PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.

Chen P, Xiong K, Huang K, Dong Z, Liang J, Gan X, Li T, Zhang M, Jing S, Xu X, Zheng Y, Li Z, Chen W, Zheng D, Zhong Y, Dai G, Li Q, Chu J, Cao M, Sun J, Liu Z, Li J, Chen S, Zhao Y, Juan Q, Li X, Wen Z, Li Y, Pang H, Wang D, Jiang Y

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DOI: 10.1038/s41467-026-75770-7
Published: 2026 Aug 6
Container: Nature communications
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1038/s41467-026-75770-7,
  title = {PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.},
  author = {Chen P and Xiong K and Huang K and Dong Z and Liang J and Gan X and Li T and Zhang M and Jing S and Xu X and Zheng Y and Li Z and Chen W and Zheng D and Zhong Y and Dai G and Li Q and Chu J and Cao M and Sun J and Liu Z and Li J and Chen S and Zhao Y and Juan Q and Li X and Wen Z and Li Y and Pang H and Wang D and Jiang Y},
  year = {2026},
  journal = {Nature communications},
  doi = {10.1038/s41467-026-75770-7},
  url = {https://doi.org/10.1038/s41467-026-75770-7}
}

RIS

TY  - JOUR
TI  - PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.
AU  - Chen P
AU  - Xiong K
AU  - Huang K
AU  - Dong Z
AU  - Liang J
AU  - Gan X
AU  - Li T
AU  - Zhang M
AU  - Jing S
AU  - Xu X
AU  - Zheng Y
AU  - Li Z
AU  - Chen W
AU  - Zheng D
AU  - Zhong Y
AU  - Dai G
AU  - Li Q
AU  - Chu J
AU  - Cao M
AU  - Sun J
AU  - Liu Z
AU  - Li J
AU  - Chen S
AU  - Zhao Y
AU  - Juan Q
AU  - Li X
AU  - Wen Z
AU  - Li Y
AU  - Pang H
AU  - Wang D
AU  - Jiang Y
PY  - 2026
JO  - Nature communications
DO  - 10.1038/s41467-026-75770-7
UR  - https://doi.org/10.1038/s41467-026-75770-7
ER  -

APA

P, C., K, X., K, H., Z, D., J, L., X, G., T, L., M, Z., S, J., X, X., Y, Z., Z, L., W, C., D, Z., Y, Z., G, D., Q, L., J, C., M, C., J, S., Z, L., J, L., S, C., Y, Z., Q, J., X, L., Z, W., Y, L., H, P., D, W., & Y, J. (2026). PPARα activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.. Nature communications. https://doi.org/10.1038/s41467-026-75770-7

Source records

pubmed · retrieved 2026-09-26T15:00:59.712Z