanwei Cai and Daeeun Kim and Roelof A. J. Smit and Zhe Wang and Kruthika R. Iyer and Austin T. Hilliard and Jeffrey Haessler and Ran Tao and K. Alaine Broadaway and Yujie Wang and Nikita Pozdeyev and Frederik F. Stæger and Chaojie Yang and Brett Vanderwerff and Amit D. Patki and Lauren Stalbow and Meng Lin and Nicholas Rafaels and Jonathan Shortt and Laura Wiley and Maggie Stanislawski and Jack Pattee and Lea Davis and Peter S. Straub and Megan M. Shuey and Nancy J. Cox and Nanette R. Lee and Marit E. Jørgensen and Peter Bjerregaard and Christina Larsen and Torben Hansen and Ida Moltke and James B. Meigs and Daniel O. Stram and Xianyong Yin and Xiang Zhou and Kyong-Mi Chang and Shoa L. Clarke and Rodrigo Guarischi-Sousa and Joanna Lankester and Philip S. Tsao and Steven Buyske and Mariaelisa Graff and Laura M. Raffield and Quan Sun and Lynne R. Wilkens and Christopher S. Carlson and Charles B. Easton and Simin Liu and JoAnn E. Manson and Loïc L. Marchand and Christopher A. Haiman and Karen L. Mohlke and Penny Gordon-Larsen and Anders Albrechtsen and Michael Boehnke and Stephen S. Rich and Ani Manichaikul and Jerome I. Rotter and Noha A. Yousri and Ryan M. Irvin and Unknown and Heather D. Anderson and Christina L. Aquilante and Kelsey Arbogast and Christopher H. Arehart and Ian M. Brooks and Tonya M. Brunetti and Judith Brutus-Lestin and Elizabeth E. Burke and Emily M. Casteel and Joanne B. Cole and Curtis R. Coughlin and Kristy Crooks and Jacob Crawford and Erin Culver and Michelle N. Edelmann and Matthew J. Fisher and Alan W. Franklin and Teresa C. Frye and Hunter George and Chris Gignoux and Elizabeth K. Gilliland and Casey S. Greene and Brooke Hawkes and Emily Hearst and Audrey E. Hendricks and Randi K. Johnson and Colleen G. Julian and Dave Kao and Iain Konigsberg and Lisa Ku and Elizabeth L. Kudron and Rashawnda Lacy and Ethan M. Lange and Yee Ming Lee and Joe A. Lesny and Jan T. Lowery and Luciana B. Vargas and Betzaida L. Maldonado and Darcy Marceau and James L. Martin and Brianna L. Gates and David Mayer and Nicole L. McDaniel and Andrew Monte and Ethan Moore and Ann Nadrash and Alaa Radwan and Nick Rafaels and Neda Rasouli and Elise L. Shalowitz and Hoda Sherif and Johnathan Shortt and Adrian M. Stewart and Kristen J. Sutton and Carolyn T. Swartz and Anna Tanaka and Matthew R. G. Taylor and Candace Teague and Emily B. Todd and Katy E. Trinkley and Laura K. Wiley and Unknown and Sumitra Muralidhar and Jennifer Moser and Jennifer E. Deen and J. Michael Gaziano and Elizabeth Hauser and Amy Kilbourne and Michael Matheny and Dave Oslin and Deepak Voora and Jessica V. Brewer and Mary T. Brophy and Kelly Cho and Lori Churby and Scott L. DuVall and Saiju Pyarajan and Robert Ringer and Luis E. Selva and Shahpoor Alex Shayan and Brady Stephens and Stacey B. Whitbourne and Adriana Hung and Henry Kranzler and Chris Gignoux and Kari E. North and Ruth J. F. Loos and Themistocles L. Assimes and Ulrike Peters and Charles Kooperberg and Sridharan Raghavan and Heather M. Highland and Burcu F. Darst},
year = {2025},
journal = {Nature Communications},
doi = {10.1038/s41467-025-63546-4},
url = {https://doi.org/10.1038/s41467-025-63546-4}
}

