Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer

Shu Yazaki, Rui Kitadai, Yukihide Momozawa, Teruhiko Yoshida, Takashi Yamanaka, Sho Shiino, Chisako Yamauchi, Kenichi Harano, Motonobu Saito, Yosuke Hirotsu, Hisaki Aiba, Ryuji Hamamoto, Chikako Shimizu, Akihiko Shimomura, Tatsunori Shimoi, Kazuki Sudo, Masayuki Yoshida, Kuniko Sunami, Yuichi Shiraishi, Aya Kuchiba, Megumi Hori, Kota Katanoda, Sadaaki Takata, Ayumi Ogawa, Masahiro Torasawa, Akifumi Mochizuki, Yoko Shimada, Kengo Hiranuma, Erisa Fujii, Makoto Hirata, Yuji Yamashita, Takahiro Kogawa, Takeshi Murata, Saori Fujiwara, Yohei Miyagi, Hiroshi Nakagomi, Kazunoshin Tachibana, Koichi Matsuda, Yoshinori Murakami, Katsushi Tokunaga, Yosuke Kawai, Unknown, Hatsue Ishibashi-Ueda, Tsutomu Tomita, Michio Noguchi, Ayako Takahashi, Yu-ichi Goto, Sumiko Yoshida, Kotaro Hattori, Ryo Matsumura, Aritoshi Iida, Yutaka Maruoka, Hiroyuki Gatanaga, Masaya Sugiyama, Satoshi Suzuki, Kengo Miyo, Yoichi Matsubara, Akihiro Umezawa, Kenichiro Hata, Tadashi Kaname, Kouichi Ozaki, Haruhiko Tokuda, Hiroshi Watanabe, Shumpei Niida, Eisei Noiri, Koji Kitajima, Yosuke Omae, Reiko Miyahara, Hideyuki Shimanuki, Yosuke Kawai, Biobank Japan Project, Masao Omata, Tohru Ohtake, Akihiko Suto, Tatsuya Onishi, Yoichi Naito, Toshinari Yamashita, Kan Yonemori, Takashi Kohno, Kouya Shiraishi

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DOI: 10.1038/s41523-025-00848-2
Published: 2025-11-28
Container: npj Breast Cancer
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41523-025-00848-2,
  title = {Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer},
  author = {Shu Yazaki and Rui Kitadai and Yukihide Momozawa and Teruhiko Yoshida and Takashi Yamanaka and Sho Shiino and Chisako Yamauchi and Kenichi Harano and Motonobu Saito and Yosuke Hirotsu and Hisaki Aiba and Ryuji Hamamoto and Chikako Shimizu and Akihiko Shimomura and Tatsunori Shimoi and Kazuki Sudo and Masayuki Yoshida and Kuniko Sunami and Yuichi Shiraishi and Aya Kuchiba and Megumi Hori and Kota Katanoda and Sadaaki Takata and Ayumi Ogawa and Masahiro Torasawa and Akifumi Mochizuki and Yoko Shimada and Kengo Hiranuma and Erisa Fujii and Makoto Hirata and Yuji Yamashita and Takahiro Kogawa and Takeshi Murata and Saori Fujiwara and Yohei Miyagi and Hiroshi Nakagomi and Kazunoshin Tachibana and Koichi Matsuda and Yoshinori Murakami and Katsushi Tokunaga and Yosuke Kawai and Unknown and Hatsue Ishibashi-Ueda and Tsutomu Tomita and Michio Noguchi and Ayako Takahashi and Yu-ichi Goto and Sumiko Yoshida and Kotaro Hattori and Ryo Matsumura and Aritoshi Iida and Yutaka Maruoka and Hiroyuki Gatanaga and Masaya Sugiyama and Satoshi Suzuki and Kengo Miyo and Yoichi Matsubara and Akihiro Umezawa and Kenichiro Hata and Tadashi Kaname and Kouichi Ozaki and Haruhiko Tokuda and Hiroshi Watanabe and Shumpei Niida and Eisei Noiri and Koji Kitajima and Yosuke Omae and Reiko Miyahara and Hideyuki Shimanuki and Yosuke Kawai and Biobank Japan Project and Masao Omata and Tohru Ohtake and Akihiko Suto and Tatsuya Onishi and Yoichi Naito and Toshinari Yamashita and Kan Yonemori and Takashi Kohno and Kouya Shiraishi},
  year = {2025},
  journal = {npj Breast Cancer},
  doi = {10.1038/s41523-025-00848-2},
  url = {https://doi.org/10.1038/s41523-025-00848-2}
}

