Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function.
- DOI
- 10.1038/s41531-026-01382-z
- Published
- 2026 May 12
- Container
- NPJ Parkinson's disease
- Publisher
- Not recorded
- Open access
- yes
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Cite this work
BibTeX
@article{allodium:10.1038/s41531-026-01382-z,
title = {Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function.},
author = {Zuo X and Chen Z and Chen XQ and Guan D and Shaw PX and Johnstone A and Becker A and Das U and Mobley WC},
year = {2026},
journal = {NPJ Parkinson's disease},
doi = {10.1038/s41531-026-01382-z},
url = {https://doi.org/10.1038/s41531-026-01382-z}
}RIS
TY - JOUR TI - Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function. AU - Zuo X AU - Chen Z AU - Chen XQ AU - Guan D AU - Shaw PX AU - Johnstone A AU - Becker A AU - Das U AU - Mobley WC PY - 2026 JO - NPJ Parkinson's disease DO - 10.1038/s41531-026-01382-z UR - https://doi.org/10.1038/s41531-026-01382-z ER -
APA
X, Z., Z, C., XQ, C., D, G., PX, S., A, J., A, B., U, D., & WC, M. (2026). Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic function.. NPJ Parkinson's disease. https://doi.org/10.1038/s41531-026-01382-z
Source records
- pubmed · retrieved 2026-09-27T00:47:15.254Z