RIS

TY  - JOUR
TI  - Polygenic risk score for type 2 diabetes shows context-dependent effects across populations
AU  - Boya Guo
AU  - Yanwei Cai
AU  - Daeeun Kim
AU  - Roelof A. J. Smit
AU  - Zhe Wang
AU  - Kruthika R. Iyer
AU  - Austin T. Hilliard
AU  - Jeffrey Haessler
AU  - Ran Tao
AU  - K. Alaine Broadaway
AU  - Yujie Wang
AU  - Nikita Pozdeyev
AU  - Frederik F. Stæger
AU  - Chaojie Yang
AU  - Brett Vanderwerff
AU  - Amit D. Patki
AU  - Lauren Stalbow
AU  - Meng Lin
AU  - Nicholas Rafaels
AU  - Jonathan Shortt
AU  - Laura Wiley
AU  - Maggie Stanislawski
AU  - Jack Pattee
AU  - Lea Davis
AU  - Peter S. Straub
AU  - Megan M. Shuey
AU  - Nancy J. Cox
AU  - Nanette R. Lee
AU  - Marit E. Jørgensen
AU  - Peter Bjerregaard
AU  - Christina Larsen
AU  - Torben Hansen
AU  - Ida Moltke
AU  - James B. Meigs
AU  - Daniel O. Stram
AU  - Xianyong Yin
AU  - Xiang Zhou
AU  - Kyong-Mi Chang
AU  - Shoa L. Clarke
AU  - Rodrigo Guarischi-Sousa
AU  - Joanna Lankester
AU  - Philip S. Tsao
AU  - Steven Buyske
AU  - Mariaelisa Graff
AU  - Laura M. Raffield
AU  - Quan Sun
AU  - Lynne R. Wilkens
AU  - Christopher S. Carlson
AU  - Charles B. Easton
AU  - Simin Liu
AU  - JoAnn E. Manson
AU  - Loïc L. Marchand
AU  - Christopher A. Haiman
AU  - Karen L. Mohlke
AU  - Penny Gordon-Larsen
AU  - Anders Albrechtsen
AU  - Michael Boehnke
AU  - Stephen S. Rich
AU  - Ani Manichaikul
AU  - Jerome I. Rotter
AU  - Noha A. Yousri
AU  - Ryan M. Irvin
AU  - Unknown
AU  - Heather D. Anderson
AU  - Christina L. Aquilante
AU  - Kelsey Arbogast
AU  - Christopher H. Arehart
AU  - Ian M. Brooks
AU  - Tonya M. Brunetti
AU  - Judith Brutus-Lestin
AU  - Elizabeth E. Burke
AU  - Emily M. Casteel
AU  - Joanne B. Cole
AU  - Curtis R. Coughlin
AU  - Kristy Crooks
AU  - Jacob Crawford
AU  - Erin Culver
AU  - Michelle N. Edelmann
AU  - Matthew J. Fisher
AU  - Alan W. Franklin
AU  - Teresa C. Frye
AU  - Hunter George
AU  - Chris Gignoux
AU  - Elizabeth K. Gilliland
AU  - Casey S. Greene
AU  - Brooke Hawkes
AU  - Emily Hearst
AU  - Audrey E. Hendricks
AU  - Randi K. Johnson
AU  - Colleen G. Julian
AU  - Dave Kao
AU  - Iain Konigsberg
AU  - Lisa Ku
AU  - Elizabeth L. Kudron
AU  - Rashawnda Lacy
AU  - Ethan M. Lange
AU  - Yee Ming Lee
AU  - Joe A. Lesny
AU  - Jan T. Lowery
AU  - Luciana B. Vargas
AU  - Betzaida L. Maldonado
AU  - Darcy Marceau
AU  - James L. Martin
AU  - Brianna L. Gates
AU  - David Mayer
AU  - Nicole L. McDaniel
AU  - Andrew Monte
AU  - Ethan Moore
AU  - Ann Nadrash
AU  - Alaa Radwan
AU  - Nick Rafaels
AU  - Neda Rasouli
AU  - Elise L. Shalowitz
AU  - Hoda Sherif
AU  - Johnathan Shortt
AU  - Adrian M. Stewart
AU  - Kristen J. Sutton
AU  - Carolyn T. Swartz
AU  - Anna Tanaka
AU  - Matthew R. G. Taylor
AU  - Candace Teague
AU  - Emily B. Todd
AU  - Katy E. Trinkley
AU  - Laura K. Wiley
AU  - Unknown
AU  - Sumitra Muralidhar
AU  - Jennifer Moser
AU  - Jennifer E. Deen
AU  - J. Michael Gaziano
AU  - Elizabeth Hauser
AU  - Amy Kilbourne
AU  - Michael Matheny
AU  - Dave Oslin
AU  - Deepak Voora
AU  - Jessica V. Brewer
AU  - Mary T. Brophy
AU  - Kelly Cho
AU  - Lori Churby
AU  - Scott L. DuVall
AU  - Saiju Pyarajan
AU  - Robert Ringer
AU  - Luis E. Selva
AU  - Shahpoor Alex Shayan
AU  - Brady Stephens
AU  - Stacey B. Whitbourne
AU  - Adriana Hung
AU  - Henry Kranzler
AU  - Chris Gignoux
AU  - Kari E. North
AU  - Ruth J. F. Loos
AU  - Themistocles L. Assimes
AU  - Ulrike Peters
AU  - Charles Kooperberg
AU  - Sridharan Raghavan
AU  - Heather M. Highland
AU  - Burcu F. Darst
PY  - 2025
JO  - Nature Communications
DO  - 10.1038/s41467-025-63546-4
UR  - https://doi.org/10.1038/s41467-025-63546-4
ER  -

