Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset

BibTeX

@article{allodium:10.1038/s41531-026-01265-3,
  title = {Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset},
  author = {Kai Shi Lim and Maria Teresa Periñan and Elaine Guo Yan Chew and Paul Suhwan Lee and Fulya Akçimen and Jia Lun Lim and Mathew J. Koretsky and Manabu Funayama and Hiroyo Yoshino and Nobutaka Hattori and Rauan Kaiyrzhanov and Henry Houlden and Mariam Isayan and Yi Wen Tay and Tzi Shin Toh and Lei-Cheng Lit and Anis Nadhirah Khairul Anuar and Hans Xing Ding and Laurel Screven and Norlinah Mohamed Ibrahim and Chin-Hsien Lin and Han-Joon Kim and Jee-Young Lee and Sun Ju Chung and Jia Nee Foo and Eng-King Tan and Shen-Yang Lim and Ai Huey Tan and Sara Bandres-Ciga and Azlina Ahmad-Annuar and Unknown and Elaine Guo Yan Chew and Anis Nadhirah Khairul Anuar and Mie Rizig and Njideka Okubadejo and Emilia M. Gatto and Marcelo Kauffman and Samson Khachatryan and Zaruhi Tavadyan and Claire E. Shepherd and Julie Hunter and Kishore Kumar and Melina Ellis and Miguel E. Rentería and Sulev Koks and Alexander Zimprich and Carlos Rieder and Vitor Tumas and Sarah Camargos and Edward A. Fon and Ted Fon and Oury Monchi and Benjamin Pizarro Galleguillos and Patricio Olguin and Marcelo Miranda and Maria Leonor Bustamante and Beisha Tang and Huifang Shang and Jifeng Guo and Piu Chan and Wei Luo and Gonzalo Arboleda and Jorge Orozco and Marlene Jimenez del Rio and Alvaro Hernandez and Mohamed Salama and Walaa A. Kamel and Yared Z. Zewde and Alexis Brice and Jean-Christophe Corvol and Ana Westenberger and Christine Klein and Eva-Juliane Vollstedt and Harutyun Madoev and Joanne Trinh and Johanna Junker and Katja Lohmann and Anastasia Illarionova and Brit Mollenhauer and Franziska Hopfner and Günter Höglinger and Lara M. Lange and Manu Sharma and Thomas Gasser and Zih-Hua Fang and Sergio Groppa and Albert Akpalu and Georgia Xiromerisiou and Georgios Hadjigeorgiou and Efthymios Dardiotis and Ioannis Dagklis and Ioannis Tarnanas and Leonidas Stefanis and Maria Stamelou and Alex Medina and Germaine Hiu-Fai Chan and Nelson Yuk-Fai Cheung and Nancy Ip and Phillip Chan and Xiaopu Zhou and Asha Kishore and K. P. Divya and Pramod Pal and Prashanth Lingappa Kukkle and Roopa Rajan and Rupam Borgohain and Mehri Salari and Andrea Quattrone and Enza Maria Valente and Micol Avenali and Lucilla Parnetti and Tommaso Schirinzi and Tomotaka Shiraishi and Altynay Karimova and Gulnaz Kaishibayeva and Cholpon Shambetova and Rejko Krüger and Nor Azian Abdul Murad and Shahrul Azmin and Wael Mohamed and Daniel Martinez-Ramirez and Mayela Rodriguez-Violante