Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids

Carmen Menacho, Satoshi Okawa, Iris Álvarez-Merz, Annika Wittich, Mikel Muñoz-Oreja, Pawel Lisowski, Mario López Martín, Tancredi Massimo Pentimalli, Shiri Zakin, Mathuravani Thevandavakkam, Caleb Jerred, Selene Lickfett, Laura Petersilie, Agnieszka Rybak-Wolf, Annette Seibt, Diran Herebian, Gizem Inak, Susanne Brodesser, Andrea Zaliani, Barbara Mlody, Justin Donnelly, Kasey Woleben, Francesc Xavier Soriano, Jose C. Fernandez-Checa, Natascia Ventura, Sidney Cambridge, Ertan Mayatepek, Antonella Spinazzola, Markus Schuelke, Nikolaus Rajewsky, Andrea Rossi, Alex Peralvarez-Marin, Felix Distelmaier, Ethan Perlstein, Ian J. Holt, Emma Puighermanal, Ole Pless, Christine R. Rose, Antonio Del Sol, Alessandro Prigione

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DOI: 10.1038/s41467-026-71391-2
Published: 2026-04-20
Container: Nature Communications
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-026-71391-2,
  title = {Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids},
  author = {Carmen Menacho and Satoshi Okawa and Iris Álvarez-Merz and Annika Wittich and Mikel Muñoz-Oreja and Pawel Lisowski and Mario López Martín and Tancredi Massimo Pentimalli and Shiri Zakin and Mathuravani Thevandavakkam and Caleb Jerred and Selene Lickfett and Laura Petersilie and Agnieszka Rybak-Wolf and Annette Seibt and Diran Herebian and Gizem Inak and Susanne Brodesser and Andrea Zaliani and Barbara Mlody and Justin Donnelly and Kasey Woleben and Francesc Xavier Soriano and Jose C. Fernandez-Checa and Natascia Ventura and Sidney Cambridge and Ertan Mayatepek and Antonella Spinazzola and Markus Schuelke and Nikolaus Rajewsky and Andrea Rossi and Alex Peralvarez-Marin and Felix Distelmaier and Ethan Perlstein and Ian J. Holt and Emma Puighermanal and Ole Pless and Christine R. Rose and Antonio Del Sol and Alessandro Prigione},
  year = {2026},
  journal = {Nature Communications},
  doi = {10.1038/s41467-026-71391-2},
  url = {https://doi.org/10.1038/s41467-026-71391-2}
}

RIS

TY  - JOUR
TI  - Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids
AU  - Carmen Menacho
AU  - Satoshi Okawa
AU  - Iris Álvarez-Merz
AU  - Annika Wittich
AU  - Mikel Muñoz-Oreja
AU  - Pawel Lisowski
AU  - Mario López Martín
AU  - Tancredi Massimo Pentimalli
AU  - Shiri Zakin
AU  - Mathuravani Thevandavakkam
AU  - Caleb Jerred
AU  - Selene Lickfett
AU  - Laura Petersilie
AU  - Agnieszka Rybak-Wolf
AU  - Annette Seibt
AU  - Diran Herebian
AU  - Gizem Inak
AU  - Susanne Brodesser
AU  - Andrea Zaliani
AU  - Barbara Mlody
AU  - Justin Donnelly
AU  - Kasey Woleben
AU  - Francesc Xavier Soriano
AU  - Jose C. Fernandez-Checa
AU  - Natascia Ventura
AU  - Sidney Cambridge
AU  - Ertan Mayatepek
AU  - Antonella Spinazzola
AU  - Markus Schuelke
AU  - Nikolaus Rajewsky
AU  - Andrea Rossi
AU  - Alex Peralvarez-Marin
AU  - Felix Distelmaier
AU  - Ethan Perlstein
AU  - Ian J. Holt
AU  - Emma Puighermanal
AU  - Ole Pless
AU  - Christine R. Rose
AU  - Antonio Del Sol
AU  - Alessandro Prigione
PY  - 2026
JO  - Nature Communications
DO  - 10.1038/s41467-026-71391-2
UR  - https://doi.org/10.1038/s41467-026-71391-2
ER  -

APA

Menacho, C., Okawa, S., Álvarez-Merz, I., Wittich, A., Muñoz-Oreja, M., Lisowski, P., Martín, M. L., Pentimalli, T. M., Zakin, S., Thevandavakkam, M., Jerred, C., Lickfett, S., Petersilie, L., Rybak-Wolf, A., Seibt, A., Herebian, D., Inak, G., Brodesser, S., Zaliani, A., Mlody, B., Donnelly, J., Woleben, K., Soriano, F. X., Fernandez-Checa, J. C., Ventura, N., Cambridge, S., Mayatepek, E., Spinazzola, A., Schuelke, M., Rajewsky, N., Rossi, A., Peralvarez-Marin, A., Distelmaier, F., Perlstein, E., Holt, I. J., Puighermanal, E., Pless, O., Rose, C. R., Sol, A. D., & Prigione, A. (2026). Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids. Nature Communications. https://doi.org/10.1038/s41467-026-71391-2

Source records

crossref · retrieved 2026-09-26T14:36:37.560Z