APA

Guo, B., Cai, Y., Kim, D., Smit, R. A. J., Wang, Z., Iyer, K. R., Hilliard, A. T., Haessler, J., Tao, R., Broadaway, K. A., Wang, Y., Pozdeyev, N., Stæger, F. F., Yang, C., Vanderwerff, B., Patki, A. D., Stalbow, L., Lin, M., Rafaels, N., Shortt, J., Wiley, L., Stanislawski, M., Pattee, J., Davis, L., Straub, P. S., Shuey, M. M., Cox, N. J., Lee, N. R., Jørgensen, M. E., Bjerregaard, P., Larsen, C., Hansen, T., Moltke, I., Meigs, J. B., Stram, D. O., Yin, X., Zhou, X., Chang, K., Clarke, S. L., Guarischi-Sousa, R., Lankester, J., Tsao, P. S., Buyske, S., Graff, M., Raffield, L. M., Sun, Q., Wilkens, L. R., Carlson, C. S., Easton, C. B., Liu, S., Manson, J. E., Marchand, L. L., Haiman, C. A., Mohlke, K. L., Gordon-Larsen, P., Albrechtsen, A., Boehnke, M., Rich, S. S., Manichaikul, A., Rotter, J. I., Yousri, N. A., Irvin, R. M., Unknown, Anderson, H. D., Aquilante, C. L., Arbogast, K., Arehart, C. H., Brooks, I. M., Brunetti, T. M., Brutus-Lestin, J., Burke, E. E., Casteel, E. M., Cole, J. B., Coughlin, C. R., Crooks, K., Crawford, J., Culver, E., Edelmann, M. N., Fisher, M. J., Franklin, A. W., Frye, T. C., George, H., Gignoux, C., Gilliland, E. K., Greene, C. S., Hawkes, B., Hearst, E., Hendricks, A. E., Johnson, R. K., Julian, C. G., Kao, D., Konigsberg, I., Ku, L., Kudron, E. L., Lacy, R., Lange, E. M., Lee, Y. M., Lesny, J. A., Lowery, J. T., Vargas, L. B., Maldonado, B. L., Marceau, D., Martin, J. L., Gates, B. L., Mayer, D., McDaniel, N. L., Monte, A., Moore, E., Nadrash, A., Radwan, A., Rafaels, N., Rasouli, N., Shalowitz, E. L., Sherif, H., Shortt, J., Stewart, A. M., Sutton, K. J., Swartz, C. T., Tanaka, A., Taylor, M. R. G., Teague, C., Todd, E. B., Trinkley, K. E., Wiley, L. K., Unknown, Muralidhar, S., Moser, J., Deen, J. E., Gaziano, J. M., Hauser, E., Kilbourne, A., Matheny, M., Oslin, D., Voora, D., Brewer, J. V., Brophy, M. T., Cho, K., Churby, L., DuVall, S. L., Pyarajan, S., Ringer, R., Selva, L. E., Shayan, S. A., Stephens, B., Whitbourne, S. B., Hung, A., Kranzler, H., Gignoux, C., North, K. E., Loos, R. J. F., Assimes, T. L., Peters, U., Kooperberg, C., Raghavan, S., Highland, H. M., & Darst, B. F. (2025). Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. Nature Communications. https://doi.org/10.1038/s41467-025-63546-4

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crossref · retrieved 2026-09-26T03:06:01.388Z