Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies

Joachim Rudolph, Klaus P. Hoeflich, Arvin C. Dar

Open source

DOI: 10.1038/s41573-026-01411-9
Published: 2026-04-28
Container: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41573-026-01411-9,
  title = {Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies},
  author = {Joachim Rudolph and Klaus P. Hoeflich and Arvin C. Dar},
  year = {2026},
  journal = {Nature Reviews Drug Discovery},
  doi = {10.1038/s41573-026-01411-9},
  url = {https://doi.org/10.1038/s41573-026-01411-9}
}

RIS

TY  - JOUR
TI  - Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies
AU  - Joachim Rudolph
AU  - Klaus P. Hoeflich
AU  - Arvin C. Dar
PY  - 2026
JO  - Nature Reviews Drug Discovery
DO  - 10.1038/s41573-026-01411-9
UR  - https://doi.org/10.1038/s41573-026-01411-9
ER  -

APA

Rudolph, J., Hoeflich, K. P., & Dar, A. C. (2026). Contemporary design of small-molecule kinase modulators: orthosteric, allosteric and induced-proximity strategies. Nature Reviews Drug Discovery. https://doi.org/10.1038/s41573-026-01411-9

Source records

crossref · retrieved 2026-09-26T16:45:38.446Z