CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.

Skoulidis F, Araujo HA, Do MT, Qian Y, Sun X, Galan-Cobo A, Le JT, Montesion M, Palmer R, Jahchan N, Juan JM, Min C, Yu Y, Pan X, Arbour KC, Vokes N, Schmidt ST, Molkentine D, Owen DH, Memmott R, Patil PD, Marmarelis ME, Awad MM, Murray JC, Hellyer JA, Gainor JF, Dimou A, Bestvina CM, Shu CA, Riess JW, Blakely CM, Pecot CV, Mezquita L, Tabbó F, Scheffler M, Digumarthy S, Mooradian MJ, Sacher AG, Lau SCM, Saltos AN, Rotow J, Johnson RP, Liu C, Stewart T, Goldberg SB, Killam J, Walther Z, Schalper K, Davies KD, Woodcock MG, Anagnostou V, Marrone KA, Forde PM, Ricciuti B, Venkatraman D, Van Allen EM, Cummings AL, Goldman JW, Shaish H, Kier M, Katz S, Aggarwal C, Ni Y, Azok JT, Segal J, Ritterhouse L, Neal JW, Lacroix L, Elamin YY, Negrao MV, Le X, Lam VK, Lewis WE, Kemp HN, Carter B, Roth JA, Swisher S, Lee R, Zhou T, Poteete A, Kong Y, Takehara T, Paula AG, Parra Cuentas ER, Behrens C, Wistuba II, Zhang J, Blumenschein GR, Gay C, Byers LA, Gibbons DL, Tsao A, Lee JJ, Bivona TG, Camidge DR, Gray JE, Leighl NB, Levy B, Brahmer JR, Garassino MC, Gandara DR, Garon EB, Rizvi NA, Scagliotti GV, Wolf J, Planchard D, Besse B, Herbst RS, Wakelee HA, Pennell NA, Shaw AT, Jänne PA, Carbone DP, Hellmann MD, Rudin CM, Albacker L, Mann H, Zhu Z, Lai Z, Stewart R, Peters S, Johnson ML, Wong KK, Huang A, Winslow MM, Rosen MJ, Winters IP, Papadimitrakopoulou VA, Cascone T, Jewsbury P, Heymach JV

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DOI: 10.1038/s41586-024-07943-7
Published: 2024 Nov
Container: Nature
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1038/s41586-024-07943-7,
  title = {CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.},
  author = {Skoulidis F and Araujo HA and Do MT and Qian Y and Sun X and Galan-Cobo A and Le JT and Montesion M and Palmer R and Jahchan N and Juan JM and Min C and Yu Y and Pan X and Arbour KC and Vokes N and Schmidt ST and Molkentine D and Owen DH and Memmott R and Patil PD and Marmarelis ME and Awad MM and Murray JC and Hellyer JA and Gainor JF and Dimou A and Bestvina CM and Shu CA and Riess JW and Blakely CM and Pecot CV and Mezquita L and Tabbó F and Scheffler M and Digumarthy S and Mooradian MJ and Sacher AG and Lau SCM and Saltos AN and Rotow J and Johnson RP and Liu C and Stewart T and Goldberg SB and Killam J and Walther Z and Schalper K and Davies KD and Woodcock MG and Anagnostou V and Marrone KA and Forde PM and Ricciuti B and Venkatraman D and Van Allen EM and Cummings AL and Goldman JW and Shaish H and Kier M and Katz S and Aggarwal C and Ni Y and Azok JT and Segal J and Ritterhouse L and Neal JW and Lacroix L and Elamin YY and Negrao MV and Le X and Lam VK and Lewis WE and Kemp HN and Carter B and Roth JA and Swisher S and Lee R and Zhou T and Poteete A and Kong Y and Takehara T and Paula AG and Parra Cuentas ER and Behrens C and Wistuba II and Zhang J and Blumenschein GR and Gay C and Byers LA and Gibbons DL and Tsao A and Lee JJ and Bivona TG and Camidge DR and Gray JE and Leighl NB and Levy B and Brahmer JR and Garassino MC and Gandara DR and Garon EB and Rizvi NA and Scagliotti GV and Wolf J and Planchard D and Besse B and Herbst RS and Wakelee HA and Pennell NA and Shaw AT and Jänne PA and Carbone DP and Hellmann MD and Rudin CM and Albacker L and Mann H and Zhu Z and Lai Z and Stewart R and Peters S and Johnson ML and Wong KK and Huang A and Winslow MM and Rosen MJ and Winters IP and Papadimitrakopoulou VA and Cascone T and Jewsbury P and Heymach JV},
  year = {2024},
  journal = {Nature},
  doi = {10.1038/s41586-024-07943-7},
  url = {https://doi.org/10.1038/s41586-024-07943-7}
}