and Paula Reayes-Perez and Bayasgalan Tserensodnom and Rajeev Ojha and Tim J. Anderson and Toni L. Pitcher and Oluwadamilola Ojo and Jan O. Aasly and Lasse Pihlstrøm and Manuela Tan and Shoaib Ur-Rehman and Mario Cornejo-Olivas and Maria Leila Doquenia and Raymond Rosales and Angel Vinuela and Elena Iakovenko and Bashayer Al Mubarak and Muhammad Umair and Ferzana Amod and Jonathan Carr and Soraya Bardien and Beomseok Jeon and Yun Joong Kim and Esther Cubo and Ignacio Alvarez and Janet Hoenicka and Katrin Beyer and Pau Pastor and Sarah El-Sadig and Christiane Zweier and Paul Krack and Ruey-Meei Wu and Hsiu-Chuan Wu and Yih-Ru Wu and Pin-Jui Kung and Serena Wu and Rim Amouri and Samia Ben Sassi and A. Nazl Başak and Özgür Öztop Çakmak and Sibel Ertan and Gencer Genc and Alejandro Martínez-Carrasco and Anette Schrag and Anthony Schapira and Eleanor J. Stafford and Huw Morris and John Hardy and Nicholas Wood and Olaitan Okunoye and Rimona Weil and Simona Jasaitye and Vida Obese and Camille Carroll and Claire Bale and Donald Grosset and Kin Y. Mok and Nigel Williams and Patrick A. Lewis and Seth Love and Simon Stott and Alberto Espay and Luca Marsili and Alyssa O’Grady and Bernadette Siddiqi and Bradford Casey and Brian Fiske and Charisse Comart and Justin C. Solle and Kaileigh Murphy and Maggie Kuhl and Naomi Louie and Sohini Chowdhury and Todd Sherer and Andrew K. Sobering and Cabell Jonas and Carlos Cruchaga and Caroline B. Pantazis and Claire Wegel and Deborah Hall and Ejaz Shamim and Jared Williamson and Ekemini Riley and Sonya Dumanis and Geidy E. Serrano and Thomas Beach and Honglei Chen and Ignacio Juan Keller Sarmiento and Niccolò E. Mencacci and Steven Lubbe and Joseph Jankovic and Miguel Inca-Martinez and Joshua Shulman and Karen Nuytemans and Karl Kieburtz and Katerina Markopoulou and Kenneth Marek and Lana M. Chahine and Lauren Ruffrage and Marissa Dean and Lisa Shulman and Roger Albin and Roy Alcalay and Ruth Walker and Tao Xie and Tatiana Foroud and Duan Nguyen and Toan Nguyen and Masharip Atadzhanov},
  year = {2026},
  journal = {npj Parkinson's Disease},
  doi = {10.1038/s41531-026-01265-3},
  url = {https://doi.org/10.1038/s41531-026-01265-3}
}

RIS

TY  - JOUR
TI  - Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset
AU  - Kai Shi Lim
AU  - Maria Teresa Periñan
AU  - Elaine Guo Yan Chew
AU  - Paul Suhwan Lee
AU  - Fulya Akçimen
AU  - Jia Lun Lim
AU  - Mathew J. Koretsky
AU  - Manabu Funayama
AU  - Hiroyo Yoshino
AU  - Nobutaka Hattori
AU  - Rauan Kaiyrzhanov
AU  - Henry Houlden
AU  - Mariam Isayan
AU  - Yi Wen Tay
AU  - Tzi Shin Toh
AU  - Lei-Cheng Lit
