Sub-stoichiometric degradation is dispensable for potent PROTACs as demonstrated by irreversible covalent BTK degraders.

Cheng R, Lin H, Yu X, Misra S, Mitchell AD, Woyach JA, Qi X, Wang J

Open source

DOI
10.1038/s41467-026-78239-9
Published
2026 Oct 7
Container
Nature communications
Publisher
Not recorded
Open access
yes

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BibTeX

@article{allodium:10.1038/s41467-026-78239-9,
  title = {Sub-stoichiometric degradation is dispensable for potent PROTACs as demonstrated by irreversible covalent BTK degraders.},
  author = {Cheng R and Lin H and Yu X and Misra S and Mitchell AD and Woyach JA and Qi X and Wang J},
  year = {2026},
  journal = {Nature communications},
  doi = {10.1038/s41467-026-78239-9},
  url = {https://doi.org/10.1038/s41467-026-78239-9}
}

RIS

TY  - JOUR
TI  - Sub-stoichiometric degradation is dispensable for potent PROTACs as demonstrated by irreversible covalent BTK degraders.
AU  - Cheng R
AU  - Lin H
AU  - Yu X
AU  - Misra S
AU  - Mitchell AD
AU  - Woyach JA
AU  - Qi X
AU  - Wang J
PY  - 2026
JO  - Nature communications
DO  - 10.1038/s41467-026-78239-9
UR  - https://doi.org/10.1038/s41467-026-78239-9
ER  - 

APA

R, C., H, L., X, Y., S, M., AD, M., JA, W., X, Q., & J, W. (2026). Sub-stoichiometric degradation is dispensable for potent PROTACs as demonstrated by irreversible covalent BTK degraders.. Nature communications. https://doi.org/10.1038/s41467-026-78239-9

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