RIS

TY  - JOUR
TI  - Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer
AU  - Shu Yazaki
AU  - Rui Kitadai
AU  - Yukihide Momozawa
AU  - Teruhiko Yoshida
AU  - Takashi Yamanaka
AU  - Sho Shiino
AU  - Chisako Yamauchi
AU  - Kenichi Harano
AU  - Motonobu Saito
AU  - Yosuke Hirotsu
AU  - Hisaki Aiba
AU  - Ryuji Hamamoto
AU  - Chikako Shimizu
AU  - Akihiko Shimomura
AU  - Tatsunori Shimoi
AU  - Kazuki Sudo
AU  - Masayuki Yoshida
AU  - Kuniko Sunami
AU  - Yuichi Shiraishi
AU  - Aya Kuchiba
AU  - Megumi Hori
AU  - Kota Katanoda
AU  - Sadaaki Takata
AU  - Ayumi Ogawa
AU  - Masahiro Torasawa
AU  - Akifumi Mochizuki
AU  - Yoko Shimada
AU  - Kengo Hiranuma
AU  - Erisa Fujii
AU  - Makoto Hirata
AU  - Yuji Yamashita
AU  - Takahiro Kogawa
AU  - Takeshi Murata
AU  - Saori Fujiwara
AU  - Yohei Miyagi
AU  - Hiroshi Nakagomi
AU  - Kazunoshin Tachibana
AU  - Koichi Matsuda
AU  - Yoshinori Murakami
AU  - Katsushi Tokunaga
AU  - Yosuke Kawai
AU  - Unknown
AU  - Hatsue Ishibashi-Ueda
AU  - Tsutomu Tomita
AU  - Michio Noguchi
AU  - Ayako Takahashi
AU  - Yu-ichi Goto
AU  - Sumiko Yoshida
AU  - Kotaro Hattori
AU  - Ryo Matsumura
AU  - Aritoshi Iida
AU  - Yutaka Maruoka
AU  - Hiroyuki Gatanaga
AU  - Masaya Sugiyama
AU  - Satoshi Suzuki
AU  - Kengo Miyo
AU  - Yoichi Matsubara
AU  - Akihiro Umezawa
AU  - Kenichiro Hata
AU  - Tadashi Kaname
AU  - Kouichi Ozaki
AU  - Haruhiko Tokuda
AU  - Hiroshi Watanabe
AU  - Shumpei Niida
AU  - Eisei Noiri
AU  - Koji Kitajima
AU  - Yosuke Omae
AU  - Reiko Miyahara
AU  - Hideyuki Shimanuki
AU  - Yosuke Kawai
AU  - Biobank Japan Project
AU  - Masao Omata
AU  - Tohru Ohtake
AU  - Akihiko Suto
AU  - Tatsuya Onishi
AU  - Yoichi Naito
AU  - Toshinari Yamashita
AU  - Kan Yonemori
AU  - Takashi Kohno
AU  - Kouya Shiraishi
PY  - 2025
JO  - npj Breast Cancer
DO  - 10.1038/s41523-025-00848-2
UR  - https://doi.org/10.1038/s41523-025-00848-2
ER  -

APA

Yazaki, S., Kitadai, R., Momozawa, Y., Yoshida, T., Yamanaka, T., Shiino, S., Yamauchi, C., Harano, K., Saito, M., Hirotsu, Y., Aiba, H., Hamamoto, R., Shimizu, C., Shimomura, A., Shimoi, T., Sudo, K., Yoshida, M., Sunami, K., Shiraishi, Y., Kuchiba, A., Hori, M., Katanoda, K., Takata, S., Ogawa, A., Torasawa, M., Mochizuki, A., Shimada, Y., Hiranuma, K., Fujii, E., Hirata, M., Yamashita, Y., Kogawa, T., Murata, T., Fujiwara, S., Miyagi, Y., Nakagomi, H., Tachibana, K., Matsuda, K., Murakami, Y., Tokunaga, K., Kawai, Y., Unknown, Ishibashi-Ueda, H., Tomita, T., Noguchi, M., Takahashi, A., Goto, Y., Yoshida, S., Hattori, K., Matsumura, R., Iida, A., Maruoka, Y., Gatanaga, H., Sugiyama, M., Suzuki, S., Miyo, K., Matsubara, Y., Umezawa, A., Hata, K., Kaname, T., Ozaki, K., Tokuda, H., Watanabe, H., Niida, S., Noiri, E., Kitajima, K., Omae, Y., Miyahara, R., Shimanuki, H., Kawai, Y., Project, B. J., Omata, M., Ohtake, T., Suto, A., Onishi, T., Naito, Y., Yamashita, T., Yonemori, K., Kohno, T., & Shiraishi, K. (2025). Germline variants of the POLH and RAD51 genes are candidate variants associated with risk of hormone receptor-negative young-onset breast cancer. npj Breast Cancer. https://doi.org/10.1038/s41523-025-00848-2

Source records

crossref · retrieved 2026-09-27T16:30:11.113Z