RIS

TY  - JOUR
TI  - CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
AU  - Skoulidis F
AU  - Araujo HA
AU  - Do MT
AU  - Qian Y
AU  - Sun X
AU  - Galan-Cobo A
AU  - Le JT
AU  - Montesion M
AU  - Palmer R
AU  - Jahchan N
AU  - Juan JM
AU  - Min C
AU  - Yu Y
AU  - Pan X
AU  - Arbour KC
AU  - Vokes N
AU  - Schmidt ST
AU  - Molkentine D
AU  - Owen DH
AU  - Memmott R
AU  - Patil PD
AU  - Marmarelis ME
AU  - Awad MM
AU  - Murray JC
AU  - Hellyer JA
AU  - Gainor JF
AU  - Dimou A
AU  - Bestvina CM
AU  - Shu CA
AU  - Riess JW
AU  - Blakely CM
AU  - Pecot CV
AU  - Mezquita L
AU  - Tabbó F
AU  - Scheffler M
AU  - Digumarthy S
AU  - Mooradian MJ
AU  - Sacher AG
AU  - Lau SCM
AU  - Saltos AN
AU  - Rotow J
AU  - Johnson RP
AU  - Liu C
AU  - Stewart T
AU  - Goldberg SB
AU  - Killam J
AU  - Walther Z
AU  - Schalper K
AU  - Davies KD
AU  - Woodcock MG
AU  - Anagnostou V
AU  - Marrone KA
AU  - Forde PM
AU  - Ricciuti B
AU  - Venkatraman D
AU  - Van Allen EM
AU  - Cummings AL
AU  - Goldman JW
AU  - Shaish H
AU  - Kier M
AU  - Katz S
AU  - Aggarwal C
AU  - Ni Y
AU  - Azok JT
AU  - Segal J
AU  - Ritterhouse L
AU  - Neal JW
AU  - Lacroix L
AU  - Elamin YY
AU  - Negrao MV
AU  - Le X
AU  - Lam VK
AU  - Lewis WE
AU  - Kemp HN
AU  - Carter B
AU  - Roth JA
AU  - Swisher S
AU  - Lee R
AU  - Zhou T
AU  - Poteete A
AU  - Kong Y
AU  - Takehara T
AU  - Paula AG
AU  - Parra Cuentas ER
AU  - Behrens C
AU  - Wistuba II
AU  - Zhang J
AU  - Blumenschein GR
AU  - Gay C
AU  - Byers LA
AU  - Gibbons DL
AU  - Tsao A
AU  - Lee JJ
AU  - Bivona TG
AU  - Camidge DR
AU  - Gray JE
AU  - Leighl NB
AU  - Levy B
AU  - Brahmer JR
AU  - Garassino MC
AU  - Gandara DR
AU  - Garon EB
AU  - Rizvi NA
AU  - Scagliotti GV
AU  - Wolf J
AU  - Planchard D
AU  - Besse B
AU  - Herbst RS
AU  - Wakelee HA
AU  - Pennell NA
AU  - Shaw AT
AU  - Jänne PA
AU  - Carbone DP
AU  - Hellmann MD
AU  - Rudin CM
AU  - Albacker L
AU  - Mann H
AU  - Zhu Z
AU  - Lai Z
AU  - Stewart R
AU  - Peters S
AU  - Johnson ML
AU  - Wong KK
AU  - Huang A
AU  - Winslow MM
AU  - Rosen MJ
AU  - Winters IP
AU  - Papadimitrakopoulou VA
AU  - Cascone T
AU  - Jewsbury P
AU  - Heymach JV
PY  - 2024
JO  - Nature
DO  - 10.1038/s41586-024-07943-7
UR  - https://doi.org/10.1038/s41586-024-07943-7
ER  -

APA

F, S., HA, A., MT, D., Y, Q., X, S., A, G., JT, L., M, M., R, P., N, J., JM, J., C, M., Y, Y., X, P., KC, A., N, V., ST, S., D, M., DH, O., R, M., PD, P., ME, M., MM, A., JC, M., JA, H., JF, G., A, D., CM, B., CA, S., JW, R., CM, B., CV, P., L, M., F, T., M, S., S, D., MJ, M., AG, S., SCM, L., AN, S., J, R., RP, J., C, L., T, S., SB, G., J, K., Z, W., K, S., KD, D., MG, W., V, A., KA, M., PM, F., B, R., D, V., EM, V. A., AL, C., JW, G., H, S., M, K., S, K., C, A., Y, N., JT, A., J, S., L, R., JW, N., L, L., YY, E., MV, N., X, L., VK, L., WE, L., HN, K., B, C., JA, R., S, S., R, L., T, Z., A, P., Y, K., T, T., AG, P., ER, P. C., C, B., II, W., J, Z., GR, B., C, G., LA, B., DL, G., A, T., JJ, L., TG, B., DR, C., JE, G., NB, L., B, L., JR, B., MC, G., DR, G., EB, G., NA, R., GV, S., J, W., D, P., B, B., RS, H., HA, W., NA, P., AT, S., PA, J., DP, C., MD, H., CM, R., L, A., H, M., Z, Z., Z, L., R, S., S, P., ML, J., KK, W., A, H., MM, W., MJ, R., IP, W., VA, P., T, C., P, J., & JV, H. (2024). CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.. Nature. https://doi.org/10.1038/s41586-024-07943-7

Source records

pubmed · retrieved 2026-09-26T07:52:37.372Z