LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC.

Machida T, Gong Y, Tsukioka S, Onodera A, Nakayama A, Hashimoto N, Fuchigami T, Nishimura M, Ogino T, Kurimoto R, Uematsu Y, Suzuki H, Yu H, Chen M, Yokoyama M, Sakuma I, Taki Y, Kono T, Miki T, Motohashi S, Kawashima Y, Ohara O, Yamashita S, Suzuki T, Hatanaka R, Kodama Y, Ohkubo S, Tanaka T

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DOI: 10.1038/s41467-026-70984-1
Published: 2026 Mar 25
Container: Nature communications
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-026-70984-1,
  title = {LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC.},
  author = {Machida T and Gong Y and Tsukioka S and Onodera A and Nakayama A and Hashimoto N and Fuchigami T and Nishimura M and Ogino T and Kurimoto R and Uematsu Y and Suzuki H and Yu H and Chen M and Yokoyama M and Sakuma I and Taki Y and Kono T and Miki T and Motohashi S and Kawashima Y and Ohara O and Yamashita S and Suzuki T and Hatanaka R and Kodama Y and Ohkubo S and Tanaka T},
  year = {2026},
  journal = {Nature communications},
  doi = {10.1038/s41467-026-70984-1},
  url = {https://doi.org/10.1038/s41467-026-70984-1}
}

RIS

TY  - JOUR
TI  - LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC.
AU  - Machida T
AU  - Gong Y
AU  - Tsukioka S
AU  - Onodera A
AU  - Nakayama A
AU  - Hashimoto N
AU  - Fuchigami T
AU  - Nishimura M
AU  - Ogino T
AU  - Kurimoto R
AU  - Uematsu Y
AU  - Suzuki H
AU  - Yu H
AU  - Chen M
AU  - Yokoyama M
AU  - Sakuma I
AU  - Taki Y
AU  - Kono T
AU  - Miki T
AU  - Motohashi S
AU  - Kawashima Y
AU  - Ohara O
AU  - Yamashita S
AU  - Suzuki T
AU  - Hatanaka R
AU  - Kodama Y
AU  - Ohkubo S
AU  - Tanaka T
PY  - 2026
JO  - Nature communications
DO  - 10.1038/s41467-026-70984-1
UR  - https://doi.org/10.1038/s41467-026-70984-1
ER  -

APA

T, M., Y, G., S, T., A, O., A, N., N, H., T, F., M, N., T, O., R, K., Y, U., H, S., H, Y., M, C., M, Y., I, S., Y, T., T, K., T, M., S, M., Y, K., O, O., S, Y., T, S., R, H., Y, K., S, O., & T, T. (2026). LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC.. Nature communications. https://doi.org/10.1038/s41467-026-70984-1

Source records

pubmed · retrieved 2026-09-26T23:02:01.279Z
europe-pmc · retrieved 2026-09-26T23:02:01.287Z
doaj · retrieved 2026-09-26T23:02:01.285Z