The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity

Tania Valencia, Laura Y. Yen, Cindy Berman, Thomas Vincent, Scott Davis, Francesca Varrone, Jianfeng Huang, Jessica Mastroianni, Morgan Carlson, Tate Owen, Amin Kamel, Denis Drygin, Garth A. Kinberger, Shanti Pal Gangwar, Maria V. Yelshanskaya, John Ridley, Robert Kirby, Jesus Alvarez, Ronak Lakhia, Vishal Patel, Alexander I. Sobolevsky, Edmund C. Lee

Open source

DOI: 10.1038/s41467-025-65799-5
Published: 2025-11-28
Container: Nature Communications
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-025-65799-5,
  title = {The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity},
  author = {Tania Valencia and Laura Y. Yen and Cindy Berman and Thomas Vincent and Scott Davis and Francesca Varrone and Jianfeng Huang and Jessica Mastroianni and Morgan Carlson and Tate Owen and Amin Kamel and Denis Drygin and Garth A. Kinberger and Shanti Pal Gangwar and Maria V. Yelshanskaya and John Ridley and Robert Kirby and Jesus Alvarez and Ronak Lakhia and Vishal Patel and Alexander I. Sobolevsky and Edmund C. Lee},
  year = {2025},
  journal = {Nature Communications},
  doi = {10.1038/s41467-025-65799-5},
  url = {https://doi.org/10.1038/s41467-025-65799-5}
}

RIS

TY  - JOUR
TI  - The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity
AU  - Tania Valencia
AU  - Laura Y. Yen
AU  - Cindy Berman
AU  - Thomas Vincent
AU  - Scott Davis
AU  - Francesca Varrone
AU  - Jianfeng Huang
AU  - Jessica Mastroianni
AU  - Morgan Carlson
AU  - Tate Owen
AU  - Amin Kamel
AU  - Denis Drygin
AU  - Garth A. Kinberger
AU  - Shanti Pal Gangwar
AU  - Maria V. Yelshanskaya
AU  - John Ridley
AU  - Robert Kirby
AU  - Jesus Alvarez
AU  - Ronak Lakhia
AU  - Vishal Patel
AU  - Alexander I. Sobolevsky
AU  - Edmund C. Lee
PY  - 2025
JO  - Nature Communications
DO  - 10.1038/s41467-025-65799-5
UR  - https://doi.org/10.1038/s41467-025-65799-5
ER  -

APA

Valencia, T., Yen, L. Y., Berman, C., Vincent, T., Davis, S., Varrone, F., Huang, J., Mastroianni, J., Carlson, M., Owen, T., Kamel, A., Drygin, D., Kinberger, G. A., Gangwar, S. P., Yelshanskaya, M. V., Ridley, J., Kirby, R., Alvarez, J., Lakhia, R., Patel, V., Sobolevsky, A. I., & Lee, E. C. (2025). The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity. Nature Communications. https://doi.org/10.1038/s41467-025-65799-5

Source records

crossref · retrieved 2026-09-26T03:53:02.301Z