AU  - Anis Nadhirah Khairul Anuar
AU  - Hans Xing Ding
AU  - Laurel Screven
AU  - Norlinah Mohamed Ibrahim
AU  - Chin-Hsien Lin
AU  - Han-Joon Kim
AU  - Jee-Young Lee
AU  - Sun Ju Chung
AU  - Jia Nee Foo
AU  - Eng-King Tan
AU  - Shen-Yang Lim
AU  - Ai Huey Tan
AU  - Sara Bandres-Ciga
AU  - Azlina Ahmad-Annuar
AU  - Unknown
AU  - Elaine Guo Yan Chew
AU  - Anis Nadhirah Khairul Anuar
AU  - Mie Rizig
AU  - Njideka Okubadejo
AU  - Emilia M. Gatto
AU  - Marcelo Kauffman
AU  - Samson Khachatryan
AU  - Zaruhi Tavadyan
AU  - Claire E. Shepherd
AU  - Julie Hunter
AU  - Kishore Kumar
AU  - Melina Ellis
AU  - Miguel E. Rentería
AU  - Sulev Koks
AU  - Alexander Zimprich
AU  - Carlos Rieder
AU  - Vitor Tumas
AU  - Sarah Camargos
AU  - Edward A. Fon
AU  - Ted Fon
AU  - Oury Monchi
AU  - Benjamin Pizarro Galleguillos
AU  - Patricio Olguin
AU  - Marcelo Miranda
AU  - Maria Leonor Bustamante
AU  - Beisha Tang
AU  - Huifang Shang
AU  - Jifeng Guo
AU  - Piu Chan
AU  - Wei Luo
AU  - Gonzalo Arboleda
AU  - Jorge Orozco
AU  - Marlene Jimenez del Rio
AU  - Alvaro Hernandez
AU  - Mohamed Salama
AU  - Walaa A. Kamel
AU  - Yared Z. Zewde
AU  - Alexis Brice
AU  - Jean-Christophe Corvol
AU  - Ana Westenberger
AU  - Christine Klein
AU  - Eva-Juliane Vollstedt
AU  - Harutyun Madoev
AU  - Joanne Trinh
AU  - Johanna Junker
AU  - Katja Lohmann
AU  - Anastasia Illarionova
AU  - Brit Mollenhauer
AU  - Franziska Hopfner
AU  - Günter Höglinger
AU  - Lara M. Lange
AU  - Manu Sharma
AU  - Thomas Gasser
AU  - Zih-Hua Fang
AU  - Sergio Groppa
AU  - Albert Akpalu
AU  - Georgia Xiromerisiou
AU  - Georgios Hadjigeorgiou
AU  - Efthymios Dardiotis
AU  - Ioannis Dagklis
AU  - Ioannis Tarnanas
AU  - Leonidas Stefanis
AU  - Maria Stamelou
AU  - Alex Medina
AU  - Germaine Hiu-Fai Chan
AU  - Nelson Yuk-Fai Cheung
AU  - Nancy Ip
AU  - Phillip Chan
AU  - Xiaopu Zhou
AU  - Asha Kishore
AU  - K. P. Divya
AU  - Pramod Pal
AU  - Prashanth Lingappa Kukkle
AU  - Roopa Rajan
AU  - Rupam Borgohain
AU  - Mehri Salari
AU  - Andrea Quattrone
AU  - Enza Maria Valente
AU  - Micol Avenali
AU  - Lucilla Parnetti
AU  - Tommaso Schirinzi
AU  - Tomotaka Shiraishi
AU  - Altynay Karimova
AU  - Gulnaz Kaishibayeva
AU  - Cholpon Shambetova
AU  - Rejko Krüger
AU  - Nor Azian Abdul Murad
AU  - Shahrul Azmin
AU  - Wael Mohamed
AU  - Daniel Martinez-Ramirez
AU  - Mayela Rodriguez-Violante
AU  - Paula Reayes-Perez
AU  - Bayasgalan Tserensodnom
AU  - Rajeev Ojha
AU  - Tim J. Anderson
AU  - Toni L. Pitcher
AU  - Oluwadamilola Ojo
AU  - Jan O. Aasly
AU  - Lasse Pihlstrøm
AU  - Manuela Tan
AU  - Shoaib Ur-Rehman
AU  - Mario Cornejo-Olivas
AU  - Maria Leila Doquenia
AU  - Raymond Rosales
