Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8+ T cell responses and promoting tertiary lymphoid structure formation

Kazutaka Hosoya, Hiroaki Ozasa, Takahiro Tsuji, Masahiro Oi, Yusuke Shima, Keiichiro Suminaga, Kentaro Hashimoto, Hiroshi Yoshida, Tomoko Funazo, Hitomi Ajimizu, Takashi Nomizo, Hironori Yoshida, Hiroyuki Katsuragawa, Kentaro Tsuji, Noritaka Sano, Shigeki Takada, Yohei Mineharu, Shigeto Nishikawa, Toshi Menju, Akihiko Yoshizawa, Yoshiki Arakawa, Hiroaki Wake, Toyohiro Hirai

Open source

DOI: 10.1038/s41467-026-74782-7
Published: 2026-07-07
Container: Nature Communications
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-026-74782-7,
  title = {Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8+ T cell responses and promoting tertiary lymphoid structure formation},
  author = {Kazutaka Hosoya and Hiroaki Ozasa and Takahiro Tsuji and Masahiro Oi and Yusuke Shima and Keiichiro Suminaga and Kentaro Hashimoto and Hiroshi Yoshida and Tomoko Funazo and Hitomi Ajimizu and Takashi Nomizo and Hironori Yoshida and Hiroyuki Katsuragawa and Kentaro Tsuji and Noritaka Sano and Shigeki Takada and Yohei Mineharu and Shigeto Nishikawa and Toshi Menju and Akihiko Yoshizawa and Yoshiki Arakawa and Hiroaki Wake and Toyohiro Hirai},
  year = {2026},
  journal = {Nature Communications},
  doi = {10.1038/s41467-026-74782-7},
  url = {https://doi.org/10.1038/s41467-026-74782-7}
}

RIS

TY  - JOUR
TI  - Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8+ T cell responses and promoting tertiary lymphoid structure formation
AU  - Kazutaka Hosoya
AU  - Hiroaki Ozasa
AU  - Takahiro Tsuji
AU  - Masahiro Oi
AU  - Yusuke Shima
AU  - Keiichiro Suminaga
AU  - Kentaro Hashimoto
AU  - Hiroshi Yoshida
AU  - Tomoko Funazo
AU  - Hitomi Ajimizu
AU  - Takashi Nomizo
AU  - Hironori Yoshida
AU  - Hiroyuki Katsuragawa
AU  - Kentaro Tsuji
AU  - Noritaka Sano
AU  - Shigeki Takada
AU  - Yohei Mineharu
AU  - Shigeto Nishikawa
AU  - Toshi Menju
AU  - Akihiko Yoshizawa
AU  - Yoshiki Arakawa
AU  - Hiroaki Wake
AU  - Toyohiro Hirai
PY  - 2026
JO  - Nature Communications
DO  - 10.1038/s41467-026-74782-7
UR  - https://doi.org/10.1038/s41467-026-74782-7
ER  -

APA

Hosoya, K., Ozasa, H., Tsuji, T., Oi, M., Shima, Y., Suminaga, K., Hashimoto, K., Yoshida, H., Funazo, T., Ajimizu, H., Nomizo, T., Yoshida, H., Katsuragawa, H., Tsuji, K., Sano, N., Takada, S., Mineharu, Y., Nishikawa, S., Menju, T., Yoshizawa, A., Arakawa, Y., Wake, H., & Hirai, T. (2026). Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8+ T cell responses and promoting tertiary lymphoid structure formation. Nature Communications. https://doi.org/10.1038/s41467-026-74782-7

Source records

crossref · retrieved 2026-09-26T10:13:49.549Z