Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST

T. Schulz, M. Beerbaum, A. Scrima, H. Jantzen, A. Teuber, T. Mühlenberg, L. Ebel, F. Garcia-Fossa, A. George, N. Berner, J. Weisner, M. P. Müller, S. Wilhelm, S. Sievers, S. Bauer, D. Rauh

Open source

DOI
10.1038/s41467-026-76340-7
Published
2026-08-06
Container
Nature Communications
Publisher
Springer Science and Business Media LLC
Open access
unknown

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BibTeX

@article{allodium:10.1038/s41467-026-76340-7,
  title = {Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST},
  author = {T. Schulz and M. Beerbaum and A. Scrima and H. Jantzen and A. Teuber and T. Mühlenberg and L. Ebel and F. Garcia-Fossa and A. George and N. Berner and J. Weisner and M. P. Müller and S. Wilhelm and S. Sievers and S. Bauer and D. Rauh},
  year = {2026},
  journal = {Nature Communications},
  doi = {10.1038/s41467-026-76340-7},
  url = {https://doi.org/10.1038/s41467-026-76340-7}
}

RIS

TY  - JOUR
TI  - Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST
AU  - T. Schulz
AU  - M. Beerbaum
AU  - A. Scrima
AU  - H. Jantzen
AU  - A. Teuber
AU  - T. Mühlenberg
AU  - L. Ebel
AU  - F. Garcia-Fossa
AU  - A. George
AU  - N. Berner
AU  - J. Weisner
AU  - M. P. Müller
AU  - S. Wilhelm
AU  - S. Sievers
AU  - S. Bauer
AU  - D. Rauh
PY  - 2026
JO  - Nature Communications
DO  - 10.1038/s41467-026-76340-7
UR  - https://doi.org/10.1038/s41467-026-76340-7
ER  - 

APA

Schulz, T., Beerbaum, M., Scrima, A., Jantzen, H., Teuber, A., Mühlenberg, T., Ebel, L., Garcia-Fossa, F., George, A., Berner, N., Weisner, J., Müller, M. P., Wilhelm, S., Sievers, S., Bauer, S., & Rauh, D. (2026). Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nature Communications. https://doi.org/10.1038/s41467-026-76340-7

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