AU  - Angel Vinuela
AU  - Elena Iakovenko
AU  - Bashayer Al Mubarak
AU  - Muhammad Umair
AU  - Ferzana Amod
AU  - Jonathan Carr
AU  - Soraya Bardien
AU  - Beomseok Jeon
AU  - Yun Joong Kim
AU  - Esther Cubo
AU  - Ignacio Alvarez
AU  - Janet Hoenicka
AU  - Katrin Beyer
AU  - Pau Pastor
AU  - Sarah El-Sadig
AU  - Christiane Zweier
AU  - Paul Krack
AU  - Ruey-Meei Wu
AU  - Hsiu-Chuan Wu
AU  - Yih-Ru Wu
AU  - Pin-Jui Kung
AU  - Serena Wu
AU  - Rim Amouri
AU  - Samia Ben Sassi
AU  - A. Nazl Başak
AU  - Özgür Öztop Çakmak
AU  - Sibel Ertan
AU  - Gencer Genc
AU  - Alejandro Martínez-Carrasco
AU  - Anette Schrag
AU  - Anthony Schapira
AU  - Eleanor J. Stafford
AU  - Huw Morris
AU  - John Hardy
AU  - Nicholas Wood
AU  - Olaitan Okunoye
AU  - Rimona Weil
AU  - Simona Jasaitye
AU  - Vida Obese
AU  - Camille Carroll
AU  - Claire Bale
AU  - Donald Grosset
AU  - Kin Y. Mok
AU  - Nigel Williams
AU  - Patrick A. Lewis
AU  - Seth Love
AU  - Simon Stott
AU  - Alberto Espay
AU  - Luca Marsili
AU  - Alyssa O’Grady
AU  - Bernadette Siddiqi
AU  - Bradford Casey
AU  - Brian Fiske
AU  - Charisse Comart
AU  - Justin C. Solle
AU  - Kaileigh Murphy
AU  - Maggie Kuhl
AU  - Naomi Louie
AU  - Sohini Chowdhury
AU  - Todd Sherer
AU  - Andrew K. Sobering
AU  - Cabell Jonas
AU  - Carlos Cruchaga
AU  - Caroline B. Pantazis
AU  - Claire Wegel
AU  - Deborah Hall
AU  - Ejaz Shamim
AU  - Jared Williamson
AU  - Ekemini Riley
AU  - Sonya Dumanis
AU  - Geidy E. Serrano
AU  - Thomas Beach
AU  - Honglei Chen
AU  - Ignacio Juan Keller Sarmiento
AU  - Niccolò E. Mencacci
AU  - Steven Lubbe
AU  - Joseph Jankovic
AU  - Miguel Inca-Martinez
AU  - Joshua Shulman
AU  - Karen Nuytemans
AU  - Karl Kieburtz
AU  - Katerina Markopoulou
AU  - Kenneth Marek
AU  - Lana M. Chahine
AU  - Lauren Ruffrage
AU  - Marissa Dean
AU  - Lisa Shulman
AU  - Roger Albin
AU  - Roy Alcalay
AU  - Ruth Walker
AU  - Tao Xie
AU  - Tatiana Foroud
AU  - Duan Nguyen
AU  - Toan Nguyen
AU  - Masharip Atadzhanov
PY  - 2026
JO  - npj Parkinson's Disease
DO  - 10.1038/s41531-026-01265-3
UR  - https://doi.org/10.1038/s41531-026-01265-3
ER  - 

APA

Lim, K. S., Periñan, M. T., Chew, E. G. Y., Lee, P. S., Akçimen, F., Lim, J. L., Koretsky, M. J., Funayama, M., Yoshino, H., Hattori, N., Kaiyrzhanov, R., Houlden, H., Isayan, M., Tay, Y. W., Toh, T. S., Lit, L., Anuar, A. N. K., Ding, H. X., Screven, L., Ibrahim, N. M., Lin, C., Kim, H., Lee, J., Chung, S. J., Foo, J. N., Tan, E., Lim, S., Tan, A. H., Bandres-Ciga, S., Ahmad-Annuar, A., Unknown, Chew, E. G. Y., Anuar, A. N. K., Rizig, M., Okubadejo, N., Gatto, E. M., Kauffman, M., Khachatryan, S., Tavadyan, Z., Shepherd, C. E., Hunter, J., Kumar, K., Ellis, M., Rentería, M. E., Koks, S., Zimprich, A., Rieder, C., Tumas, V., Camargos, S., Fon, E. A., Fon, T., Monchi, O., Galleguillos, B. P., Olguin, P., Miranda, M., Bustamante, M. L., Tang, B., Shang, H., Guo, J., Chan, P., Luo, W., Arboleda, G., Orozco, J., Rio, M. J. D., Hernandez, A., Salama, M., Kamel, W. A., Zewde, Y. Z., Brice, A., Corvol, J., Westenberger, A., Klein, C., Vollstedt, E., Madoev, H., Trinh, J., Junker, J., Lohmann, K., Illarionova, A., Mollenhauer, B., Hopfner, F., Höglinger, G., Lange, L. M., Sharma, M., Gasser, T., Fang, Z., Groppa, S., Akpalu, A., Xiromerisiou, G., Hadjigeorgiou, G., Dardiotis, E., Dagklis, I., Tarnanas, I., Stefanis, L., Stamelou, M., Medina, A., Chan, G. H., Cheung, N. Y., Ip, N., Chan, P., Zhou, X., Kishore, A., Divya, K. P., Pal, P., Kukkle, P. L., Rajan, R., Borgohain, R., Salari, M., Quattrone, A., Valente, E. M., Avenali, M., Parnetti, L., Schirinzi, T., Shiraishi, T., Karimova, A., Kaishibayeva, G., Shambetova, C., Krüger, R., Murad, N. A. A., Azmin, S., Mohamed, W., Martinez-Ramirez, D., Rodriguez-Violante, M., Reayes-Perez, P., Tserensodnom, B., Ojha, R., Anderson, T. J., Pitcher, T. L., Ojo, O., Aasly, J. O., Pihlstrøm, L., Tan, M., Ur-Rehman, S., Cornejo-Olivas, M., Doquenia, M. L., Rosales, R., Vinuela, A., Iakovenko, E., Mubarak, B. A., Umair, M., Amod, F., Carr, J., Bardien, S., Jeon, B., Kim, Y. J., Cubo, E., Alvarez, I., Hoenicka, J., Beyer, K., Pastor, P., El-Sadig, S., Zweier, C., Krack, P., Wu, R., Wu, H., Wu, Y., Kung, P., Wu, S., Amouri, R., Sassi, S. B., Başak, A. N., Çakmak, Ö. Ö., Ertan, S., Genc, G., Martínez-Carrasco, A., Schrag, A., Schapira, A., Stafford, E. J., Morris, H., Hardy, J., Wood, N., Okunoye, O., Weil, R., Jasaitye, S., Obese, V., Carroll, C., Bale, C., Grosset, D., Mok, K. Y., Williams, N., Lewis, P. A., Love, S., Stott, S., Espay, A., Marsili, L., O’Grady, A., Siddiqi, B., Casey, B., Fiske, B., Comart, C., Solle, J. C., Murphy, K., Kuhl, M., Louie, N., Chowdhury, S., Sherer, T., Sobering, A. K., Jonas, C., Cruchaga, C., Pantazis, C. B., Wegel, C., Hall, D., Shamim, E., Williamson, J., Riley, E., Dumanis, S., Serrano, G. E., Beach, T., Chen, H., Sarmiento, I. J. K., Mencacci, N. E., Lubbe, S., Jankovic, J., Inca-Martinez, M., Shulman, J., Nuytemans, K., Kieburtz, K., Markopoulou, K., Marek, K., Chahine, L. M., Ruffrage, L., Dean, M., Shulman, L., Albin, R., Alcalay, R., Walker, R., Xie, T., Foroud, T., Nguyen, D., Nguyen, T., & Atadzhanov, M. (2026). Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset. npj Parkinson's Disease. https://doi.org/10.1038/s41531-026-01265-3